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Literature DB >> 24183971

Targeting mitochondrial DNA with a platinum-based anticancer agent.

Simon P Wisnovsky¹, Justin J Wilson, Robert J Radford, Mark P Pereira, Maria R Chan, Rebecca R Laposa, Stephen J Lippard, Shana O Kelley.

Abstract

An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.

Entities: CellLine Chemical Disease Gene Species

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Year: 2013 PMID： 24183971 PMCID： PMC4082333 DOI： 10.1016/j.chembiol.2013.08.010

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

26 in total

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Authors: Kristin L Horton; Kelly M Stewart; Sonali B Fonseca; Qian Guo; Shana O Kelley
Journal: Chem Biol Date: 2008-04

3. NIH Image to ImageJ: 25 years of image analysis.

Authors: Caroline A Schneider; Wayne S Rasband; Kevin W Eliceiri
Journal: Nat Methods Date: 2012-07 Impact factor: 28.547

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Authors: Nora Graf; Tara E Mokhtari; Ioannis A Papayannopoulos; Stephen J Lippard
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Authors: S Isonishi; M Saitou; M Yasuda; T Tanaka
Journal: Hum Cell Date: 2001-09 Impact factor: 4.174

6. Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin.

Authors: Michael Groessl; Olivier Zava; Paul J Dyson
Journal: Metallomics Date: 2011-03-11 Impact factor: 4.526

7. Peptide targeting of platinum anti-cancer drugs.

Authors: Margaret W Ndinguri; Rajasree Solipuram; Robert P Gambrell; Sita Aggarwal; Robert P Hammer
Journal: Bioconjug Chem Date: 2009-09-23 Impact factor: 4.774

8. Colocalization of fluorescent markers in confocal microscope images of plant cells.

Authors: Andrew P French; Steven Mills; Ranjan Swarup; Malcolm J Bennett; Tony P Pridmore
Journal: Nat Protoc Date: 2008 Impact factor: 13.491

9. Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature.

Authors: Sumitra Mukhopadhyay; Carmen M Barnés; Ariel Haskel; Sarah M Short; Katie R Barnes; Stephen J Lippard
Journal: Bioconjug Chem Date: 2007-09-11 Impact factor: 4.774

Review 10. Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer.

Authors: Kevin J Cullen; Zejia Yang; Lisa Schumaker; Zhongmin Guo
Journal: J Bioenerg Biomembr Date: 2007-02 Impact factor: 3.853

41 in total

Review 1. Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives.

Authors: Gantumur Battogtokh; Yeon Su Choi; Dong Seop Kang; Sang Jun Park; Min Suk Shim; Kang Moo Huh; Yong-Yeon Cho; Joo Young Lee; Hye Suk Lee; Han Chang Kang
Journal: Acta Pharm Sin B Date: 2018-05-18 Impact factor: 11.413

Targeting mitochondrial DNA with a platinum-based anticancer agent.

1. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.

2. Mitochondria-penetrating peptides.

3. NIH Image to ImageJ: 25 years of image analysis.

4. Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells.

5. Mitochondria in platinum resistant cells.

6. Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin.

7. Peptide targeting of platinum anti-cancer drugs.

8. Colocalization of fluorescent markers in confocal microscope images of plant cells.

9. Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature.

Review 10. Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer.

Review 1. Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives.

2. Targeted Chemotherapy with Metal Complexes.

Review 3. Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions.

Review 4. Mitochondrially targeted fluorescent redox sensors.

5. Poisoning of mitochondrial topoisomerase I by lamellarin D.

6. Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes.

Review 7. Targeted nanoparticles in mitochondrial medicine.

Review 8. An integrated view of cisplatin-induced nephrotoxicity and ototoxicity.

Review 9. The Platin-X series: activation, targeting, and delivery.

Review 10. Nanotechnology inspired tools for mitochondrial dysfunction related diseases.