Literature DB >> 24180389

Regulation of eNOS enzyme activity by posttranslational modification.

Elke H Heiss, Verena M Dirsch1.   

Abstract

The regulation of endothelial NO synthase (eNOS) employs multiple different cellular control mechanisms impinging on level and activity of the enzyme. This review aims at summarizing the current knowledge on the posttranslational modifications of eNOS, including acylation, nitrosylation, phosphorylation, acetylation, glycosylation and glutathionylation. Sites, mediators and impact on enzyme localization and activity of the single modifications will be discussed. Moreover, interdependence, cooperativity and competition between the different posttranslational modifications will be elaborated with special emphasis on the susceptibility of eNOS to metabolic cues.

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Year:  2014        PMID： 24180389      PMCID： PMC4401012          DOI： 10.2174/13816128113196660745

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  107 in total

1.  Chk1 and Hsp90 cooperatively regulate phosphorylation of endothelial nitric oxide synthase at serine 1179.

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Journal:  Free Radic Biol Med       Date:  2011-09-25       Impact factor: 7.376

2.  Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization.

Authors:  J Liu; G García-Cardeña; W C Sessa
Journal:  Biochemistry       Date:  1996-10-15       Impact factor: 3.162

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Authors:  D Grahame Hardie; Fiona A Ross; Simon A Hawley
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4.  Differences in eNOS activity because of subcellular localization are dictated by phosphorylation state rather than the local calcium environment.

Authors:  Jarrod E Church; David Fulton
Journal:  J Biol Chem       Date:  2005-10-28       Impact factor: 5.157

5.  A chimeric transmembrane domain directs endothelial nitric-oxide synthase palmitoylation and targeting to plasmalemmal caveolae.

Authors:  P Prabhakar; V Cheng; T Michel
Journal:  J Biol Chem       Date:  2000-06-23       Impact factor: 5.157

6.  Molecular convergence of hexosamine biosynthetic pathway and ER stress leading to insulin resistance in L6 skeletal muscle cells.

Authors:  V Srinivasan; U Tatu; V Mohan; M Balasubramanyam
Journal:  Mol Cell Biochem       Date:  2009-04-16       Impact factor: 3.396

Review 7.  Thiol chemistry and specificity in redox signaling.

Authors:  Christine C Winterbourn; Mark B Hampton
Journal:  Free Radic Biol Med       Date:  2008-05-16       Impact factor: 7.376

8.  Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels.

Authors:  Elke H Heiss; Daniel Schachner; Ernst R Werner; Verena M Dirsch
Journal:  J Biol Chem       Date:  2009-09-21       Impact factor: 5.157

9.  Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase.

Authors:  Yong Chool Boo; George P Sorescu; Philip M Bauer; David Fulton; Bruce E Kemp; David G Harrison; William C Sessa; Hanjoong Jo
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10.  The ancient drug salicylate directly activates AMP-activated protein kinase.

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Journal:  Science       Date:  2012-04-19       Impact factor: 47.728
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  50 in total

Review 1.  NO control of mitochondrial function in normal and transformed cells.

Authors:  Celia H Tengan; Carlos T Moraes
Journal:  Biochim Biophys Acta Bioenerg       Date:  2017-02-16       Impact factor: 3.991

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Authors:  Seong Hoon Park; Sun-Oh Jeong; Hun-Teag Chung; Hyun-Ock Pae
Journal:  Plant Foods Hum Nutr       Date:  2015-09       Impact factor: 3.921

3.  Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.

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4.  Genotype-phenotype effects of Bmpr2 mutations on disease severity in mouse models of pulmonary hypertension.

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Review 5.  Endothelial nitric oxide synthase in the microcirculation.

Authors:  Xiaohong Shu; T C Stevenson Keller; Daniela Begandt; Joshua T Butcher; Lauren Biwer; Alexander S Keller; Linda Columbus; Brant E Isakson
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6.  Endothelial nitric oxide synthase activation is required for heparin receptor effects on vascular smooth muscle cells.

Authors:  Yaqiu Li; Leanna M Talotta-Altenburg; Kayli A Silimperi; Grace O Ciabattoni; Linda J Lowe-Krentz
Journal:  Am J Physiol Cell Physiol       Date:  2019-12-31       Impact factor: 4.249

7.  Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model.

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8.  Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles.

Authors:  Travis W Hein; Xin Xu; Yi Ren; Wenjuan Xu; Shu-Huai Tsai; Naris Thengchaisri; Lih Kuo
Journal:  J Mol Cell Cardiol       Date:  2019-04-20       Impact factor: 5.000

9.  Nitric oxide donor [Ru(terpy)(bdq)NO]3+ induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production.

Authors:  Simone R Potje; Zhenlong Chen; Suellen D'Arc S Oliveira; Lusiane M Bendhack; Roberto S da Silva; Marcelo G Bonini; Cristina Antoniali; Richard D Minshall
Journal:  Free Radic Biol Med       Date:  2017-09-09       Impact factor: 7.376

10.  Pulse pressure-dependent cerebrovascular eNOS regulation in mice.

Authors:  Adeline Raignault; Virginie Bolduc; Frédéric Lesage; Eric Thorin
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