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Literature DB >> 2417916

A refined experimental model for proliferative vitreoretinopathy.

D B Chandler, F A Quansah, T Hida, R Machemer.

Abstract

Animal models of proliferative vitreoretinopathy (PVR) in which the intact vitreous is injected with large numbers of tissue cultured fibroblasts do not accurately represent the disease as it is found in humans. A refined model of PVR is presented, in which the vitreous is compressed and partially detached using intravitreally injected perfluorpropane, followed by injection of 25,000 homologous fibroblasts. Proliferation occurred on the retinal surface, causing retinal detachments with the same frequency as models using greater numbers of cells.

Entities: Chemical Disease Species

Mesh：

Substances：
Fluorocarbons
perflutren

Year: 1986 PMID： 2417916 DOI： 10.1007/bf02144144

Source DB: PubMed Journal: Graefes Arch Clin Exp Ophthalmol ISSN： 0721-832X Impact factor: 3.117

6 in total

1. The role of cellular proliferation in an experimental model of massive periretinal proliferation.

Authors: D M Fastenberg; K R Diddie; K Dorey; S J Ryan
Journal: Am J Ophthalmol Date: 1982-05 Impact factor: 5.258

2. Intravitreal autotransplantation of fibroblasts.

Authors: G Sugita; Y Tano; R Machemer; G Abrams; A Claflin; G Fiorentino
Journal: Am J Ophthalmol Date: 1980-01 Impact factor: 5.258

3. Intravitreal behavior of perfluorocarbons.

Authors: A Lincoff; I Kreissig
Journal: Dev Ophthalmol Date: 1981

4. Experimental Fibroplasia in the rabbit vitreous. Retinal detachment induced by autologous fibroblasts.

Authors: P Algvere; E Kock
Journal: Albrecht Von Graefes Arch Klin Exp Ophthalmol Date: 1976-05-26

5. Temporary use of silicone oil in the treatment of proliferative vitreoretinopathy. An experimental study with a new animal model.

Authors: M Gonvers; R Thresher
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1983 Impact factor: 3.117

6. Gas-mediated vitreous compression: an experimental alternative to mechanized vitrectomy.

Authors: R J Thresher; M Ehrenberg; R Machemer
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1984 Impact factor: 3.117

6 in total

16 in total

1. Evaluation of radiation therapy for experimental proliferative vitreoretinopathy in rabbits.

Authors: S Kuriyama; T Ohuchi; N Yoshimura; Y Honda; M Hiraoka; M Abe
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1990 Impact factor: 3.117

2. The lack of an effect of intraocular steroids on irradiated fibroblasts in experimental proliferative vitreoretinopathy.

Authors: D B Chandler; T Hida; G Rozakis; V S Forbes; R Machemer
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1992 Impact factor: 3.117

3. Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment.

Authors: D B Chandler; T Hida; S Sheta; A D Proia; R Machemer
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1987 Impact factor: 3.117

4. Classification of the stages of proliferative vitreoretinopathy in a refined experimental model in the rabbit eye.

Authors: T Hida; D B Chandler; S M Sheta
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1987 Impact factor: 3.117

5. A model of chronic hypotony in the rabbit.

Authors: H C Kim; A Hayashi; A Shalash; E de Juan
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1998-01 Impact factor: 3.117

6. Measurement of cellular proliferation within the vitreous during experimental proliferative vitreoretinopathy.

Authors: C M Yang; K R Olsen; E Hernandez; S W Cousins
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1992 Impact factor: 3.117

7. Daunorubicin treatment in a refined experimental model of proliferative vitreoretinopathy.

Authors: J A Khawly; P Saloupis; D L Hatchell; R Machemer
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1991 Impact factor: 3.117

8. Growth inhibition of human Tenon's capsule fibroblasts and rabbit dermal fibroblasts with non-carcinogenic N-alkylated anthracyclines.

Authors: U H Steinhorst; E P Chen; S F Freedman; R Machemer; D L Hatchell
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1994-06 Impact factor: 3.117

9. Experimental traction retinal detachment in the cat.

Authors: C A Wilson; J A Khawly; D L Hatchell; R Machemer
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1991 Impact factor: 3.117

10. Ocular toxicity of daunomycin: effects of subdivided doses on the rabbit retina after vitreous gas compression.

Authors: U H Steinhorst; D L Hatchell; E P Chen; R Machemer
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1993-10 Impact factor: 3.117