Literature DB >> 2417908

Effect of somatostatin and its analogs on histamine-stimulated cAMP production in isolated guinea pig gastric glands.

S Nishihara, A Tanaka, K Yoshida, Y Imazono, T Misawa, A Funakoshi, H Ibayashi.   

Abstract

The effect of somatostatin-14 (ss-14), somatostatin-28 (ss-28), and [D-trp8]somatostatin-14 ([ D-trp8]ss-14) on both histamine-stimulated cellular cAMP production and [3H]-cimetidine binding on plasma membranes in isolated guinea pig gastric glands was investigated. These three peptides partially inhibited (approximately 50% maximally) the increase of cAMP production stimulated by histamine. There was no inhibition of [3H]-cimetidine binding on plasma membranes from these isolated gastric glands. These results indicate that somatostatin acts directly on parietal cells and inhibits histamine-stimulated cAMP production with no influence on H2 receptor in histamine stimulated gastric secretion. Inhibitory potency of somatostatin and its analogs against histamine-stimulation may be equal at the cellular level.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2417908     DOI： 10.1007/bf02774813

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  14 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Effect of somatostatin analogs on gastric and pancreatic secretion.

Authors:  S J Konturek; J Tasler; R Krol; A Dembinski; D H Coy; A V Schally
Journal:  Proc Soc Exp Biol Med       Date:  1977-09

3.  Selective inhibition by somatostatin of cyclic AMP production in rat gastric glands: demonstration of a direct effect on the parietal cell function.

Authors:  C Gespach; C Dupont; D Bataille; G Rosselin
Journal:  FEBS Lett       Date:  1980-06-02       Impact factor: 4.124

4.  [Experimental studies on mechanisms of gastric acid secretion. Gastric acid secretion and role of cellular cyclic AMP in isolated guinea pig gastric glands].

Authors:  S Nishihara
Journal:  Nihon Shokakibyo Gakkai Zasshi       Date:  1984-06

5.  High biological activity of the synthetic replicates of somatostatin-28 and somatostatin-25.

Authors:  P Brazeau; N Ling; F Esch; P Böhlen; R Benoit; R Guillemin
Journal:  Regul Pept       Date:  1981-01

6.  Somatostatin is a potent activator of phosphoprotein phosphatases in the digestive tract.

Authors:  F Reyl; M J Lewin
Journal:  Biochim Biophys Acta       Date:  1981-07

7.  Direct inhibition of gastric acid by growth-hormone release-inhibiting hormone in dogs.

Authors:  A A Barros D'Sa; S R Bloom; J H Baron
Journal:  Lancet       Date:  1975-04-19       Impact factor: 79.321

8.  Somatostatin: abundance of immunoreactive hormone in rat stomach and pancreas.

Authors:  A Arimura; H Sato; A Dupont; N Nishi; A V Schally
Journal:  Science       Date:  1975-09-19       Impact factor: 47.728

9.  Forskolin potentiates calcium-dependent amylase secretion from rat pancreatic acinar cells.

Authors:  S Heisler
Journal:  Can J Physiol Pharmacol       Date:  1983-10       Impact factor: 2.273

10.  Inhibitory action of somatostatin on isolated gastric glands and parietal cells.

Authors:  C S Chew
Journal:  Am J Physiol       Date:  1983-08
View more
  2 in total

1.  Somatostatin receptors and the effect of somatostatin on histamine-stimulated adenylate cyclase activity in isolated gastric glands of guinea pigs.

Authors:  K Yoshida; S Nishihara; T Misawa; H Nawata
Journal:  Gastroenterol Jpn       Date:  1989-12

2.  Inhibitory effect of etintidine (BL-5641), a new type of H2 receptor antagonist, on binding of [3H]-cimetidine to plasma membrane and histamine-stimulated cellular cAMP production in isolated guinea pig gastric glands.

Authors:  S Nishihara; A Tanaka; A Tazoe; K Yoshida; T Misawa; H Ibayashi
Journal:  Gastroenterol Jpn       Date:  1986-04
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.