Literature DB >> 24175317

2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation.

Kate F Morgan1, Ian A Hollingsworth, James A Bull.   

Abstract

2-Sulfonyl-oxetanes have been prepared, affording non-planar structures with desirable physicochemical properties for fragment based drug discovery. The oxetane motif was formed by an intramolecular C-C bond formation. The fragments were further functionalised via organometallic intermediates at the intact oxetane and aromatic rings.

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Year:  2013        PMID： 24175317     DOI： 10.1039/c3cc46450d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Synthesis of di-, tri-, and tetrasubstituted oxetanes by rhodium-catalyzed O-H insertion and C-C bond-forming cyclization.

Authors:  Owen A Davis; James A Bull
Journal:  Angew Chem Int Ed Engl       Date:  2014-10-14       Impact factor: 15.336

2.  Structurally Divergent Lithium Catalyzed Friedel-Crafts Reactions on Oxetan-3-ols: Synthesis of 3,3-Diaryloxetanes and 2,3-Dihydrobenzofurans.

Authors:  Rosemary A Croft; James J Mousseau; Chulho Choi; James A Bull
Journal:  Chemistry       Date:  2016-10-10       Impact factor: 5.236

3.  Design and Synthesis of 56 Shape-Diverse 3D Fragments.

Authors:  Thomas D Downes; S Paul Jones; Hanna F Klein; Mary C Wheldon; Masakazu Atobe; Paul S Bond; James D Firth; Ngai S Chan; Laura Waddelove; Roderick E Hubbard; David C Blakemore; Claudia De Fusco; Stephen D Roughley; Lewis R Vidler; Maria Ann Whatton; Alison J-A Woolford; Gail L Wrigley; Peter O'Brien
Journal:  Chemistry       Date:  2020-07-08       Impact factor: 5.236

4.  Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.

Authors:  Sarah L Kidd; Elaine Fowler; Till Reinhardt; Thomas Compton; Natalia Mateu; Hector Newman; Dom Bellini; Romain Talon; Joseph McLoughlin; Tobias Krojer; Anthony Aimon; Anthony Bradley; Michael Fairhead; Paul Brear; Laura Díaz-Sáez; Katherine McAuley; Hannah F Sore; Andrew Madin; Daniel H O'Donovan; Kilian V M Huber; Marko Hyvönen; Frank von Delft; Christopher G Dowson; David R Spring
Journal:  Chem Sci       Date:  2020-05-14       Impact factor: 9.825

5.  Synthesis of Structurally Diverse N-Substituted Quaternary-Carbon-Containing Small Molecules from α,α-Disubstituted Propargyl Amino Esters.

Authors:  Natalia Mateu; Sarah L Kidd; Leen Kalash; Hannah F Sore; Andrew Madin; Andreas Bender; David R Spring
Journal:  Chemistry       Date:  2018-08-13       Impact factor: 5.236

6.  Chemical Space Exploration of Oxetanes.

Authors:  Fernando Rodrigues de Sá Alves; Rafael M Couñago; Stefan Laufer
Journal:  Int J Mol Sci       Date:  2020-11-02       Impact factor: 5.923
  6 in total

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