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Literature DB >> 24174263

Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.

Emilia C Calvaresi¹, Carlotta Granchi, Tiziano Tuccinardi, Valeria Di Bussolo, Robert W Huigens, Hyang Yeon Lee, Rahul Palchaudhuri, Marco Macchia, Adriano Martinelli, Filippo Minutolo, Paul J Hergenrother.

Abstract

Effective glucose diet: We report the development and activity of glucose-conjugated LDH-A inhibitors designed for dual targeting of the Warburg effect (elevated glucose uptake and glycolysis) in cancer cells. Glycoconjugation could be applied to inhibitors of many enzymes involved in glycolysis or tumor metabolism.

Entities: CellLine Chemical Disease Gene Species

Keywords: Warburg effect; cancer; drug design; glycoconjugation; targeted anticancer agents

Mesh：

Substances：

Year: 2013 PMID： 24174263 PMCID： PMC3919968 DOI： 10.1002/cbic.201300562

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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