Literature DB >> 24173506

The effect of paromomycin and [psi] on the suppression of mitochondrial mutations in Saccharomyces cerevisiae.

G Dujardin1, P Lund, P P Slonimski.   

Abstract

Paromomycin has been found to suppress certain nonsense mutations located in several mitochondrial genes in yeast. In the mosaic genes, paromomycin preferentially suppresses those mutations located in the introns. There is a strong correlation between this phenotypic suppression by paromomycin and the genetic suppression due to various informational mitoribosomal suppressors. No effect of the cytoplasmic element [psi] on mitoribosomal protein synthesis was observed. This work provides strong evidence for the translation of mRNA maturase proteins from open reading frames of the mitochondrial introns.

Entities:  

Year:  1984        PMID： 24173506     DOI： 10.1007/BF00396200

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  49 in total

1.  Recombinational analysis of oxi2 mutants and preliminary analysis of their translation products in S. cerevisiae.

Authors:  H Baranowska; B Szcześniak; A Ejchart; A Kruszewskal; M Claisse
Journal:  Curr Genet       Date:  1983-06       Impact factor: 3.886

2.  Mitochondrial and nuclear mitoribosomal suppressors that enable misreading of ochre codons in yeast mitochondria : I. Isolation, localization and allelism of suppressors.

Authors:  A Kruszewska; P P Slonimski
Journal:  Curr Genet       Date:  1984-12       Impact factor: 3.886

3.  Mitochondrial genetics. V. Multifactorial mitochondrial crosses involving a mutation conferring paromomycin-resistance in Saccharomyces cerevisiae.

Authors:  K Wolf; B Dujon; P P Slonimski
Journal:  Mol Gen Genet       Date:  1973-09-05

4.  Long range control circuits within mitochondria and between nucleus and mitochondria. I. Methodology and phenomenology of suppressors.

Authors:  G Dujardin; P Pajot; O Groudinsky; P P Slonimski
Journal:  Mol Gen Genet       Date:  1980

5.  A pathway of cytochrome b mRNA processing in yeast mitochondria: specific splicing steps and an intron-derived circular DNA.

Authors:  A Halbreich; P Pajot; M Foucher; C Grandchamp; P Slonimski
Journal:  Cell       Date:  1980-02       Impact factor: 41.582

6.  Selection of ribosomal mutants by antibiotic suppression in yeast.

Authors:  F T Bayliss; R T Vinopal
Journal:  Science       Date:  1971-12-24       Impact factor: 47.728

7.  The mitochondrial COB region in yeast codes for apocytochrome b and is mosaic.

Authors:  A Haid; R J Schweyen; H Bechmann; F Kaudewitz; M Solioz; G Schatz
Journal:  Eur J Biochem       Date:  1979-03

8.  Frameshifts and frameshift suppressors in Saccharomyces cerevisiae.

Authors:  M R Culbertson; L Charnas; M T Johnson; G R Fink
Journal:  Genetics       Date:  1977-08       Impact factor: 4.562

9.  Mutations affecting RNA splicing and the interaction of gene expression of the yeast mitochondrial loci cob and oxi-3.

Authors:  G J Van Ommen; P H Boer; G S Groot; M De Haan; E Roosendaal; L A Grivell; A Haid; R J Schweyen
Journal:  Cell       Date:  1980-05       Impact factor: 41.582

10.  Determination of functional domains in intron bI1 of yeast mitochondrial RNA by studies of mitochondrial mutations and a nuclear suppressor.

Authors:  C Schmelzer; C Schmidt; K May; R J Schweyen
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  2 in total

1.  Phenotypic suppression and nuclear accommodation of the mit- oxi1-V25 mutation in isolated yeast mitochondria.

Authors:  W Zagórski; M Boguta; M Mieszczak; M Claisse; B Guiard; A Spyridakis; P P Slonimski
Journal:  Curr Genet       Date:  1987       Impact factor: 3.886

2.  Nuclear omnipotent suppressors of premature termination codons in mitochondrial genes affect the 37S mitoribosomal subunit.

Authors:  M Boguta; M Mieszczak; W Zagórski
Journal:  Curr Genet       Date:  1988-02       Impact factor: 3.886
  2 in total

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