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Literature DB >> 24173285

The evolution of X chromosome inactivation in mammals: the demise of Ohno's hypothesis?

Eugénie Pessia¹, Jan Engelstädter, Gabriel A B Marais.

Abstract

Ohno's hypothesis states that dosage compensation in mammals evolved in two steps: a twofold hyperactivation of the X chromosome in both sexes to compensate for gene losses on the Y chromosome, and silencing of one X (X-chromosome inactivation, XCI) in females to restore optimal dosage. Recent tests of this hypothesis have returned contradictory results. In this review, we explain this ongoing controversy and argue that a novel view on dosage compensation evolution in mammals is starting to emerge. Ohno's hypothesis may be true for a few, dosage-sensitive genes only. If so few genes are compensated, then why has XCI evolved as a chromosome-wide mechanism? This and several other questions raised by the new data in mammals are discussed, and future research directions are proposed.

Mesh：

Year: 2013 PMID： 24173285 DOI： 10.1007/s00018-013-1499-6

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

69 in total

1. Sexual antagonism and the evolution of X chromosome inactivation.

Authors: Jan Engelstädter; David Haig
Journal: Evolution Date: 2008-05-27 Impact factor: 3.694

Review 2. The evolution of chromosomal sex determination and dosage compensation.

Authors: B Charlesworth
Journal: Curr Biol Date: 1996-02-01 Impact factor: 10.834

Review 3. Different flavors of X-chromosome inactivation in mammals.

Authors: Cathérine Dupont; Joost Gribnau
Journal: Curr Opin Cell Biol Date: 2013-04-08 Impact factor: 8.382

4. X-chromosome inactivation in monkey embryos and pluripotent stem cells.

Authors: Masahito Tachibana; Hong Ma; Michelle L Sparman; Hyo-Sang Lee; Cathy M Ramsey; Joy S Woodward; Hathaitip Sritanaudomchai; Keith R Masterson; Erin E Wolff; Yibing Jia; Shoukhrat M Mitalipov
Journal: Dev Biol Date: 2012-08-23 Impact factor: 3.582

5. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome.

Authors: Jesse M Engreitz; Amy Pandya-Jones; Patrick McDonel; Alexander Shishkin; Klara Sirokman; Christine Surka; Sabah Kadri; Jeffrey Xing; Alon Goren; Eric S Lander; Kathrin Plath; Mitchell Guttman
Journal: Science Date: 2013-07-04 Impact factor: 47.728

Review 6. Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration.

Authors: Doris Bachtrog
Journal: Nat Rev Genet Date: 2013-02 Impact factor: 53.242

7. The relationship among gene expression, the evolution of gene dosage, and the rate of protein evolution.

Authors: Jean-François Gout; Daniel Kahn; Laurent Duret
Journal: PLoS Genet Date: 2010-05-13 Impact factor: 5.917

8. Large-scale population study of human cell lines indicates that dosage compensation is virtually complete.

Authors: Colette M Johnston; Frances L Lovell; Daniel A Leongamornlert; Barbara E Stranger; Emmanouil T Dermitzakis; Mark T Ross
Journal: PLoS Genet Date: 2007-12-13 Impact factor: 5.917

9. Independent evolution of transcriptional inactivation on sex chromosomes in birds and mammals.

Authors: Alexandra M Livernois; Shafagh A Waters; Janine E Deakin; Jennifer A Marshall Graves; Paul D Waters
Journal: PLoS Genet Date: 2013-07-18 Impact factor: 5.917

10. Chromosome-wide profiling of X-chromosome inactivation and epigenetic states in fetal brain and placenta of the opossum, Monodelphis domestica.

Authors: Xu Wang; Kory C Douglas; John L Vandeberg; Andrew G Clark; Paul B Samollow
Journal: Genome Res Date: 2013-09-24 Impact factor: 9.043

24 in total

Review 1. Evolution of vertebrate sex chromosomes and dosage compensation.

Authors: Jennifer A Marshall Graves
Journal: Nat Rev Genet Date: 2015-11-30 Impact factor: 53.242

Review 2. Dosage compensation evolution in plants: theories, controversies and mechanisms.

Authors: Aline Muyle; Gabriel A B Marais; Václav Bačovský; Roman Hobza; Thomas Lenormand
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2022-03-21 Impact factor: 6.237

Review 3. Gene regulation in time and space during X-chromosome inactivation.

Authors: Agnese Loda; Samuel Collombet; Edith Heard
Journal: Nat Rev Mol Cell Biol Date: 2022-01-10 Impact factor: 113.915

Review 4. Avian sex, sex chromosomes, and dosage compensation in the age of genomics.

Authors: Jennifer A Marshall Graves
Journal: Chromosome Res Date: 2014-04 Impact factor: 5.239

Review 5. Dosage compensation of the sex chromosomes and autosomes.

Authors: Christine M Disteche
Journal: Semin Cell Dev Biol Date: 2016-04-22 Impact factor: 7.727

6. Status of dosage compensation of X chromosome in bovine genome.

Authors: Sojeong Ka; Hyeonju Ahn; Minseok Seo; Heebal Kim; Jin Nam Kim; Hyun-Jeong Lee
Journal: Genetica Date: 2016-07-04 Impact factor: 1.082

7. Evolution of gene dosage on the Z-chromosome of schistosome parasites.

Authors: Marion A L Picard; Celine Cosseau; Sabrina Ferré; Thomas Quack; Christoph G Grevelding; Yohann Couté; Beatriz Vicoso
Journal: Elife Date: 2018-07-25 Impact factor: 8.140

Review 8. Epigenetics drive the evolution of sex chromosomes in animals and plants.

Authors: Aline Muyle; Doris Bachtrog; Gabriel A B Marais; James M A Turner
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2021-04-19 Impact factor: 6.671

9. Increased expression of X-linked genes in mammals is associated with a higher stability of transcripts and an increased ribosome density.

Authors: Marie-Line Faucillion; Jan Larsson
Journal: Genome Biol Evol Date: 2015-03-18 Impact factor: 3.416

10. Partial dosage compensation in Strepsiptera, a sister group of beetles.

Authors: Shivani Mahajan; Doris Bachtrog
Journal: Genome Biol Evol Date: 2015-01-18 Impact factor: 3.416