Literature DB >> 24164298

H2AX a promising biomarker for lung cancer: a review.

D Matthaios1, P Hountis, P Karakitsos, D Bouros, S Kakolyris.   

Abstract

Histone's H2A variant (H2AX) phosphorylation is an early indicator of DNA double-strand breaks formation and DNA damage response. Thus, it may act as a novel biomarker to monitor genotoxic events that can drive cancer development and tumor progression. This review will focus on the possible applications of H2AX as a key regulator of DNA damage response in lung cancer and as a biomarker of: sensitivity of lung tumors to chemotherapy and radiotherapy, treatment with PARP inhibitors, bystander effect, multistep lung carcinogenesis, environmental smoking, and chemical genotoxicity, chemoprevention, prognosis, and also as therapeutic targets in lung cancers.

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Year:  2013        PMID： 24164298     DOI： 10.3109/07357907.2013.849721

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  13 in total

1.  Evaluation of Severe Combined Immunodeficiency and Combined Immunodeficiency Pediatric Patients on the Basis of Cellular Radiosensitivity.

Authors:  Pavel Lobachevsky; Lisa Woodbine; Kuang-Chih Hsiao; Sharon Choo; Chris Fraser; Paul Gray; Jai Smith; Nickala Best; Laura Munforte; Elena Korneeva; Roger F Martin; Penny A Jeggo; Olga A Martin
Journal:  J Mol Diagn       Date:  2015-07-04       Impact factor: 5.568

2.  Knockdown of TOR signaling pathway regulator suppresses cell migration and invasion in non-small cell lung cancer via the regulation of epithelial-to-mesenchymal transition.

Authors:  Xiang Xu; Huangkai Zhu; Minglei Yang; Enkuo Zheng; Yinjie Zhou; Junjun Ni; Rui Li; Zhenhua Yang; Ti He; Guofang Zhao
Journal:  Exp Ther Med       Date:  2019-12-20       Impact factor: 2.447

Review 3.  MicroRNAs Involved in Small-cell Lung Cancer as Possible Agents for Treatment and Identification of New Targets.

Authors:  Ulrich H Weidle; Adam Nopora
Journal:  Cancer Genomics Proteomics       Date:  2021 Sep-Oct       Impact factor: 4.069

4.  Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.

Authors:  Tao Ren; Jinlu Shan; Mengxia Li; Yi Qing; Chengyuan Qian; Guangjie Wang; Qing Li; Guoshou Lu; Chongyi Li; Yu Peng; Hao Luo; Shiheng Zhang; Yuxing Yang; Yi Cheng; Dong Wang; Shu-Feng Zhou
Journal:  Drug Des Devel Ther       Date:  2015-06-08       Impact factor: 4.162

5.  Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma.

Authors:  Jin-Lin Hu; Si-Si Hu; Xiu-Xiu Hou; Xin Zhu; Jun Cao; Lie-Hao Jiang; Ming-Hua Ge
Journal:  Int J Endocrinol       Date:  2015-03-16       Impact factor: 3.257

6.  Short-term markers of DNA damage among roofers who work with hot asphalt.

Authors:  Berrin Serdar; Stephen Brindley; Greg Dooley; John Volckens; Elizabeth Juarez-Colunga; Ryan Gan
Journal:  Environ Health       Date:  2016-10-20       Impact factor: 5.984

7.  Twist1 promotes radioresistance in nasopharyngeal carcinoma.

Authors:  Linli Zhang; Beibei Su; Wei Sun; Wenwen Li; Min Luo; Dongbo Liu; Qi Mei; Guoxian Long; Guangyuan Hu; Guoqing Hu
Journal:  Oncotarget       Date:  2016-12-06

8.  A robust six-gene prognostic signature for prediction of both disease-free and overall survival in non-small cell lung cancer.

Authors:  Shuguang Zuo; Min Wei; Hailin Zhang; Anxian Chen; Junhua Wu; Jiwu Wei; Jie Dong
Journal:  J Transl Med       Date:  2019-05-14       Impact factor: 5.531

9.  Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells.

Authors:  Małgorzata Girek; Karol Kłosiński; Bartłomiej Grobelski; Stefania Pizzimenti; Marie Angele Cucci; Martina Daga; Giuseppina Barrera; Zbigniew Pasieka; Kamila Czarnecka; Paweł Szymański
Journal:  Mol Cell Biochem       Date:  2019-07-16       Impact factor: 3.396

10.  Characterization of the Tyrosine Kinase-Regulated Proteome in Breast Cancer by Combined use of RNA interference (RNAi) and Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) Quantitative Proteomics.

Authors:  Justin Stebbing; Hua Zhang; Yichen Xu; Arnhild Grothey; Paul Ajuh; Nicos Angelopoulos; Georgios Giamas
Journal:  Mol Cell Proteomics       Date:  2015-06-18       Impact factor: 5.911
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