BACKGROUND: Although interleukin-10 (IL-10) is a potent inhibitor of allergic diseases, the association between promoter -1082/-819/-592 polymorphisms and asthma susceptibility remains inconclusive. We sought to determine if IL-10 promoter -1082/-819/-592 polymorphisms contribute to asthma susceptibility and are associated with phenotypes of atopic asthma. METHODS: Systematic computerized searches were performed. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated by using random-effect and fixed-effect models, based on between-study heterogeneity. Subgroup analyses were performed according to age, ethnicity, and atopy. Publication bias was detected by funnel plot using Egger's test. RESULTS: A total of 4,716 asthmatic patients and 5,093 controls were included. The asthma susceptibility correlated significantly with IL-10 promoter gene -1082 polymorphism [OR (95 % CI) 1.26 (1.02, 1.55) for AA vs. AG + GG] and -592 polymorphism [OR (95 % CI) 1.12 (1.07, 1.34) for AC + AA vs. CC] (both P < 0.05), but not with -819 polymorphism (P > 0.05). Subgroup analyzes suggested that the AA versus AG + GG genotype of -1082A/G polymorphism and AC + AA versus CC genotype of -592A/C polymorphism contributed significantly to increased asthma susceptibility in adults [OR (95 % CI) 1.39 (1.03, 1.87) for -1082A/G and 1.53 (1.25, 1.87) for -592A/C polymorphism]. The Asian population [OR (95 % CI) 1.35 (1.1, 1.7) for -1082A/G and 1.4 (1.12, 1.64) for -592A/C polymorphism] and subjects with atopic asthma [OR (95 % CI) 1.49 (1.18, 1.88) for -1082A/G and 1.23 (1.01, 1.48) for -592A/C polymorphism] also had an increased susceptibility of asthma. No publication bias was detected. CONCLUSIONS: IL-10 promoter -1028A/G, -592A/C polymorphisms and their haplotypes, but not -819T/C polymorphism, correlate with asthma susceptibility.
BACKGROUND: Although interleukin-10 (IL-10) is a potent inhibitor of allergic diseases, the association between promoter -1082/-819/-592 polymorphisms and asthma susceptibility remains inconclusive. We sought to determine if IL-10 promoter -1082/-819/-592 polymorphisms contribute to asthma susceptibility and are associated with phenotypes of atopic asthma. METHODS: Systematic computerized searches were performed. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated by using random-effect and fixed-effect models, based on between-study heterogeneity. Subgroup analyses were performed according to age, ethnicity, and atopy. Publication bias was detected by funnel plot using Egger's test. RESULTS: A total of 4,716 asthmatic patients and 5,093 controls were included. The asthma susceptibility correlated significantly with IL-10 promoter gene -1082 polymorphism [OR (95 % CI) 1.26 (1.02, 1.55) for AA vs. AG + GG] and -592 polymorphism [OR (95 % CI) 1.12 (1.07, 1.34) for AC + AA vs. CC] (both P < 0.05), but not with -819 polymorphism (P > 0.05). Subgroup analyzes suggested that the AA versus AG + GG genotype of -1082A/G polymorphism and AC + AA versus CC genotype of -592A/C polymorphism contributed significantly to increased asthma susceptibility in adults [OR (95 % CI) 1.39 (1.03, 1.87) for -1082A/G and 1.53 (1.25, 1.87) for -592A/C polymorphism]. The Asian population [OR (95 % CI) 1.35 (1.1, 1.7) for -1082A/G and 1.4 (1.12, 1.64) for -592A/C polymorphism] and subjects with atopic asthma [OR (95 % CI) 1.49 (1.18, 1.88) for -1082A/G and 1.23 (1.01, 1.48) for -592A/C polymorphism] also had an increased susceptibility of asthma. No publication bias was detected. CONCLUSIONS:IL-10 promoter -1028A/G, -592A/C polymorphisms and their haplotypes, but not -819T/C polymorphism, correlate with asthma susceptibility.
Authors: Denise Daley; Mathieu Lemire; Loubna Akhabir; Moira Chan-Yeung; Jian Qing He; Treena McDonald; Andrew Sandford; Dorota Stefanowicz; Ben Tripp; David Zamar; Yohan Bosse; Vincent Ferretti; Alexandre Montpetit; Marie-Catherine Tessier; Allan Becker; Anita L Kozyrskyj; John Beilby; Pamela A McCaskie; Bill Musk; Nicole Warrington; Alan James; Catherine Laprise; Lyle J Palmer; Peter D Paré; Thomas J Hudson Journal: Hum Genet Date: 2009-02-27 Impact factor: 4.132
Authors: H Hakonarson; U S Bjornsdottir; E Ostermann; T Arnason; A E Adalsteinsdottir; E Halapi; D Shkolny; K Kristjansson; S A Gudnadottir; M L Frigge; D Gislason; T Gislason; A Kong; J Gulcher; K Stefansson Journal: Am J Respir Crit Care Med Date: 2001-12-01 Impact factor: 21.405
Authors: Elena Yu Bragina; Evgeny S Tiys; Maxim B Freidin; Lada A Koneva; Pavel S Demenkov; Vladimir A Ivanisenko; Nikolay A Kolchanov; Valery P Puzyrev Journal: Immunogenetics Date: 2014-06-24 Impact factor: 2.846
Authors: Annukka Holster; Johanna Teräsjärvi; Juho Vuononvirta; Petri Koponen; Ville Peltola; Merja Helminen; Qiushui He; Matti Korppi; Kirsi Nuolivirta Journal: World J Pediatr Date: 2018-05-25 Impact factor: 2.764
Authors: Peter W Heymann; Huyen-Tran Nguyen; John W Steinke; Ronald B Turner; Judith A Woodfolk; Thomas A E Platts-Mills; Lisa Martin; Hua He; Jocelyn Biagini Myers; Mark Lindsey; Umasundari Sivaprasad; Mario Medvedovic; Naim Mahi; Holliday Carper; Deborah D Murphy; James Patrie; Gurjit K Khurana Hershey Journal: PLoS One Date: 2017-05-26 Impact factor: 3.240