| Literature DB >> 24162736 |
Mingzhou Li1, Shilin Tian, Long Jin, Guangyu Zhou, Ying Li, Yuan Zhang, Tao Wang, Carol K L Yeung, Lei Chen, Jideng Ma, Jinbo Zhang, Anan Jiang, Ji Li, Chaowei Zhou, Jie Zhang, Yingkai Liu, Xiaoqing Sun, Hongwei Zhao, Zexiong Niu, Pinger Lou, Lingjin Xian, Xiaoyong Shen, Shaoqing Liu, Shunhua Zhang, Mingwang Zhang, Li Zhu, Surong Shuai, Lin Bai, Guoqing Tang, Haifeng Liu, Yanzhi Jiang, Miaomiao Mai, Jian Xiao, Xun Wang, Qi Zhou, Zhiquan Wang, Paul Stothard, Ming Xue, Xiaolian Gao, Zonggang Luo, Yiren Gu, Hongmei Zhu, Xiaoxiang Hu, Yaofeng Zhao, Graham S Plastow, Jinyong Wang, Zhi Jiang, Kui Li, Ning Li, Xuewei Li, Ruiqiang Li.
Abstract
We report the sequencing at 131× coverage, de novo assembly and analyses of the genome of a female Tibetan wild boar. We also resequenced the whole genomes of 30 Tibetan wild boars from six major distributed locations and 18 geographically related pigs in China. We characterized genetic diversity, population structure and patterns of evolution. We searched for genomic regions under selection, which includes genes that are involved in hypoxia, olfaction, energy metabolism and drug response. Comparing the genome of Tibetan wild boar with those of neighboring Chinese domestic pigs further showed the impact of thousands of years of artificial selection and different signatures of selection in wild boar and domestic pig. We also report genetic adaptations in Tibetan wild boar that are associated with high altitudes and characterize the genetic basis of increased salivation in domestic pig.Entities:
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Year: 2013 PMID： 24162736 DOI： 10.1038/ng.2811
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330