Literature DB >> 24159216

A pharmacogenetics service experience for pharmacy students, residents, and fellows.

Katarzyna Drozda1, Yana Labinov, Ruixuan Jiang, Margaret R Thomas, Shan S Wong, Shitalben Patel, Edith A Nutescu, Larisa H Cavallari.   

Abstract

OBJECTIVE: To utilize a comprehensive, pharmacist-led warfarin pharmacogenetics service to provide pharmacy students, residents, and fellows with clinical and research experiences involving genotype-guided therapy.
DESIGN: First-year (P1) through fourth-year (P4) pharmacy students, pharmacy residents, and pharmacy fellows participated in a newly implemented warfarin pharmacogenetics service in a hospital setting. Students, residents, and fellows provided genotype-guided dosing recommendations as part of clinical care, or analyzed samples and data collected from patients on the service for research purposes. ASSESSMENT: Students', residents', and fellows' achievement of learning objectives was assessed using a checklist based on established core competencies in pharmacogenetics. The mean competency score of the students, residents, and fellows who completed a clinical and/or research experience with the service was 97% ±3%.
CONCLUSION: A comprehensive warfarin pharmacogenetics service provided unique experiential and research opportunities for pharmacy students, residents, and fellows and sufficiently addressed a number of core competencies in pharmacogenetics.

Entities:  

Keywords:  pharmacogenetics; pharmacy service; research; warfarin

Mesh:

Substances:

Year:  2013        PMID: 24159216      PMCID: PMC3806959          DOI: 10.5688/ajpe778175

Source DB:  PubMed          Journal:  Am J Pharm Educ        ISSN: 0002-9459            Impact factor:   2.047


  26 in total

1.  The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans.

Authors:  M A Perera; E Gamazon; L H Cavallari; S R Patel; S Poindexter; R A Kittles; D Nicolae; N J Cox
Journal:  Clin Pharmacol Ther       Date:  2011-01-26       Impact factor: 6.875

2.  Pharmacogenomics in the curricula of colleges and schools of pharmacy in the United States.

Authors:  John E Murphy; James S Green; Laura A Adams; Robert B Squire; Grace M Kuo; Alan McKay
Journal:  Am J Pharm Educ       Date:  2010-02-10       Impact factor: 2.047

3.  Assessment of the pharmacogenomics educational needs of pharmacists.

Authors:  Kristen B McCullough; Christine M Formea; Kevin D Berg; Julianna A Burzynski; Julie L Cunningham; Narith N Ou; Maria I Rudis; Joanna L Stollings; Wayne T Nicholson
Journal:  Am J Pharm Educ       Date:  2011-04-11       Impact factor: 2.047

4.  Development and evaluation of a pharmacogenomics educational program for pharmacists.

Authors:  Christine M Formea; Wayne T Nicholson; Kristen B McCullough; Kevin D Berg; Melody L Berg; Julie L Cunningham; Julianna A Merten; Narith N Ou; Joanna L Stollings
Journal:  Am J Pharm Educ       Date:  2013-02-12       Impact factor: 2.047

5.  Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups.

Authors:  Nita A Limdi; Mia Wadelius; Larisa Cavallari; Niclas Eriksson; Dana C Crawford; Ming-Ta M Lee; Chien-Hsiun Chen; Alison Motsinger-Reif; Hersh Sagreiya; Nianjun Liu; Alan H B Wu; Brian F Gage; Andrea Jorgensen; Munir Pirmohamed; Jae-Gook Shin; Guilherme Suarez-Kurtz; Stephen E Kimmel; Julie A Johnson; Teri E Klein; Michael J Wagner
Journal:  Blood       Date:  2010-03-04       Impact factor: 22.113

Review 6.  Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing.

Authors:  J A Johnson; L Gong; M Whirl-Carrillo; B F Gage; S A Scott; C M Stein; J L Anderson; S E Kimmel; M T M Lee; M Pirmohamed; M Wadelius; T E Klein; R B Altman
Journal:  Clin Pharmacol Ther       Date:  2011-09-07       Impact factor: 6.875

7.  In-vitro and in-vivo effects of the CYP2C9*11 polymorphism on warfarin metabolism and dose.

Authors:  Guoying Tai; Frederico Farin; Mark J Rieder; Albert W Dreisbach; David L Veenstra; Christophe L M J Verlinde; Allan E Rettie
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8.  A required course in human genomics, pharmacogenomics, and bioinformatics.

Authors:  Daniel A Brazeau; Gayle A Brazeau
Journal:  Am J Pharm Educ       Date:  2006-12-15       Impact factor: 2.047

9.  Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.

Authors:  B F Gage; C Eby; J A Johnson; E Deych; M J Rieder; P M Ridker; P E Milligan; G Grice; P Lenzini; A E Rettie; C L Aquilante; L Grosso; S Marsh; T Langaee; L E Farnett; D Voora; D L Veenstra; R J Glynn; A Barrett; H L McLeod
Journal:  Clin Pharmacol Ther       Date:  2008-02-27       Impact factor: 6.875

10.  Recommendations of core competencies in genetics essential for all health professionals.

Authors: 
Journal:  Genet Med       Date:  2001 Mar-Apr       Impact factor: 8.822

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  9 in total

1.  Proposal for a pharmacogenetics certificate program for pharmacists.

Authors:  Susanne B Haga; Jivan Moaddeb
Journal:  Pharmacogenomics       Date:  2016-03-29       Impact factor: 2.533

2.  An Effective Approach to Teaching Pharmacogenomics in the First Year of Pharmacy Curriculum.

Authors:  Marina Gálvez-Peralta; Grazyna D Szklarz; Werner J Geldenhuys; Paul R Lockman
Journal:  Am J Pharm Educ       Date:  2018-10       Impact factor: 2.047

3.  Race-Specific Influence of CYP4F2 on Dose and Risk of Hemorrhage Among Warfarin Users.

Authors:  Aditi Shendre; Todd M Brown; Nianjun Liu; Charles E Hill; T Mark Beasley; Deborah A Nickerson; Nita A Limdi
Journal:  Pharmacotherapy       Date:  2016-03-14       Impact factor: 4.705

Review 4.  Educational strategies to enable expansion of pharmacogenomics-based care.

Authors:  Kristin Wiisanen Weitzel; Christina L Aquilante; Samuel Johnson; David F Kisor; Philip E Empey
Journal:  Am J Health Syst Pharm       Date:  2016-12-01       Impact factor: 2.637

Review 5.  Challenges to integrating pharmacogenetic testing into medication therapy management.

Authors:  Susanne B Haga; Nancy M Allen LaPointe; Jivan Moaddeb
Journal:  J Manag Care Spec Pharm       Date:  2015-04

6.  AdvoCaring: A Cocurricular Program to Provide Advocacy and Caring to Underserved Populations in Baltimore.

Authors:  Michelle A Fritsch; Nathan Culver; Nicole Culhane; Jonathan Thigpen; Anne Lin
Journal:  Am J Pharm Educ       Date:  2016-09-25       Impact factor: 2.047

Review 7.  CYP2C19 polymorphisms and therapeutic drug monitoring of voriconazole: are we ready for clinical implementation of pharmacogenomics?

Authors:  Aniwaa Owusu Obeng; Eric F Egelund; Abdullah Alsultan; Charles A Peloquin; Julie A Johnson
Journal:  Pharmacotherapy       Date:  2014-02-07       Impact factor: 4.705

Review 8.  Emerging roles for pharmacists in clinical implementation of pharmacogenomics.

Authors:  Aniwaa Owusu-Obeng; Kristin W Weitzel; Randy C Hatton; Benjamin J Staley; Jennifer Ashton; Rhonda M Cooper-Dehoff; Julie A Johnson
Journal:  Pharmacotherapy       Date:  2014-09-15       Impact factor: 4.705

9.  Pharmacogenomics: From classroom to practice.

Authors:  Samantha C Nutter; Marina Gálvez-Peralta
Journal:  Mol Genet Genomic Med       Date:  2018-05-31       Impact factor: 2.183

  9 in total

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