Literature DB >> 24157626

The therapeutic effects of human adipose-derived stem cells in Alzheimer's disease mouse models.

Keun-A Chang1, Hee Jin Kim, Yuyoung Joo, Sungji Ha, Yoo-Hun Suh.   

Abstract

Alzheimer's disease (AD) is an irreversible neurodegenerative disease, still lacking proper clinical treatment. Therefore, many researchers have focused on the possibility of therapeutic use of stem cells for AD. Adipose-derived stem cells (ASCs), mesenchymal stem cells (MSCs) isolated from adipose tissue, are well known for their pluripotency and their ability to differentiate into multiple tissue types and have immune modulatory properties similar to those of MSCs from other origins. Because of their biological properties, ASCs can be considered for cell therapy and neuroregeneration. Our recent results clearly showed the therapeutic potential of these cells after transplantation into Tg2576 mice (an AD mouse model). Intravenously or intracerebrally transplanted human ASCs (hASCs) greatly improved the memory impairment and the neuropathology, suggesting that hASCs have a high therapeutic potential for AD.

Entities:  

Mesh：

Year:  2013        PMID： 24157626     DOI： 10.1159/000355261

Source DB:  PubMed          Journal:  Neurodegener Dis        ISSN： 1660-2854            Impact factor:   2.977


  12 in total

1.  Protective effect of Photobiomodulation Therapy and Bone Marrow Stromal Stem Cells Conditioned Media on Pheochromocytoma Cell Line 12 Against Oxidative Stress Induced by Hydrogen Peroxide.

Authors:  Shahrokh Khoshsirat; Hojjat Allah Abbaszadeh; Maryam Sadat Khoramgah; Shahram Darabi; Vahid Mansouri; Navid Ahmady-Roozbahany; Behnaz Ahrabi; Maryam Bahrami; Saeed Vafaee; Foozhan Tahmasebinia; Mahnaz Poor Hassan
Journal:  J Lasers Med Sci       Date:  2019-07-06

Review 2.  Adipose-Derived Mesenchymal Stem Cells Combined With Extracellular Vesicles May Improve Amyotrophic Lateral Sclerosis.

Authors:  Xichen Wang; Yong Zhang; Tian Jin; Benson O A Botchway; Ruihua Fan; Lvxia Wang; Xuehong Liu
Journal:  Front Aging Neurosci       Date:  2022-05-18       Impact factor: 5.702

3.  Testing alternatives: the use of adipose-derived mesenchymal stem cells to slow neurodegeneration in a rat model of Parkinson's disease.

Authors:  Fatma Y Meligy; Dalia A Elgamal; Eman S H Abd Allah; Naglaa K Idriss; Nagwa M Ghandour; Ehab M R Bayoumy; Azza Sayed Abdelrehim Khalil; Mohamed M El Fiky; Mostafa Elkhashab
Journal:  Mol Biol Rep       Date:  2019-08-08       Impact factor: 2.316

4.  Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients.

Authors:  Christopher Duma; Oleg Kopyov; Alex Kopyov; Mark Berman; Elliot Lander; Michael Elam; Michael Arata; David Weiland; Ruslana Cannell; Chad Caraway; Sean Berman; Kristin Scord; Lian Stemler; Karlyssa Chung; Samuel Khoudari; Rory McRory; Chace Duma; Sawyer Farmer; Anthony Bravo; Christian Yassa; Ami Sanathara; Elisa Singh; Benjamin Rapaport
Journal:  Mol Biol Rep       Date:  2019-07-20       Impact factor: 2.316

5.  Intranasal Administration of Mesenchymal Stem Cells Ameliorates the Abnormal Dopamine Transmission System and Inflammatory Reaction in the R6/2 Mouse Model of Huntington Disease.

Authors:  Libo Yu-Taeger; Janice Stricker-Shaver; Katrin Arnold; Patrycja Bambynek-Dziuk; Arianna Novati; Elisabeth Singer; Ali Lourhmati; Claire Fabian; Janine Magg; Olaf Riess; Matthias Schwab; Alexandra Stolzing; Lusine Danielyan; Hoa Huu Phuc Nguyen
Journal:  Cells       Date:  2019-06-15       Impact factor: 6.600

6.  Current status and future prospects of stem cell therapy in Alzheimer's disease.

Authors:  Fu-Qiang Zhang; Jin-Lan Jiang; Jing-Tian Zhang; Han Niu; Xue-Qi Fu; Lin-Lin Zeng
Journal:  Neural Regen Res       Date:  2020-02       Impact factor: 5.135

7.  Neuroprotective effects of Wharton's jelly-derived mesenchymal stem cells on motor deficits due to Parkinson's disease.

Authors:  Maryam Sadat Jalali; Alireza Sarkaki; Yaghoub Farbood; Seyed Saeed Azandeh; Esrafil Mansouri; Mohammad Ghasemi Dehcheshmeh; Ghasem Saki
Journal:  Iran J Basic Med Sci       Date:  2021-09       Impact factor: 2.699

Review 8.  From bench to bedside: use of human adipose-derived stem cells.

Authors:  Vaughan Feisst; Sarah Meidinger; Michelle B Locke
Journal:  Stem Cells Cloning       Date:  2015-11-02

9.  Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer's Disease.

Authors:  Jiri Ruzicka; Magdalena Kulijewicz-Nawrot; Jose Julio Rodrigez-Arellano; Pavla Jendelova; Eva Sykova
Journal:  Int J Mol Sci       Date:  2016-01-25       Impact factor: 5.923

10.  Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice.

Authors:  Olena Lykhmus; Lyudmyla Koval; Larysa Voytenko; Kateryna Uspenska; Serhiy Komisarenko; Olena Deryabina; Nadia Shuvalova; Vitalii Kordium; Alina Ustymenko; Vitalii Kyryk; Maryna Skok
Journal:  Front Pharmacol       Date:  2019-04-17       Impact factor: 5.810
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