Literature DB >> 24155317

Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection.

Shaoping Hou1, Veronica J Tom, Lori Graham, Paul Lu, Armin Blesch.   

Abstract

High-level spinal cord injury can lead to cardiovascular dysfunction, including disordered hemodynamics at rest and autonomic dysreflexia during noxious stimulation. To restore supraspinal control of sympathetic preganglionic neurons (SPNs), we grafted embryonic brainstem-derived neural stem cells (BS-NSCs) or spinal cord-derived neural stem cells (SC-NSCs) expressing green fluorescent protein into the T4 complete transection site of adult rats. Animals with injury alone served as controls. Implanting of BS-NSCs but not SC-NSCs resulted in recovery of basal cardiovascular parameters, whereas both cell grafts alleviated autonomic dysreflexia. Subsequent spinal cord retransection above the graft abolished the recovery of basal hemodynamics and reflexic response. BS-NSC graft-derived catecholaminergic and serotonergic neurons showed remarkable long-distance axon growth and topographical innervation of caudal SPNs. Anterograde tracing indicated growth of medullar axons into stem cell grafts and formation of synapses. Thus, grafted embryonic brainstem-derived neurons can act as functional relays to restore supraspinal regulation of denervated SPNs, thereby contributing to cardiovascular functional improvement.

Entities:  

Mesh：

Year:  2013        PMID： 24155317      PMCID： PMC3807033          DOI： 10.1523/JNEUROSCI.2851-13.2013

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  56 in total

Review 1.  What drives the tonic activity of presympathetic neurons in the rostral ventrolateral medulla?

Authors:  R A Dampney; T Tagawa; J Horiuchi; P D Potts; M Fontes; J W Polson
Journal:  Clin Exp Pharmacol Physiol       Date:  2000-12       Impact factor: 2.557

2.  Cardiovascular and temperature changes in spinal cord injured rats at rest and during autonomic dysreflexia.

Authors:  A S Laird; P Carrive; P M E Waite
Journal:  J Physiol       Date:  2006-09-14       Impact factor: 5.182

Review 3.  Bulbospinal serotonergic pathways in the control of blood pressure.

Authors:  J H Coote
Journal:  J Cardiovasc Pharmacol       Date:  1990       Impact factor: 3.105

4.  Relationship between severity of spinal cord injury and abnormalities in neurogenic cardiovascular control in conscious rats.

Authors:  D N Maiorov; M G Fehlings; A V Krassioukov
Journal:  J Neurotrauma       Date:  1998-05       Impact factor: 5.269

5.  Axonal projections between fetal spinal cord transplants and the adult rat spinal cord: a neuroanatomical tracing study of local interactions.

Authors:  L B Jakeman; P J Reier
Journal:  J Comp Neurol       Date:  1991-05-08       Impact factor: 3.215

6.  Inhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin alphaD: a potential new anti-inflammatory treatment.

Authors:  P J Mabon; L C Weaver; G A Dekaban
Journal:  Exp Neurol       Date:  2000-11       Impact factor: 5.330

7.  Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats.

Authors:  Eveline Bruinstroop; Georgina Cano; Veronique G J M Vanderhorst; Judney C Cavalcante; Jena Wirth; Miguel Sena-Esteves; Clifford B Saper
Journal:  J Comp Neurol       Date:  2012-06-15       Impact factor: 3.215

8.  Spinal cord serotonin receptors in cardiovascular regulation and potentiation of the pressor response to intrathecal substance P after serotonin depletion.

Authors:  H Hasséssian; P Poulat; E Hamel; T A Reader; R Couture
Journal:  Can J Physiol Pharmacol       Date:  1993-07       Impact factor: 2.273

9.  Neutralizing intraspinal nerve growth factor with a trkA-IgG fusion protein blocks the development of autonomic dysreflexia in a clip-compression model of spinal cord injury.

Authors:  Daniel R Marsh; Sharon T Wong; Susan O Meakin; James I S MacDonald; Eilis F Hamilton; Lynne C Weaver
Journal:  J Neurotrauma       Date:  2002-12       Impact factor: 5.269

10.  Plasticity of lumbosacral propriospinal neurons is associated with the development of autonomic dysreflexia after thoracic spinal cord transection.

Authors:  Shaoping Hou; Hanad Duale; Adrian A Cameron; Sarah M Abshire; Travis S Lyttle; Alexander G Rabchevsky
Journal:  J Comp Neurol       Date:  2008-08-01       Impact factor: 3.215
View more
  24 in total

1.  Dopamine is produced in the rat spinal cord and regulates micturition reflex after spinal cord injury.

Authors:  Shaoping Hou; David M Carson; Di Wu; Michelle C Klaw; John D Houlé; Veronica J Tom
Journal:  Exp Neurol       Date:  2015-12-02       Impact factor: 5.330

2.  Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates.

Authors:  Hiroki Iwai; Hiroko Shimada; Soraya Nishimura; Yoshiomi Kobayashi; Go Itakura; Keiko Hori; Keigo Hikishima; Hayao Ebise; Naoko Negishi; Shinsuke Shibata; Sonoko Habu; Yoshiaki Toyama; Masaya Nakamura; Hideyuki Okano
Journal:  Stem Cells Transl Med       Date:  2015-05-27       Impact factor: 6.940

Review 3.  Rewiring the spinal cord: Direct and indirect strategies.

Authors:  Maria Teresa Dell'Anno; Stephen M Strittmatter
Journal:  Neurosci Lett       Date:  2016-12-19       Impact factor: 3.046

4.  Integration of Transplanted Neural Precursors with the Injured Cervical Spinal Cord.

Authors:  Victoria M Spruance; Lyandysha V Zholudeva; Kristiina M Hormigo; Margo L Randelman; Tatiana Bezdudnaya; Vitaliy Marchenko; Michael A Lane
Journal:  J Neurotrauma       Date:  2018-04-24       Impact factor: 5.269

Review 5.  Repair of spinal cord injury with neuronal relays: From fetal grafts to neural stem cells.

Authors:  Joseph F Bonner; Oswald Steward
Journal:  Brain Res       Date:  2015-01-12       Impact factor: 3.252

6.  A radio-telemetric system to monitor cardiovascular function in rats with spinal cord transection and embryonic neural stem cell grafts.

Authors:  Shaoping Hou; Armin Blesch; Paul Lu
Journal:  J Vis Exp       Date:  2014-10-07       Impact factor: 1.355

7.  Soluble TNFα Signaling within the Spinal Cord Contributes to the Development of Autonomic Dysreflexia and Ensuing Vascular and Immune Dysfunction after Spinal Cord Injury.

Authors:  Eugene Mironets; Patrick Osei-Owusu; Valerie Bracchi-Ricard; Roman Fischer; Elizabeth A Owens; Jerome Ricard; Di Wu; Tatiana Saltos; Eileen Collyer; Shaoping Hou; John R Bethea; Veronica J Tom
Journal:  J Neurosci       Date:  2018-04-02       Impact factor: 6.167

8.  Attenuating Neurogenic Sympathetic Hyperreflexia Robustly Improves Antibacterial Immunity After Chronic Spinal Cord Injury.

Authors:  Eugene Mironets; Roman Fischer; Valerie Bracchi-Ricard; Tatiana M Saltos; Thomas S Truglio; Micaela L O'Reilly; Kathryn A Swanson; John R Bethea; Veronica J Tom
Journal:  J Neurosci       Date:  2019-11-21       Impact factor: 6.167

9.  Grafting Embryonic Raphe Neurons Reestablishes Serotonergic Regulation of Sympathetic Activity to Improve Cardiovascular Function after Spinal Cord Injury.

Authors:  Shaoping Hou; Tatiana M Saltos; Eugene Mironets; Cameron T Trueblood; Theresa M Connors; Veronica J Tom
Journal:  J Neurosci       Date:  2020-01-02       Impact factor: 6.167

10.  Cell transplantation and clinical reality: Kuwait experience in persons with spinal cord injury.

Authors:  S Al Kandari; L Prasad; M Al Kandari; U Ramachandran; A Krassioukov
Journal:  Spinal Cord       Date:  2018-02-22       Impact factor: 2.772
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.