S Al Kandari1, L Prasad2, M Al Kandari2, U Ramachandran2, A Krassioukov3. 1. Physical Medicine and Rehabilitation Hospital, Ministry of Health, Andalous, Kuwait. kandari77@hotmail.com. 2. Physical Medicine and Rehabilitation Hospital, Ministry of Health, Andalous, Kuwait. 3. ICORD, Department of Medicine, University of British Columbia, and GF Strong Rehabilitation Centre, Vancouver Costal Health, Vancouver, BC, Canada. krassioukov@icord.org.
Abstract
STUDY DESIGN: Retrospective observational. OBJECTIVES: To compare objective (neurological examination) and subjective (patients perception) recovery in patients with spinal cord injury (SCI) who chose to undergo cell transplantation therapies (CTT) outside of clinical trials abroad. SETTING: Physical Medicine and Rehabilitation Hospital, Kuwait. METHODS: Nine patients with SCI who had undergone CTT outside Kuwait were identified and their neurological pre-transplantation evaluation according the International Standards for Neurological Classification of SCI (ISNCSCI) was collected from hospital records. Post transplantation ISNCSCI examination was conducted during follow-up visits and scores were completed between pre and post CTT. In addition to the ISNCSCI evaluation, change in disability status, and patient's perception of improvement after stem cell transplantation were examined. RESULTS: Overall, 8 males and 1 female with chronic SCI underwent CTT (42 ± 38.2 months post SCI) in various centers (China, Egypt, Germany, India, and Iran). On follow-up post CTT assessment (89.2 ± 36 months post SCI), 55.5% of individuals reported perceived improvement as follows: increased deep tissue sensation below the injury (100%) or increase in bladder sensation (11.1%). Objective examination after CTT revealed that none of the examined individuals demonstrated improvement in their motor scores or neurological level of SCI. CONCLUSION: We were not able to objectively document clinically useful improvements in sensorimotor, autonomic, or functional status in individuals after CTT.
STUDY DESIGN: Retrospective observational. OBJECTIVES: To compare objective (neurological examination) and subjective (patients perception) recovery in patients with spinal cord injury (SCI) who chose to undergo cell transplantation therapies (CTT) outside of clinical trials abroad. SETTING: Physical Medicine and Rehabilitation Hospital, Kuwait. METHODS: Nine patients with SCI who had undergone CTT outside Kuwait were identified and their neurological pre-transplantation evaluation according the International Standards for Neurological Classification of SCI (ISNCSCI) was collected from hospital records. Post transplantation ISNCSCI examination was conducted during follow-up visits and scores were completed between pre and post CTT. In addition to the ISNCSCI evaluation, change in disability status, and patient's perception of improvement after stem cell transplantation were examined. RESULTS: Overall, 8 males and 1 female with chronic SCI underwent CTT (42 ± 38.2 months post SCI) in various centers (China, Egypt, Germany, India, and Iran). On follow-up post CTT assessment (89.2 ± 36 months post SCI), 55.5% of individuals reported perceived improvement as follows: increased deep tissue sensation below the injury (100%) or increase in bladder sensation (11.1%). Objective examination after CTT revealed that none of the examined individuals demonstrated improvement in their motor scores or neurological level of SCI. CONCLUSION: We were not able to objectively document clinically useful improvements in sensorimotor, autonomic, or functional status in individuals after CTT.
Authors: John W McDonald; Daniel Becker; Cristina L Sadowsky; Thomas E Conturo; Linda M Schultz Journal: J Neurosurg Date: 2002-10 Impact factor: 5.115
Authors: D Lammertse; M H Tuszynski; J D Steeves; A Curt; J W Fawcett; C Rask; J F Ditunno; M G Fehlings; J D Guest; P H Ellaway; N Kleitman; A R Blight; B H Dobkin; R Grossman; H Katoh; A Privat; M Kalichman Journal: Spinal Cord Date: 2006-12-19 Impact factor: 2.772
Authors: Qilin Cao; Xiao-Ming Xu; William H Devries; Gaby U Enzmann; Peipei Ping; Pantelis Tsoulfas; Patrick M Wood; Mary Bartlett Bunge; Scott R Whittemore Journal: J Neurosci Date: 2005-07-27 Impact factor: 6.167
Authors: Wolfram Tetzlaff; Elena B Okon; Soheila Karimi-Abdolrezaee; Caitlin E Hill; Joseph S Sparling; Jason R Plemel; Ward T Plunet; Eve C Tsai; Darryl Baptiste; Laura J Smithson; Michael D Kawaja; Michael G Fehlings; Brian K Kwon Journal: J Neurotrauma Date: 2010-04-20 Impact factor: 5.269
Authors: Allan D Levi; David O Okonkwo; Paul Park; Arthur L Jenkins; Shekar N Kurpad; Ann M Parr; Aruna Ganju; Bizhan Aarabi; Dong Kim; Steven Casha; Michael G Fehlings; James S Harrop; Kim D Anderson; Allyson Gage; Jane Hsieh; Stephen Huhn; Armin Curt; Raphael Guzman Journal: Neurosurgery Date: 2018-04-01 Impact factor: 4.654
Authors: J D Steeves; J K Kramer; J W Fawcett; J Cragg; D P Lammertse; A R Blight; R J Marino; J F Ditunno; W P Coleman; F H Geisler; J Guest; L Jones; S Burns; M Schubert; H J A van Hedel; A Curt Journal: Spinal Cord Date: 2010-08-17 Impact factor: 2.772
Authors: Jun Yan; Leyan Xu; Annie M Welsh; Glen Hatfield; Thomas Hazel; Karl Johe; Vassilis E Koliatsos Journal: PLoS Med Date: 2007-02 Impact factor: 11.069