Literature DB >> 24150415

Delivery materials for siRNA therapeutics.

Rosemary Kanasty1, Joseph Robert Dorkin, Arturo Vegas, Daniel Anderson.   

Abstract

RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short interfering RNA (siRNA) to the site of action in the cells of target tissues. This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the most effective and clinically advanced classes of siRNA delivery systems, including lipid nanoparticles and siRNA conjugates, are designed to surmount these challenges. The systems that we discuss are diverse in their approaches to the delivery problem, and provide valuable insight to guide the design of future siRNA delivery materials.

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Year:  2013        PMID： 24150415     DOI： 10.1038/nmat3765

Source DB:  PubMed          Journal:  Nat Mater        ISSN： 1476-1122            Impact factor:   43.841


  107 in total

Review 1.  Challenges in the pharmaceutical development of lipid-based short interfering ribonucleic acid therapeutics.

Authors:  Marian E Gindy; Anthony M Leone; James J Cunningham
Journal:  Expert Opin Drug Deliv       Date:  2012-02       Impact factor: 6.648

2.  Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.

Authors:  R P Goodman; I A T Schaap; C F Tardin; C M Erben; R M Berry; C F Schmidt; A J Turberfield
Journal:  Science       Date:  2005-12-09       Impact factor: 47.728

3.  Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo.

Authors:  So C Wong; Jason J Klein; Holly L Hamilton; Qili Chu; Christina L Frey; Vladimir S Trubetskoy; Julia Hegge; Darren Wakefield; David B Rozema; David L Lewis
Journal:  Nucleic Acid Ther       Date:  2012-12       Impact factor: 5.486

4.  pH-triggered nanoparticle mediated delivery of siRNA to liver cells in vitro and in vivo.

Authors:  Soumia Kolli; Suet-Ping Wong; Richard Harbottle; Brian Johnston; Maya Thanou; Andrew D Miller
Journal:  Bioconjug Chem       Date:  2013-03-07       Impact factor: 4.774

5.  Development of a nonviral gene delivery vehicle for systemic application.

Authors:  Suzie Hwang Pun; Mark E Davis
Journal:  Bioconjug Chem       Date:  2002 May-Jun       Impact factor: 4.774

6.  Effects of structure of beta-cyclodextrin-containing polymers on gene delivery.

Authors:  S J Hwang; N C Bellocq; M E Davis
Journal:  Bioconjug Chem       Date:  2001 Mar-Apr       Impact factor: 4.774

7.  New class of polymers for the delivery of macromolecular therapeutics.

Authors:  H Gonzalez; S J Hwang; M E Davis
Journal:  Bioconjug Chem       Date:  1999 Nov-Dec       Impact factor: 4.774

8.  Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

Authors:  Jürgen Soutschek; Akin Akinc; Birgit Bramlage; Klaus Charisse; Rainer Constien; Mary Donoghue; Sayda Elbashir; Anke Geick; Philipp Hadwiger; Jens Harborth; Matthias John; Venkitasamy Kesavan; Gary Lavine; Rajendra K Pandey; Timothy Racie; Kallanthottathil G Rajeev; Ingo Röhl; Ivanka Toudjarska; Gang Wang; Silvio Wuschko; David Bumcrot; Victor Koteliansky; Stefan Limmer; Muthiah Manoharan; Hans-Peter Vornlocher
Journal:  Nature       Date:  2004-11-11       Impact factor: 49.962

9.  Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface.

Authors:  Anna Salvati; Andrzej S Pitek; Marco P Monopoli; Kanlaya Prapainop; Francesca Baldelli Bombelli; Delyan R Hristov; Philip M Kelly; Christoffer Åberg; Eugene Mahon; Kenneth A Dawson
Journal:  Nat Nanotechnol       Date:  2013-01-20       Impact factor: 39.213

10.  A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo.

Authors:  Yusuke Sato; Hiroto Hatakeyama; Yu Sakurai; Mamoru Hyodo; Hidetaka Akita; Hideyoshi Harashima
Journal:  J Control Release       Date:  2012-09-20       Impact factor: 9.776
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  448 in total

1.  Comparison of thermally actuated retro-diels-alder release groups for nanoparticle based nucleic acid delivery.

Authors:  Mohammad Abu-Laban; Raju R Kumal; Jonathan Casey; Jeff Becca; Daniel LaMaster; Carlos N Pacheco; Dan G Sykes; Lasse Jensen; Louis H Haber; Daniel J Hayes
Journal:  J Colloid Interface Sci       Date:  2018-04-24       Impact factor: 8.128

2.  In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.

Authors:  James E Dahlman; Carmen Barnes; Omar Khan; Aude Thiriot; Siddharth Jhunjunwala; Taylor E Shaw; Yiping Xing; Hendrik B Sager; Gaurav Sahay; Lauren Speciner; Andrew Bader; Roman L Bogorad; Hao Yin; Tim Racie; Yizhou Dong; Shan Jiang; Danielle Seedorf; Apeksha Dave; Kamaljeet S Sandu; Matthew J Webber; Tatiana Novobrantseva; Vera M Ruda; Abigail K R Lytton-Jean; Christopher G Levins; Brian Kalish; Dayna K Mudge; Mario Perez; Ludmila Abezgauz; Partha Dutta; Lynelle Smith; Klaus Charisse; Mark W Kieran; Kevin Fitzgerald; Matthias Nahrendorf; Dganit Danino; Rubin M Tuder; Ulrich H von Andrian; Akin Akinc; Avi Schroeder; Dipak Panigrahy; Victor Kotelianski; Robert Langer; Daniel G Anderson
Journal:  Nat Nanotechnol       Date:  2014-05-11       Impact factor: 39.213

3.  Preparation of novel curdlan nanoparticles for intracellular siRNA delivery.

Authors:  Jingfen Han; Jia Cai; Wuyinga Borjihan; Tsogzolmaa Ganbold; Tariq M Rana; Huricha Baigude
Journal:  Carbohydr Polym       Date:  2014-10-05       Impact factor: 9.381

Review 4.  Designer lipids for drug delivery: from heads to tails.

Authors:  Aditya G Kohli; Paul H Kierstead; Vincent J Venditto; Colin L Walsh; Francis C Szoka
Journal:  J Control Release       Date:  2014-05-06       Impact factor: 9.776

5.  A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika.

Authors:  Jesse H Erasmus; Amit P Khandhar; Jeff Guderian; Brian Granger; Jacob Archer; Michelle Archer; Emily Gage; Jasmine Fuerte-Stone; Elise Larson; Susan Lin; Ryan Kramer; Rhea N Coler; Christopher B Fox; Dan T Stinchcomb; Steven G Reed; Neal Van Hoeven
Journal:  Mol Ther       Date:  2018-08-02       Impact factor: 11.454

Review 6.  Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives.

Authors:  Wolfgang Poller; Stefanie Dimmeler; Stephane Heymans; Tanja Zeller; Jan Haas; Mahir Karakas; David-Manuel Leistner; Philipp Jakob; Shinichi Nakagawa; Stefan Blankenberg; Stefan Engelhardt; Thomas Thum; Christian Weber; Benjamin Meder; Roger Hajjar; Ulf Landmesser
Journal:  Eur Heart J       Date:  2018-08-01       Impact factor: 29.983

7.  Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs.

Authors:  James C Kaczmarek; Asha K Patel; Kevin J Kauffman; Owen S Fenton; Matthew J Webber; Michael W Heartlein; Frank DeRosa; Daniel G Anderson
Journal:  Angew Chem Int Ed Engl       Date:  2016-09-30       Impact factor: 15.336

Review 8.  Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance.

Authors:  David F Pinelli; Mandy L Ford
Journal:  Immunotherapy       Date:  2015       Impact factor: 4.196

Review 9.  Engineering better immunotherapies via RNA interference.

Authors:  Mouldy Sioud
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

10.  Degradable poly(ethylene glycol) (PEG)-based hydrogels for spatiotemporal control of siRNA/nanoparticle delivery.

Authors:  Yuchen Wang; Sue Zhang; Danielle S W Benoit
Journal:  J Control Release       Date:  2018-08-03       Impact factor: 9.776
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