Literature DB >> 24145930

Middle East respiratory syndrome novel corona MERS-CoV infection. Epidemiology and outcome update.

Jaffar A Al-Tawfiq1, Abdullah Assiri, Ziad A Memish.   

Abstract

Middle East respiratory syndrome coronavirus MERS-CoV is a newly emerging respiratory virus with a high case fatality rate among identified cases. The virus is thought to cause a severe disease in patients with underlying comorbidities. The identification of asymptomatic patients and mild cases among family and healthcare worker contacts of confirmed cases indicates a wider spectrum of clinical manifestation of the disease. The majority of patients presented with fever 98%, fever with cough 83%, and shortness of breath 72%. Radiographic manifestations range from unilateral infiltrate 43%, to increased bronchovascular markings 17%, and diffuse reticulonodular pattern 4%. Our understanding of the epidemiology and clinical presentation of the disease is increasing overtime. It is still not known what the source of the virus is and what the best treatment modality should be.

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Year:  2013        PMID: 24145930

Source DB:  PubMed          Journal:  Saudi Med J        ISSN: 0379-5284            Impact factor:   1.484


  27 in total

1.  Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection.

Authors:  Kirsten A Kulcsar; Christopher M Coleman; Sarah E Beck; Matthew B Frieman
Journal:  JCI Insight       Date:  2019-10-17

2.  Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay.

Authors:  Mizuki Yamamoto; Shutoku Matsuyama; Xiao Li; Makoto Takeda; Yasushi Kawaguchi; Jun-Ichiro Inoue; Zene Matsuda
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

Review 3.  Animal models of Middle East respiratory syndrome coronavirus infection.

Authors:  Neeltje van Doremalen; Vincent J Munster
Journal:  Antiviral Res       Date:  2015-07-17       Impact factor: 5.970

Review 4.  Middle East respiratory syndrome coronavirus: epidemiology and disease control measures.

Authors:  Jaffar A Al-Tawfiq; Ziad A Memish
Journal:  Infect Drug Resist       Date:  2014-11-03       Impact factor: 4.003

Review 5.  Middle East respiratory syndrome: obstacles and prospects for vaccine development.

Authors:  Amy B Papaneri; Reed F Johnson; Jiro Wada; Laura Bollinger; Peter B Jahrling; Jens H Kuhn
Journal:  Expert Rev Vaccines       Date:  2015-04-11       Impact factor: 5.217

6.  Outbreak of Middle East Respiratory Syndrome at Tertiary Care Hospital, Jeddah, Saudi Arabia, 2014.

Authors:  Deborah L Hastings; Jerome I Tokars; Inas Zakaria A M Abdel Aziz; Khulud Z Alkhaldi; Areej T Bensadek; Basem M Alraddadi; Hani Jokhdar; John A Jernigan; Mohammed A Garout; Sara M Tomczyk; Ikwo K Oboho; Andrew I Geller; Nimalan Arinaminpathy; David L Swerdlow; Tariq A Madani
Journal:  Emerg Infect Dis       Date:  2016-05       Impact factor: 6.883

7.  Development of Dual TaqMan Based One-Step rRT-PCR Assay Panel for Rapid and Accurate Diagnostic Test of MERS-CoV: A Novel Human Coronavirus, Ahead of Hajj Pilgrimage.

Authors:  Mohammad Sadegh Hashemzadeh; Rahimeh Rasouli; Bentolhoda Zahraei; Morteza Izadi; Mahdi Tat; Seyed Hassan Saadat; Mohammad Najarasl; Behzad Khansari Nejad; Ruhollah Dorostkar
Journal:  Iran Red Crescent Med J       Date:  2016-06-21       Impact factor: 0.611

8.  Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome corona virus.

Authors:  Fahad M Al-Hameed
Journal:  Saudi Med J       Date:  2017-02       Impact factor: 1.484

9.  First Confirmed Case of Middle East Respiratory Syndrome Coronavirus Infection in the Kingdom of Bahrain: In a Saudi Gentleman after Cardiac Bypass Surgery.

Authors:  Nahed Seddiq; Manaf Al-Qahtani; Jaffar A Al-Tawfiq; Nazar Bukamal
Journal:  Case Rep Infect Dis       Date:  2017-08-28

10.  Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study.

Authors:  Ziad A Memish; Matthew Cotten; Simon J Watson; Paul Kellam; Alimuddin Zumla; Rafat F Alhakeem; Abdullah Assiri; Abdullah A Al Rabeeah; Jaffar A Al-Tawfiq
Journal:  Int J Infect Dis       Date:  2014-03-31       Impact factor: 3.623

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