AIM: Recent genome-wide association scans (GWAS) and replication studies have expanded the list of validated type 2 diabetes (T2DM) susceptibility loci. We replicated T2DM association of 19 SNPs from 15 candidate loci in Lebanese Arabs. METHODS: Case-control association study, comprising 995 T2DM patients and 1076 control participants. We genotyped by the allelic discrimination method 19 SNPs in/near ADAM30, NOTCH2, THADA, TMEFF2, COL8A1, ADAMTS9-AS2, WFS1, JAZF1, SLC30A8, KCNQ1, LOC387761, ALX4, TSPAN8, FTO, and HNF1. RESULTS: Allele frequencies of the tested SNPs were comparable with those of Caucasians. COL8A1 rs792837 (P=2.9 × 10(-9)), KCNQ1 rs2237892 (P=1.8 × 10(-18)) and rs2237895 (P=0.002), ALX4 rs729287 (Pc=7.5 × 10(-5)), and HNF1 rs4430796 (P=0.003) were significantly associated with T2DM, with similar effect sizes to those of Europeans. While FTO rs8050136 and rs17817449, ADAMTS9 rs4607103, and WFS1 rs10010131 were initially associated with T2DM, this was lost upon multiple testing correction. The remaining variants were not associated with T2DM, possibly resulting from insufficient power to detect smaller allele effects. CONCLUSION: In addition to previous findings on the association of IGF2BP2, CDKAL1, TCF7L2 variants with T2DM among Lebanese, here we extend these by validating the association of five additional loci with T2DM in Lebanese Arabs.
AIM: Recent genome-wide association scans (GWAS) and replication studies have expanded the list of validated type 2 diabetes (T2DM) susceptibility loci. We replicated T2DM association of 19 SNPs from 15 candidate loci in Lebanese Arabs. METHODS: Case-control association study, comprising 995 T2DM patients and 1076 control participants. We genotyped by the allelic discrimination method 19 SNPs in/near ADAM30, NOTCH2, THADA, TMEFF2, COL8A1, ADAMTS9-AS2, WFS1, JAZF1, SLC30A8, KCNQ1, LOC387761, ALX4, TSPAN8, FTO, and HNF1. RESULTS: Allele frequencies of the tested SNPs were comparable with those of Caucasians. COL8A1rs792837 (P=2.9 × 10(-9)), KCNQ1rs2237892 (P=1.8 × 10(-18)) and rs2237895 (P=0.002), ALX4rs729287 (Pc=7.5 × 10(-5)), and HNF1rs4430796 (P=0.003) were significantly associated with T2DM, with similar effect sizes to those of Europeans. While FTOrs8050136 and rs17817449, ADAMTS9rs4607103, and WFS1rs10010131 were initially associated with T2DM, this was lost upon multiple testing correction. The remaining variants were not associated with T2DM, possibly resulting from insufficient power to detect smaller allele effects. CONCLUSION: In addition to previous findings on the association of IGF2BP2, CDKAL1, TCF7L2 variants with T2DM among Lebanese, here we extend these by validating the association of five additional loci with T2DM in Lebanese Arabs.
Authors: Ping Rao; Yong Zhou; Si-Qi Ge; An-Xin Wang; Xin-Wei Yu; Mohamed Ali Alzain; Andrea Katherine Veronica; Jing Qiu; Man-Shu Song; Jie Zhang; Hao Wang; Hong-Hong Fang; Qing Gao; You-Xin Wang; Wei Wang Journal: Int J Environ Res Public Health Date: 2016-08-30 Impact factor: 3.390
Authors: Sarah L O'Beirne; Jacqueline Salit; Juan L Rodriguez-Flores; Michelle R Staudt; Charbel Abi Khalil; Khalid A Fakhro; Amal Robay; Monica D Ramstetter; Iman K Al-Azwani; Joel A Malek; Mahmoud Zirie; Amin Jayyousi; Ramin Badii; Ajayeb Al-Nabet Al-Marri; Maria J Chiuchiolo; Alya Al-Shakaki; Omar Chidiac; Maey Gharbiah; Abdulbari Bener; Dora Stadler; Neil R Hackett; Jason G Mezey; Ronald G Crystal Journal: PLoS One Date: 2016-07-06 Impact factor: 3.240
Authors: Michella Ghassibe-Sabbagh; Marc Haber; Angelique K Salloum; Yasser Al-Sarraj; Yasmine Akle; Kamal Hirbli; Jihane Romanos; Francis Mouzaya; Dominique Gauguier; Daniel E Platt; Hatem El-Shanti; Pierre A Zalloua Journal: Sci Rep Date: 2014-12-08 Impact factor: 4.379