Christopher S Melhus1, Justin K Mikell2, Steven J Frank3, Firas Mourtada4, Mark J Rivard5. 1. Department of Radiation Oncology, Tufts University School of Medicine, Boston, MA. 2. Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX. 3. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. 4. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Radiation Oncology, Christiana Care Hospital, Newark, DE. 5. Department of Radiation Oncology, Tufts University School of Medicine, Boston, MA. Electronic address: mark.j.rivard@gmail.com.
Abstract
PURPOSE: The aim of this study was to analyze the dosimetric influence of conventional spacers and a cobalt chloride complex contrast (C4) agent, a novel marker for MRI that can also serve as a seed spacer, adjacent to (103)Pd, (125)I, and (131)Cs sources for permanent prostate brachytherapy. METHODS AND MATERIALS: Monte Carlo methods for radiation transport were used to estimate the dosimetric influence of brachytherapy end-weld thicknesses and spacers near the three sources. Single-source assessments and volumetric conditions simulating prior patient treatments were computed. Volume-dose distributions were imported to a treatment planning system for dose-volume histogram analyses. RESULTS: Single-source assessment revealed that brachytherapy spacers primarily attenuated the dose distribution along the source long axis. The magnitude of the attenuation at 1 cm on the long axis ranged from -10% to -5% for conventional spacers and approximately -2% for C4 spacers, with the largest attenuation for (103)Pd. Spacer perturbation of dose distributions was less than manufacturing tolerances for brachytherapy sources as gleaned by an analysis of end-weld thicknesses. Volumetric Monte Carlo assessment demonstrated that TG-43 techniques overestimated calculated doses by approximately 2%. Specific dose-volume histogram metrics for prostate implants were not perturbed by inclusion of conventional or C4 spacers in clinical models. CONCLUSIONS: Dosimetric perturbations of single-seed dose distributions by brachytherapy spacers exceeded 10% along the source long axes adjacent to the spacers. However, no dosimetric impact on volumetric parameters was noted for brachytherapy spacers adjacent to (103)Pd, (125)I, or (131)Cs sources in the context of permanent prostate brachytherapy implants.
PURPOSE: The aim of this study was to analyze the dosimetric influence of conventional spacers and a cobalt chloride complex contrast (C4) agent, a novel marker for MRI that can also serve as a seed spacer, adjacent to (103)Pd, (125)I, and (131)Cs sources for permanent prostate brachytherapy. METHODS AND MATERIALS: Monte Carlo methods for radiation transport were used to estimate the dosimetric influence of brachytherapy end-weld thicknesses and spacers near the three sources. Single-source assessments and volumetric conditions simulating prior patient treatments were computed. Volume-dose distributions were imported to a treatment planning system for dose-volume histogram analyses. RESULTS: Single-source assessment revealed that brachytherapy spacers primarily attenuated the dose distribution along the source long axis. The magnitude of the attenuation at 1 cm on the long axis ranged from -10% to -5% for conventional spacers and approximately -2% for C4 spacers, with the largest attenuation for (103)Pd. Spacer perturbation of dose distributions was less than manufacturing tolerances for brachytherapy sources as gleaned by an analysis of end-weld thicknesses. Volumetric Monte Carlo assessment demonstrated that TG-43 techniques overestimated calculated doses by approximately 2%. Specific dose-volume histogram metrics for prostate implants were not perturbed by inclusion of conventional or C4 spacers in clinical models. CONCLUSIONS: Dosimetric perturbations of single-seed dose distributions by brachytherapy spacers exceeded 10% along the source long axes adjacent to the spacers. However, no dosimetric impact on volumetric parameters was noted for brachytherapy spacers adjacent to (103)Pd, (125)I, or (131)Cs sources in the context of permanent prostate brachytherapy implants.
Authors: Jingfei Ma; Marinus A Moerland; Aradhana M Venkatesan; Tharakeswara K Bathala; Rajat J Kudchadker; Kristy K Brock; Steven J Frank Journal: Brachytherapy Date: 2017-01-04 Impact factor: 2.362
Authors: Tze Yee Lim; Rajat J Kudchadker; Jihong Wang; R Jason Stafford; Christopher MacLellan; Arvind Rao; Geoffrey S Ibbott; Steven J Frank Journal: Med Phys Date: 2016-07 Impact factor: 4.071
Authors: Tze Yee Lim; R Jason Stafford; Rajat J Kudchadker; Madhuri Sankaranarayanapillai; Geoffrey Ibbott; Arvind Rao; Karen S Martirosyan; Steven J Frank Journal: Phys Med Biol Date: 2014-04-28 Impact factor: 3.609