Literature DB >> 24139026

ADAM10 prodomain mutations cause late-onset Alzheimer's disease: not just the latest FAD.

Robert Vassar1.   

Abstract

In this issue of Neuron, Suh et al. (2013) describe two rare ADAM10 prodomain mutations that cause late-onset Alzheimer's disease by impairing prodomain chaperone function, attenuating α-secretase activity, and reducing adult hippocampal neurogenesis. These results support both ADAM10 as a therapeutic target and the amyloid hypothesis of Alzheimer's disease.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24139026      PMCID： PMC4090694          DOI： 10.1016/j.neuron.2013.09.031

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  15 in total

1.  Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.

Authors:  A Anders; S Gilbert; W Garten; R Postina; F Fahrenholz
Journal:  FASEB J       Date:  2001-08       Impact factor: 5.191

2.  Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

Authors:  Isabelle Caillé; Bernadette Allinquant; Edmond Dupont; Colette Bouillot; Andreas Langer; Ulrike Müller; Alain Prochiantz
Journal:  Development       Date:  2004-04-08       Impact factor: 6.868

3.  ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function.

Authors:  Jaehong Suh; Se Hoon Choi; Donna M Romano; Moira A Gannon; Andrea N Lesinski; Doo Yeon Kim; Rudolph E Tanzi
Journal:  Neuron       Date:  2013-09-19       Impact factor: 17.173

Review 4.  The secretases: enzymes with therapeutic potential in Alzheimer disease.

Authors:  Bart De Strooper; Robert Vassar; Todd Golde
Journal:  Nat Rev Neurol       Date:  2010-02       Impact factor: 42.937

5.  Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

Authors:  Minji Kim; Jaehong Suh; Donna Romano; Mimy H Truong; Kristina Mullin; Basavaraj Hooli; David Norton; Giuseppina Tesco; Kathy Elliott; Steven L Wagner; Robert D Moir; K David Becker; Rudolph E Tanzi
Journal:  Hum Mol Genet       Date:  2009-07-15       Impact factor: 6.150

6.  Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

Authors:  M P Mattson; B Cheng; A R Culwell; F S Esch; I Lieberburg; R E Rydel
Journal:  Neuron       Date:  1993-02       Impact factor: 17.173

7.  A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model.

Authors:  Rolf Postina; Anja Schroeder; Ilse Dewachter; Juergen Bohl; Ulrich Schmitt; Elzbieta Kojro; Claudia Prinzen; Kristina Endres; Christoph Hiemke; Manfred Blessing; Pascaline Flamez; Antoine Dequenne; Emile Godaux; Fred van Leuven; Falk Fahrenholz
Journal:  J Clin Invest       Date:  2004-05       Impact factor: 14.808

Review 8.  The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

Authors:  John Hardy; Dennis J Selkoe
Journal:  Science       Date:  2002-07-19       Impact factor: 47.728

9.  The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

Authors:  Dieter Hartmann; Bart de Strooper; Lutgarde Serneels; Katleen Craessaerts; An Herreman; Wim Annaert; Lieve Umans; Torben Lübke; Anna Lena Illert; Kurt von Figura; Paul Saftig
Journal:  Hum Mol Genet       Date:  2002-10-01       Impact factor: 6.150

10.  The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

Authors:  Sabine Ring; Sascha W Weyer; Susanne B Kilian; Elaine Waldron; Claus U Pietrzik; Mikhail A Filippov; Jochen Herms; Christian Buchholz; Christopher B Eckman; Martin Korte; David P Wolfer; Ulrike C Müller
Journal:  J Neurosci       Date:  2007-07-18       Impact factor: 6.167
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  12 in total

Review 1.  The role of cholesterol metabolism in Alzheimer's disease.

Authors:  Jia-Hao Sun; Jin-Tai Yu; Lan Tan
Journal:  Mol Neurobiol       Date:  2014-05-18       Impact factor: 5.590

2.  Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:  Brian W Kunkle; Benjamin Grenier-Boley; Rebecca Sims; Joshua C Bis; Vincent Damotte; Adam C Naj; Anne Boland; Maria Vronskaya; Sven J van der Lee; Alexandre Amlie-Wolf; Céline Bellenguez; Aura Frizatti; Vincent Chouraki; Eden R Martin; Kristel Sleegers; Nandini Badarinarayan; Johanna Jakobsdottir; Kara L Hamilton-Nelson; Sonia Moreno-Grau; Robert Olaso; Rachel Raybould; Yuning Chen; Amanda B Kuzma; Mikko Hiltunen; Taniesha Morgan; Shahzad Ahmad; Badri N Vardarajan; Jacques Epelbaum; Per Hoffmann; Merce Boada; Gary W Beecham; Jean-Guillaume Garnier; Denise Harold; Annette L Fitzpatrick; Otto Valladares; Marie-Laure Moutet; Amy Gerrish; Albert V Smith; Liming Qu; Delphine Bacq; Nicola Denning; Xueqiu Jian; Yi Zhao; Maria Del Zompo; Nick C Fox; Seung-Hoan Choi; Ignacio Mateo; Joseph T Hughes; Hieab H Adams; John Malamon; Florentino Sanchez-Garcia; Yogen Patel; Jennifer A Brody; Beth A Dombroski; Maria Candida Deniz Naranjo; Makrina Daniilidou; Gudny Eiriksdottir; Shubhabrata Mukherjee; David Wallon; James Uphill; Thor Aspelund; Laura B Cantwell; Fabienne Garzia; Daniela Galimberti; Edith Hofer; Mariusz Butkiewicz; Bertrand Fin; Elio Scarpini; Chloe Sarnowski; Will S Bush; Stéphane Meslage; Johannes Kornhuber; Charles C White; Yuenjoo Song; Robert C Barber; Sebastiaan Engelborghs; Sabrina Sordon; Dina Voijnovic; Perrie M Adams; Rik Vandenberghe; Manuel Mayhaus; L Adrienne Cupples; Marilyn S Albert; Peter P De Deyn; Wei Gu; Jayanadra J Himali; Duane Beekly; Alessio Squassina; Annette M Hartmann; Adelina Orellana; Deborah Blacker; Eloy Rodriguez-Rodriguez; Simon Lovestone; Melissa E Garcia; Rachelle S Doody; Carmen Munoz-Fernadez; Rebecca Sussams; Honghuang Lin; Thomas J Fairchild; Yolanda A Benito; Clive Holmes; Hata Karamujić-Čomić; Matthew P Frosch; Hakan Thonberg; Wolfgang Maier; Gennady Roshchupkin; Bernardino Ghetti; Vilmantas Giedraitis; Amit Kawalia; Shuo Li; Ryan M Huebinger; Lena Kilander; Susanne Moebus; Isabel Hernández; M Ilyas Kamboh; RoseMarie Brundin; James Turton; Qiong Yang; Mindy J Katz; Letizia Concari; Jenny Lord; Alexa S Beiser; C Dirk Keene; Seppo Helisalmi; Iwona Kloszewska; Walter A Kukull; Anne Maria Koivisto; Aoibhinn Lynch; Lluís Tarraga; Eric B Larson; Annakaisa Haapasalo; Brian Lawlor; Thomas H Mosley; Richard B Lipton; Vincenzo Solfrizzi; Michael Gill; W T Longstreth; Thomas J Montine; Vincenza Frisardi; Monica Diez-Fairen; Fernando Rivadeneira; Ronald C Petersen; Vincent Deramecourt; Ignacio Alvarez; Francesca Salani; Antonio Ciaramella; Eric Boerwinkle; Eric M Reiman; Nathalie Fievet; Jerome I Rotter; Joan S Reisch; Olivier Hanon; Chiara Cupidi; A G Andre Uitterlinden; Donald R Royall; Carole Dufouil; Raffaele Giovanni Maletta; Itziar de Rojas; Mary Sano; Alexis Brice; Roberta Cecchetti; Peter St George-Hyslop; Karen Ritchie; Magda Tsolaki; Debby W Tsuang; Bruno Dubois; David Craig; Chuang-Kuo Wu; Hilkka Soininen; Despoina Avramidou; Roger L Albin; Laura Fratiglioni; Antonia Germanou; Liana G Apostolova; Lina Keller; Maria Koutroumani; 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Barry Reisberg; Robert Clarke; Christiane Reitz; A David Smith; John M Ringman; Donald Warden; Erik D Roberson; Gordon Wilcock; Ekaterina Rogaeva; Amalia Cecilia Bruni; Howard J Rosen; Maura Gallo; Roger N Rosenberg; Yoav Ben-Shlomo; Mark A Sager; Patrizia Mecocci; Andrew J Saykin; Pau Pastor; Michael L Cuccaro; Jeffery M Vance; Julie A Schneider; Lori S Schneider; Susan Slifer; William W Seeley; Amanda G Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Russell H Swerdlow; Mitchell Tang; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Linda J Van Eldik; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Kirk C Wilhelmsen; Jennifer Williamson; Thomas S Wingo; Randall L Woltjer; Clinton B Wright; Chang-En Yu; Lei Yu; Yasaman Saba; Alberto Pilotto; Maria J Bullido; Oliver Peters; Paul K Crane; David Bennett; Paola Bosco; Eliecer Coto; Virginia Boccardi; Phil L De Jager; Alberto Lleo; Nick Warner; Oscar L Lopez; Martin Ingelsson; Panagiotis Deloukas; Carlos Cruchaga; Caroline Graff; Rhian Gwilliam; Myriam Fornage; Alison M Goate; Pascual Sanchez-Juan; Patrick G Kehoe; Najaf Amin; Nilifur Ertekin-Taner; Claudine Berr; Stéphanie Debette; Seth Love; Lenore J Launer; Steven G Younkin; Jean-Francois Dartigues; Chris Corcoran; M Arfan Ikram; Dennis W Dickson; Gael Nicolas; Dominique Campion; JoAnn Tschanz; Helena Schmidt; Hakon Hakonarson; Jordi Clarimon; Ron Munger; Reinhold Schmidt; Lindsay A Farrer; Christine Van Broeckhoven; Michael C O'Donovan; Anita L DeStefano; Lesley Jones; Jonathan L Haines; Jean-Francois Deleuze; Michael J Owen; Vilmundur Gudnason; Richard Mayeux; Valentina Escott-Price; Bruce M Psaty; Alfredo Ramirez; Li-San Wang; Agustin Ruiz; Cornelia M van Duijn; Peter A Holmans; Sudha Seshadri; Julie Williams; Phillippe Amouyel; Gerard D Schellenberg; Jean-Charles Lambert; Margaret A Pericak-Vance
Journal:  Nat Genet       Date:  2019-02-28       Impact factor: 41.307

3.  SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation.

Authors:  C Saraceno; E Marcello; D Di Marino; B Borroni; S Claeysen; J Perroy; A Padovani; A Tramontano; F Gardoni; M Di Luca
Journal:  Cell Death Dis       Date:  2014-11-27       Impact factor: 8.469

4.  NeuroRDF: semantic integration of highly curated data to prioritize biomarker candidates in Alzheimer's disease.

Authors:  Anandhi Iyappan; Shweta Bagewadi Kawalia; Tamara Raschka; Martin Hofmann-Apitius; Philipp Senger
Journal:  J Biomed Semantics       Date:  2016-07-08

5.  Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production.

Authors:  Lingli Yan; Yuanyuan Deng; Jianmei Gao; Yuangui Liu; Fei Li; Jingshan Shi; Qihai Gong
Journal:  Front Pharmacol       Date:  2017-03-08       Impact factor: 5.810

6.  Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats.

Authors:  Caixia Yin; Yuanyuan Deng; Yuangui Liu; Jianmei Gao; Lingli Yan; Qihai Gong
Journal:  Front Pharmacol       Date:  2018-10-23       Impact factor: 5.810

7.  Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.

Authors:  Meng-Shan Tan; Yu-Xiang Yang; Wei Xu; Hui-Fu Wang; Lin Tan; Chuan-Tao Zuo; Qiang Dong; Lan Tan; John Suckling; Jin-Tai Yu
Journal:  Alzheimers Res Ther       Date:  2021-01-08       Impact factor: 6.982

8.  Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer's disease.

Authors:  Lanyu Zhang; Tiago C Silva; Juan I Young; Lissette Gomez; Michael A Schmidt; Kara L Hamilton-Nelson; Brian W Kunkle; Xi Chen; Eden R Martin; Lily Wang
Journal:  Nat Commun       Date:  2020-11-30       Impact factor: 14.919

Review 9.  Structural Studies Providing Insights into Production and Conformational Behavior of Amyloid-β Peptide Associated with Alzheimer's Disease Development.

Authors:  Anatoly S Urban; Konstantin V Pavlov; Anna V Kamynina; Ivan S Okhrimenko; Alexander S Arseniev; Eduard V Bocharov
Journal:  Molecules       Date:  2021-05-13       Impact factor: 4.411

Review 10.  Advances in Genetics and Epigenetic Alterations in Alzheimer's Disease: A Notion for Therapeutic Treatment.

Authors:  Rubén Rabaneda-Bueno; Beatriz Mena-Montes; Sara Torres-Castro; Norma Torres-Carrillo; Nora Magdalena Torres-Carrillo
Journal:  Genes (Basel)       Date:  2021-12-08       Impact factor: 4.096
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