BACKGROUND: No reliable clinical markers to diagnose early stage-disease and predict its prognosis have yet been found for squamous cell carcinoma of the head and neck (HNSCC). MATERIALS AND METHODS: In the present study, the metabolomic analysis of serum and tissue samples obtained from patients with HNSCC was performed using gas chromatography/mass spectrometry. RESULTS: In serum, levels of several metabolites related to the glycolytic pathway, such as glucose, were higher in patients with HNSCC, and the levels of several amino acids were lower. In contrast to sera, the levels of many metabolites related to the glycolytic pathway appeared to be lower in tumor tissues of HNSCC than in non-tumorous tissues, and the levels of several amino acids, such as valine, thyrosine, serine and methionine, were higher. CONCLUSION: Our results demonstrate that changes in metabolite patterns are useful in assessing the clinical characteristics of HNSCC, and will hopefully lead to the establishment of novel diagnostic tools.
BACKGROUND: No reliable clinical markers to diagnose early stage-disease and predict its prognosis have yet been found for squamous cell carcinoma of the head and neck (HNSCC). MATERIALS AND METHODS: In the present study, the metabolomic analysis of serum and tissue samples obtained from patients with HNSCC was performed using gas chromatography/mass spectrometry. RESULTS: In serum, levels of several metabolites related to the glycolytic pathway, such as glucose, were higher in patients with HNSCC, and the levels of several amino acids were lower. In contrast to sera, the levels of many metabolites related to the glycolytic pathway appeared to be lower in tumor tissues of HNSCC than in non-tumorous tissues, and the levels of several amino acids, such as valine, thyrosine, serine and methionine, were higher. CONCLUSION: Our results demonstrate that changes in metabolite patterns are useful in assessing the clinical characteristics of HNSCC, and will hopefully lead to the establishment of novel diagnostic tools.
Entities:
Keywords:
Metabolomics; amino acid; glycolytic pathway; head and neck cancer; serum; tissue
Authors: Ronald C Eldridge; Karan Uppal; D Neil Hayes; M Ryan Smith; Xin Hu; Zhaohui S Qin; Jonathan J Beitler; Andrew H Miller; Evanthia C Wommack; Kristin A Higgins; Dong M Shin; Bryan Ulrich; David C Qian; Nabil F Saba; Deborah W Bruner; Dean P Jones; Canhua Xiao Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-08-10 Impact factor: 4.254
Authors: R Alex Harbison; Rajeev Pandey; Michael Considine; Robert D Leone; Tracy Murray-Stewart; Rossin Erbe; Raj Mandal; Mark Burns; Robert A Casero; Tanguy Seiwert; Carole Fakhry; Drew Pardoll; Elana Fertig; Jonathan D Powell Journal: Cancer Res Commun Date: 2022-07-13