Rachel L Goldman1, Melanie Canterberry1, Jeffrey J Borckardt1,2, Alok Madan1, T Karl Byrne3, Mark S George1,3,4, Patrick M O'Neil1, Colleen A Hanlon1. 1. Department of Psychiatry and Behavioral Sciences, Charleston, South Carolina, USA. 2. Department of Anesthesiology and Perioperative Medicine, Charleston, South Carolina, USA. 3. Department of Surgery Department of Neurology and Radiology Medical University of South Carolina, Charleston, South Carolina, USA. 4. Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA.
Abstract
OBJECTIVE: While overall success rates of bariatric surgery are high, approximately 20% of patients either regain or never lose the expected amount of weight. The purpose of this study was to determine whether, after gastric-bypass surgery, the degree of weight loss can be differentiated based on the neural response to food cues. DESIGN AND METHODS: In this functional MRI study, 31 post-surgical patients viewed food and neutral images in two counterbalanced runs during which they were either instructed to "crave" or to "resist" craving. The neural response to food cues was assessed within and between runs for all participants, and further analyzed between more successful (n = 24) and less successful (n = 7) groups. More successful was defined by meeting 50% excess weight loss. RESULTS: Overall, instructions to "crave" elicited significant activity in the dorsomedial prefrontal cortex (PFC) whereas "resist" elicited significant activity in the dorsolateral PFC (DLPFC). Between groups there was no brain difference when instructed to "crave." The more successful participants however had significantly more activity in the DLPFC when instructed to "resist." CONCLUSIONS: These findings suggest that the ability to mobilize neural circuits involved in executive control post-gastric-bypass surgery may be a unique component of successful outcome post-surgery.
OBJECTIVE: While overall success rates of bariatric surgery are high, approximately 20% of patients either regain or never lose the expected amount of weight. The purpose of this study was to determine whether, after gastric-bypass surgery, the degree of weight loss can be differentiated based on the neural response to food cues. DESIGN AND METHODS: In this functional MRI study, 31 post-surgical patients viewed food and neutral images in two counterbalanced runs during which they were either instructed to "crave" or to "resist" craving. The neural response to food cues was assessed within and between runs for all participants, and further analyzed between more successful (n = 24) and less successful (n = 7) groups. More successful was defined by meeting 50% excess weight loss. RESULTS: Overall, instructions to "crave" elicited significant activity in the dorsomedial prefrontal cortex (PFC) whereas "resist" elicited significant activity in the dorsolateral PFC (DLPFC). Between groups there was no brain difference when instructed to "crave." The more successful participants however had significantly more activity in the DLPFC when instructed to "resist." CONCLUSIONS: These findings suggest that the ability to mobilize neural circuits involved in executive control post-gastric-bypass surgery may be a unique component of successful outcome post-surgery.
Authors: Hugh Myrick; Raymond F Anton; Xingbao Li; Scott Henderson; David Drobes; Konstantin Voronin; Mark S George Journal: Neuropsychopharmacology Date: 2004-02 Impact factor: 7.853
Authors: William D S Killgore; Ashley D Young; Lisa A Femia; Piotr Bogorodzki; Jadwiga Rogowska; Deborah A Yurgelun-Todd Journal: Neuroimage Date: 2003-08 Impact factor: 6.556
Authors: Nina Crowley; Alok Madan; Sharlene Wedin; Jennifer A Correll; Laura M Delustro; Jeffery J Borckardt; T Karl Byrne Journal: Eat Weight Disord Date: 2014-01-21 Impact factor: 4.652
Authors: D Val-Laillet; E Aarts; B Weber; M Ferrari; V Quaresima; L E Stoeckel; M Alonso-Alonso; M Audette; C H Malbert; E Stice Journal: Neuroimage Clin Date: 2015-03-24 Impact factor: 4.881