OBJECTIVE: To investigate the response of the brains of women to the ingestion of a meal. RESEARCH METHODS AND PROCEDURES: We used measures of regional cerebral blood flow (rCBF), a marker of neuronal activity, by positron emission tomography to describe the functional anatomy of satiation, i.e., the response to a liquid meal in the context of extreme hunger (36-hour fast) in 10 lean (BMI < or = 25 kg/m(2); 32 +/- 10 years old, 61 +/- 7 kg; mean +/- SD) and 12 obese (BMI > or = 35 kg/m(2); 30 +/- 7 years old, 110 +/- 14 kg) women. RESULTS: In lean and obese women, satiation produced significant increases in rCBF in the vicinity of the prefrontal cortex (p < 0.005). Satiation also produced significant decreases in rCBF in several regions including the thalamus, insular cortex, parahippocampal gyrus, temporal cortex, and cerebellum (in lean and obese women), and hypothalamus, cingulate, nucleus accumbens, and amygdala (in obese women only; all p < 0.005). Compared with lean women, obese women had significantly greater increases in rCBF in the ventral prefrontal cortex and had significantly greater decreases in the paralimbic areas and in areas of the frontal and temporal cortex. DISCUSSION: This study indicates that satiation elicits differential brain responses in obese and lean women. It also lends additional support to the hypothesis that the paralimbic areas participate in a central orexigenic network modulated by the prefrontal cortex through feedback loops.
OBJECTIVE: To investigate the response of the brains of women to the ingestion of a meal. RESEARCH METHODS AND PROCEDURES: We used measures of regional cerebral blood flow (rCBF), a marker of neuronal activity, by positron emission tomography to describe the functional anatomy of satiation, i.e., the response to a liquid meal in the context of extreme hunger (36-hour fast) in 10 lean (BMI < or = 25 kg/m(2); 32 +/- 10 years old, 61 +/- 7 kg; mean +/- SD) and 12 obese (BMI > or = 35 kg/m(2); 30 +/- 7 years old, 110 +/- 14 kg) women. RESULTS: In lean and obesewomen, satiation produced significant increases in rCBF in the vicinity of the prefrontal cortex (p < 0.005). Satiation also produced significant decreases in rCBF in several regions including the thalamus, insular cortex, parahippocampal gyrus, temporal cortex, and cerebellum (in lean and obesewomen), and hypothalamus, cingulate, nucleus accumbens, and amygdala (in obesewomen only; all p < 0.005). Compared with lean women, obesewomen had significantly greater increases in rCBF in the ventral prefrontal cortex and had significantly greater decreases in the paralimbic areas and in areas of the frontal and temporal cortex. DISCUSSION: This study indicates that satiation elicits differential brain responses in obese and lean women. It also lends additional support to the hypothesis that the paralimbic areas participate in a central orexigenic network modulated by the prefrontal cortex through feedback loops.
Authors: P Vinai; D Masante; S Cardetti; N Ferrato; P Vallaur; G Carpegna; S Sassaroli; G M Ruggiero Journal: Eat Weight Disord Date: 2009-12 Impact factor: 4.652
Authors: Terry L Davidson; Scott E Kanoski; Lindsey A Schier; Deborah J Clegg; Stephen C Benoit Journal: Curr Opin Pharmacol Date: 2007-11-26 Impact factor: 5.547
Authors: Kate Baicy; Edythe D London; John Monterosso; Ma-Li Wong; Tuncay Delibasi; Anil Sharma; Julio Licinio Journal: Proc Natl Acad Sci U S A Date: 2007-11-06 Impact factor: 11.205
Authors: Duc Son Nt Le; Nicola Pannacciulli; Kewei Chen; Arline D Salbe; Angelo Del Parigi; James O Hill; Rena R Wing; Eric M Reiman; Jonathan Krakoff Journal: Am J Clin Nutr Date: 2007-09 Impact factor: 7.045