Literature DB >> 24136244

Hyposmia: a possible biomarker of Parkinson's disease.

Qian Xiao1, Sheng Chen, Weidong Le.   

Abstract

Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson's disease (PD) that antedates the typical motor symptoms by several years. It occurs in ∼90% of early-stage cases of PD. In addition to the high prevalence, the occurrence of hyposmia may also predict a higher risk of PD. Investigations into hyposmia and its relationship with PD may help elucidate the underlying pathogenic mechanisms. This review provides an update of olfactory dysfunction in PD and its potential as a biomarker for this devastating disease.

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Year:  2013        PMID： 24136244      PMCID： PMC5562575          DOI： 10.1007/s12264-013-1390-3

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


  48 in total

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Journal:  J Chronic Dis       Date:  1975-10

2.  Microglial/macrophage cells in mammalian olfactory nerve fascicles.

Authors:  Laura J Smithson; Michael D Kawaja
Journal:  J Neurosci Res       Date:  2010-03       Impact factor: 4.164

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Journal:  N Engl J Med       Date:  1988-04-07       Impact factor: 91.245

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Authors:  Isabelle A Tourbier; Richard L Doty
Journal:  Chem Senses       Date:  2007-05-07       Impact factor: 3.160

Review 5.  The olfactory vector hypothesis of neurodegenerative disease: is it viable?

Authors:  Richard L Doty
Journal:  Ann Neurol       Date:  2008-01       Impact factor: 10.422

6.  Prevalence of smell loss in Parkinson's disease--a multicenter study.

Authors:  A Haehner; S Boesveldt; H W Berendse; A Mackay-Sim; J Fleischmann; P A Silburn; A N Johnston; G D Mellick; B Herting; H Reichmann; T Hummel
Journal:  Parkinsonism Relat Disord       Date:  2009-01-11       Impact factor: 4.891

7.  Diagnostic performance of clinical motor and non-motor tests of Parkinson disease: a matched case-control study.

Authors:  N I Bohnen; S A Studenski; G M Constantine; R Y Moore
Journal:  Eur J Neurol       Date:  2008-04-24       Impact factor: 6.089

8.  Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration.

Authors:  R L Doty; D A Deems; S Stellar
Journal:  Neurology       Date:  1988-08       Impact factor: 9.910

Review 9.  Neurodegenerative diseases: an overview of environmental risk factors.

Authors:  Rebecca C Brown; Alan H Lockwood; Babasaheb R Sonawane
Journal:  Environ Health Perspect       Date:  2005-09       Impact factor: 9.031

Review 10.  Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease.

Authors:  Leah R Hanson; William H Frey
Journal:  BMC Neurosci       Date:  2008-12-10       Impact factor: 3.288
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  19 in total

1.  A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.

Authors:  Brian P Dranka; Alison Gifford; Donna McAllister; Jacek Zielonka; Joy Joseph; Crystal L O'Hara; Cheryl L Stucky; Anumantha G Kanthasamy; Balaraman Kalyanaraman
Journal:  Neurosci Lett       Date:  2014-09-26       Impact factor: 3.046

2.  Reliability and validity of the Chinese version of the questionnaire of olfactory disorders (QOD) when used with patients having olfactory dysfunction.

Authors:  DaHai Yang; Jian Wang; DaoFeng Ni; JianFeng Liu; Xin Wang
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-01-02       Impact factor: 2.503

Review 3.  Transcription Factors: Potential Cell Death Markers in Parkinson's Disease.

Authors:  Ronglin Wang; Shaosong Yang; Tiejian Nie; Gang Zhu; Dayun Feng; Qian Yang
Journal:  Neurosci Bull       Date:  2017-08-08       Impact factor: 5.203

4.  Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program.

Authors:  Katrina Gwinn; Karen K David; Christine Swanson-Fischer; Roger Albin; Coryse St Hillaire-Clarke; Beth-Anne Sieber; Codrin Lungu; F DuBois Bowman; Roy N Alcalay; Debra Babcock; Ted M Dawson; Richard B Dewey; Tatiana Foroud; Dwight German; Xuemei Huang; Vlad Petyuk; Judith A Potashkin; Rachel Saunders-Pullman; Margaret Sutherland; David R Walt; Andrew B West; Jing Zhang; Alice Chen-Plotkin; Clemens R Scherzer; David E Vaillancourt; Liana S Rosenthal
Journal:  Biomark Med       Date:  2017-06-23       Impact factor: 2.851

5.  Spotlight on non-motor symptoms and Covid-19.

Authors:  Silvia Rota; Iro Boura; Yi-Min Wan; Claudia Lazcano-Ocampo; Mayela Rodriguez-Violante; Angelo Antonini; Kallol Ray Chaudhuri
Journal:  Int Rev Neurobiol       Date:  2022-07-09       Impact factor: 4.280

Review 6.  Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?

Authors:  Weidong Le; Jie Dong; Song Li; Amos D Korczyn
Journal:  Neurosci Bull       Date:  2017-09-02       Impact factor: 5.203

Review 7.  The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.

Authors:  Rebekah G Langston; Iakov N Rudenko; Mark R Cookson
Journal:  Biochem J       Date:  2016-02-01       Impact factor: 3.857

8.  Clinical Progression of Parkinson's Disease: Insights from the NINDS Common Data Elements.

Authors:  Mechelle M Lewis; Elias Harkins; Eun-Young Lee; Christy Stetter; Bethany Snyder; Tyler Corson; Guangwei Du; Lan Kong; Xuemei Huang
Journal:  J Parkinsons Dis       Date:  2020       Impact factor: 5.568

9.  Assessment of Olfactory Function in MAPT-Associated Neurodegenerative Disease Reveals Odor-Identification Irreproducibility as a Non-Disease-Specific, General Characteristic of Olfactory Dysfunction.

Authors:  Katerina Markopoulou; Bruce A Chase; Piotr Robowski; Audrey Strongosky; Ewa Narożańska; Emilia J Sitek; Mariusz Berdynski; Maria Barcikowska; Matt C Baker; Rosa Rademakers; Jarosław Sławek; Christine Klein; Katja Hückelheim; Meike Kasten; Zbigniew K Wszolek
Journal:  PLoS One       Date:  2016-11-17       Impact factor: 3.240

Review 10.  Odorants could elicit repair processes in melanized neuronal and skin cells.

Authors:  Barbara Pavan; Alessandro Dalpiaz
Journal:  Neural Regen Res       Date:  2017-09       Impact factor: 5.135
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