Literature DB >> 24135896

A photoactivatable drug-caged fluorophore conjugate allows direct quantification of intracellular drug transport.

Sarit S Agasti1, Ashley M Laughney1, Rainer H Kohler1, Ralph Weissleder1,2.   

Abstract

We report here a method that utilizes a photoactivatable drug-caged fluorophore conjugate to quantify intracellular drug trafficking processes at single cell resolution. Photoactivation is performed in labeled cellular compartments to visualize intracellular drug exchange under physiological conditions, without the need for washing, facilitating its translation into in vivo cancer models.

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Year:  2013        PMID： 24135896      PMCID： PMC3856557          DOI： 10.1039/c3cc46089d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


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