Literature DB >> 24134151

Fibroblast growth factor receptor 2: a therapeutic target in gastric cancer.

Liu Hong1, Yu Han, Jinqiang Liu, Lubi Brain.   

Abstract

Gastric cancer remains a leading cause of cancer-related death in the world. FGF receptor 2 (FGFR2) is preferentially amplified and overexpressed in the diffuse type of gastric cancer. This review evaluates the expression and function of FGFR2 in gastric cancer, and analyzes the use of its inhibitors for gastric cancer therapy. This review also discusses the limitations of FGFR2-based therapy, and envisages future developments toward the clinical applications of FGFR2.

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Year:  2013        PMID： 24134151     DOI： 10.1586/17474124.2013.837804

Source DB:  PubMed          Journal:  Expert Rev Gastroenterol Hepatol        ISSN： 1747-4124            Impact factor:   3.869


  10 in total

1.  MicroRNA-195 inhibits human gastric cancer by directly targeting basic fibroblast growth factor.

Authors:  J Wang; L Li; M Jiang; Y Li
Journal:  Clin Transl Oncol       Date:  2017-05-12       Impact factor: 3.405

Review 2.  Modular nanotransporters for targeted intracellular delivery of drugs: folate receptors as potential targets.

Authors:  Tatiana A Slastnikova; Andrey A Rosenkranz; Michael R Zalutsky; Alexander S Sobolev
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116

3.  Identification of novel peptoid agonists of fibroblast growth factor receptor using microarray-based screening.

Authors:  Junjie Fu; Amy Xia; Xin Qi
Journal:  Medchemcomm       Date:  2016-04-14       Impact factor: 3.597

4.  Novel findings about management of gastric cancer: a summary from 10th IGCC.

Authors:  Danila Penon; Letizia Cito; Antonio Giordano
Journal:  World J Gastroenterol       Date:  2014-07-21       Impact factor: 5.742

Review 5.  2b or Not 2b: How Opposing FGF Receptor Splice Variants Are Blocking Progress in Precision Oncology.

Authors:  Richard J Epstein; Li Jun Tian; Yan Fei Gu
Journal:  J Oncol       Date:  2021-04-30       Impact factor: 4.375

6.  The anti-apoptotic and prognostic value of fibroblast growth factor 9 in gastric cancer.

Authors:  Chuanli Ren; Hui Chen; Chongxu Han; Deyuan Fu; Fuan Wang; Daxin Wang; Li Ma; Lin Zhou; Dongsheng Han
Journal:  Oncotarget       Date:  2016-06-14

7.  FGF7/FGFR2 signal promotes invasion and migration in human gastric cancer through upregulation of thrombospondin-1.

Authors:  Tingting Huang; Lei Wang; Dian Liu; Piao Li; Huihua Xiong; Liang Zhuang; Li Sun; Xianglin Yuan; Hong Qiu
Journal:  Int J Oncol       Date:  2017-03-22       Impact factor: 5.650

Review 8.  Bone remodeling induced by mechanical forces is regulated by miRNAs.

Authors:  Yue Wang; Lingfei Jia; Yunfei Zheng; Weiran Li
Journal:  Biosci Rep       Date:  2018-07-02       Impact factor: 3.840

9.  The association of genetic variants in FGFR2 with osteoporosis susceptibility in Chinese Han population.

Authors:  Yang Yang; Mengxue Fei; Xinying Zhou; Yuejun Li; Dadi Jin
Journal:  Biosci Rep       Date:  2019-06-04       Impact factor: 3.840

10.  Patient-Derived Gastric Carcinoma Xenograft Mouse Models Faithfully Represent Human Tumor Molecular Diversity.

Authors:  Tianwei Zhang; Lin Zhang; Shuqiong Fan; Meizhuo Zhang; Haihua Fu; Yuanjie Liu; Xiaolu Yin; Hao Chen; Liang Xie; Jingchuan Zhang; Paul R Gavine; Yi Gu; Xingzhi Ni; Xinying Su
Journal:  PLoS One       Date:  2015-07-28       Impact factor: 3.240
  10 in total

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