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Literature DB >> 24130045

Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.

Goutam Chowdhury¹, Sung-Hee Cho, Anthony E Pegg, F Peter Guengerich.

Abstract

A combination of chemical modifications and LC-tandem MS was used for the structure elucidation of various ethylene crosslinks of DNA with O(6) -alkylguanine-DNA alkyltransferase (AGT, see picture). The elucidation of the chemical structures of such DNA-protein crosslinks is necessary to understand mechanisms of mutagenesis.

Entities: CellLine Chemical Disease Gene Species

Keywords: DNA adducts; DNA damage; DNA-protein crosslinks; hydrogenation; mutations

Mesh：

Substances：

Year: 2013 PMID： 24130045 PMCID： PMC4048925 DOI： 10.1002/anie.201307580

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

19 in total

1. S-(2-chloroethyl)glutathione-generated p53 mutation spectra are influenced by differential repair rates more than sites of initial dna damage.

Authors: J Gerardo Valadez; F Peter Guengerich
Journal: J Biol Chem Date: 2004-01-07 Impact factor: 5.157

2. Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide.

Authors: J L Cmarik; W G Humphreys; K L Bruner; R S Lloyd; C Tibbetts; F P Guengerich
Journal: J Biol Chem Date: 1992-04-05 Impact factor: 5.157

3. Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.

Authors: N Ozawa; F P Guengerich
Journal: Proc Natl Acad Sci U S A Date: 1983-09 Impact factor: 11.205

4. Repair of DNA-polypeptide crosslinks by human excision nuclease.

Authors: Joyce T Reardon; Aziz Sancar
Journal: Proc Natl Acad Sci U S A Date: 2006-03-06 Impact factor: 11.205

5. Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydroxybutyl]glutathione by DNA polymerases.

Authors: Sung-Hee Cho; F Peter Guengerich
Journal: Chem Res Toxicol Date: 2013-06-04 Impact factor: 3.739

6. Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium.

Authors: R Thier; S E Pemble; H Kramer; J B Taylor; F P Guengerich; B Ketterer
Journal: Carcinogenesis Date: 1996-01 Impact factor: 4.944

7. Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides.

Authors: D Sagher; B Strauss
Journal: Biochemistry Date: 1983-09-13 Impact factor: 3.162

8. Chemical modifications of transfer RNA species. Desulfurization with Raney nickel.

Authors: S M Hecht; L H Kirkegaard; R M Bock
Journal: Proc Natl Acad Sci U S A Date: 1971-01 Impact factor: 11.205

9. Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.

Authors: Liping Liu; Anthony E Pegg; Kevin M Williams; F Peter Guengerich
Journal: J Biol Chem Date: 2002-07-31 Impact factor: 5.157

10. Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.

Authors: Liping Liu; David L Hachey; Gerardo Valadez; Kevin M Williams; F Peter Guengerich; Natalia A Loktionova; Sreenivas Kanugula; Anthony E Pegg
Journal: J Biol Chem Date: 2003-11-25 Impact factor: 5.157

10 in total

1. Characterization of thioether-linked protein adducts of DNA using a Raney-Ni-mediated desulfurization method and liquid chromatography-electrospray-tandem mass spectrometry.

Authors: Goutam Chowdhury; F Peter Guengerich
Journal: Curr Protoc Nucleic Acid Chem Date: 2015-03-09

2. Synthesis and Characterization of Site-Specific O⁶ -Alkylguanine DNA-Alkyl Transferase-Oligonucleotide Crosslinks.

Authors: Pratibha P Ghodke; Matthew E Albertolle; Kevin M Johnson; F Peter Guengerich
Journal: Curr Protoc Nucleic Acid Chem Date: 2019-01-18

3. Formation of S-[2-(N⁶-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases.

Authors: Carl A Sedgeman; Yan Su; F Peter Guengerich
Journal: Chem Res Toxicol Date: 2017-04-14 Impact factor: 3.739

4. Structure elucidation of DNA-protein crosslinks by using reductive desulfurization and liquid chromatography-tandem mass spectrometry.

Authors: Susith Wickramaratne; Natalia Y Tretyakova
Journal: Chembiochem Date: 2014-01-16 Impact factor: 3.164

5. In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.

Authors: Sung-Hee Cho; F Peter Guengerich
Journal: Chem Res Toxicol Date: 2013-11-06 Impact factor: 3.739

6. The Natural Products Withaferin A and Withanone from the Medicinal Herb Withania somnifera Are Covalent Inhibitors of the SARS-CoV-2 Main Protease.

Authors: Shayantani Chakraborty; Dibyendu Mallick; Mausumi Goswami; F Peter Guengerich; Anindita Chakrabarty; Goutam Chowdhury
Journal: J Nat Prod Date: 2022-09-13 Impact factor: 4.803

10. DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera (Ashwagandha).

Authors: Shazia Siddiqui; Nabeel Ahmed; Mausumi Goswami; Anindita Chakrabarty; Goutam Chowdhury
Journal: Curr Res Toxicol Date: 2021-02-16