Literature DB >> 24436288

Structure elucidation of DNA-protein crosslinks by using reductive desulfurization and liquid chromatography-tandem mass spectrometry.

Susith Wickramaratne1, Natalia Y Tretyakova.   

Abstract

Easier with ethyl: Guengerich and co-workers have developed a powerful new approach to the structure elucidation of hydrolytically stable AGT-DNA crosslinks by reductive desulfurization of the thioether linkage between AGT and DNA to convert cysteine DPCs to the corresponding ethyl-DNA adducts, which can be readily characterized by LC-MSn.
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  DNA-protein crosslinks; O6-alkylguanine DNA alkyltransferase; desulfurization; labile and nonlabile DNA adducts; liquid chromatography-tandem mass spectrometry

Mesh：

Substances：

Year:  2014        PMID： 24436288      PMCID： PMC4034465          DOI： 10.1002/cbic.201300757

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  26 in total

1.  Mammalian cells expressing Escherichia coli O6-alkylguanine-DNA alkyltransferases are hypersensitive to dibromoalkanes.

Authors:  N Abril; G P Margison
Journal:  Chem Res Toxicol       Date:  1999-06       Impact factor: 3.739

Review 2.  Repair and biochemical effects of DNA-protein crosslinks.

Authors:  Hiroshi Ide; Mahmoud I Shoulkamy; Toshiaki Nakano; Mayumi Miyamoto-Matsubara; Amir M H Salem
Journal:  Mutat Res       Date:  2010-12-24       Impact factor: 2.433

3.  Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase.

Authors:  K S Ellison; E Dogliotti; T D Connors; A K Basu; J M Essigmann
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

Review 4.  DNA-protein crosslinks: their induction, repair, and biological consequences.

Authors:  Sharon Barker; Michael Weinfeld; David Murray
Journal:  Mutat Res       Date:  2005-01-05       Impact factor: 2.433

5.  Mutagenic potential of guanine N2 adducts of butadiene mono- and diolepoxide.

Authors:  J R Carmical; M Zhang; L Nechev; C M Harris; T M Harris; R S Lloyd
Journal:  Chem Res Toxicol       Date:  2000-01       Impact factor: 3.739

6.  Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane.

Authors:  Rachel Loeber; Mathur Rajesh; Qingming Fang; Anthony E Pegg; Natalia Tretyakova
Journal:  Chem Res Toxicol       Date:  2006-05       Impact factor: 3.739

Review 7.  Oxidative stress in diabetes and Alzheimer's disease.

Authors:  V Prakash Reddy; Xiongwei Zhu; George Perry; Mark A Smith
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

8.  DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells.

Authors:  Natalia Y Tretyakova; Erin D Michaelson-Richie; Teshome B Gherezghiher; Jamie Kurtz; Xun Ming; Susith Wickramaratne; Melissa Campion; Sreenivas Kanugula; Anthony E Pegg; Colin Campbell
Journal:  Biochemistry       Date:  2013-04-24       Impact factor: 3.162

9.  Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.

Authors:  Liping Liu; Anthony E Pegg; Kevin M Williams; F Peter Guengerich
Journal:  J Biol Chem       Date:  2002-07-31       Impact factor: 5.157

10.  Real-Time Analysis of Specific Protein-DNA Interactions with Surface Plasmon Resonance.

Authors:  Markus Ritzefeld; Norbert Sewald
Journal:  J Amino Acids       Date:  2012-02-28
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