| Literature DB >> 24129958 |
Leonardo G Monte1, Tatiane Santi-Gadelha, Larissa B Reis, Elizandra Braganhol, Rafael F Prietsch, Odir A Dellagostin, Rodrigo Rodrigues E Lacerda, Carlos A A Gadelha, Fabricio R Conceição, Luciano S Pinto.
Abstract
The anti-tumor effects of a newly-discovered lectin, isolated from okra, Abelmoschus esculentus (AEL), were investigated in human breast cancer (MCF7) and skin fibroblast (CCD-1059 sk) cells. AEL induced significant cell growth inhibition (63 %) in MCF7 cells. The expression of pro-apoptotic caspase-3, caspase-9, and p21 genes was increased in MCF7 cells treated with AEL, compared to those treated with controls. In addition, AEL treatment increased the Bax/Bcl-2 ratio in MCF7 cells. Flow cytometry also indicated that cell death (72 %) predominantly occurred through apoptosis. Thus, AEL in its native form promotes selective antitumor effects in human breast cancer cells and may represent a potential therapeutic to combat human breast cancer.Entities:
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Year: 2013 PMID： 24129958 DOI： 10.1007/s10529-013-1382-4
Source DB: PubMed Journal: Biotechnol Lett ISSN： 0141-5492 Impact factor: 2.461