BACKGROUND AND PURPOSE: To measure the geometric uncertainty resulting from intra-fraction motion and intra-observer image matching, for patients having image-guided prostate radiotherapy on TomoTherapy. MATERIAL AND METHODS: All patients had already been selected for prostate radiotherapy on TomoTherapy, with daily MV-CT imaging. The study involved performing an additional MV-CT image at the end of treatment, on 5 occasions during the course of 37 treatments. 54 patients were recruited to the study. A new formula was derived to calculate the PTV margin for intra-fraction motion. RESULTS: The mean values of the intra-fraction differences were 0.0mm, 0.5mm, 0.5mm and 0.0° for LR, SI, AP and roll, respectively. The corresponding standard deviations were 1.1mm, 0.8mm, 0.8mm and 0.6° for systematic uncertainties (Σ), 1.3mm, 2.0mm, 2.2mm and 0.3° for random uncertainties (σ). This intra-fraction motion requires margins of 2.2mm in LR, 2.1mm in SI and 2.1mm in AP directions. Inclusion of estimates of the effect of rotations and matching errors increases these margins to approximately 4mm in LR and 5mm in SI and AP directions. CONCLUSIONS: A new margin recipe has been developed to calculate margins for intra-fraction motion. This recipe is applicable to any measurement technique that is based on the difference between images taken before and after treatment.
BACKGROUND AND PURPOSE: To measure the geometric uncertainty resulting from intra-fraction motion and intra-observer image matching, for patients having image-guided prostate radiotherapy on TomoTherapy. MATERIAL AND METHODS: All patients had already been selected for prostate radiotherapy on TomoTherapy, with daily MV-CT imaging. The study involved performing an additional MV-CT image at the end of treatment, on 5 occasions during the course of 37 treatments. 54 patients were recruited to the study. A new formula was derived to calculate the PTV margin for intra-fraction motion. RESULTS: The mean values of the intra-fraction differences were 0.0mm, 0.5mm, 0.5mm and 0.0° for LR, SI, AP and roll, respectively. The corresponding standard deviations were 1.1mm, 0.8mm, 0.8mm and 0.6° for systematic uncertainties (Σ), 1.3mm, 2.0mm, 2.2mm and 0.3° for random uncertainties (σ). This intra-fraction motion requires margins of 2.2mm in LR, 2.1mm in SI and 2.1mm in AP directions. Inclusion of estimates of the effect of rotations and matching errors increases these margins to approximately 4mm in LR and 5mm in SI and AP directions. CONCLUSIONS: A new margin recipe has been developed to calculate margins for intra-fraction motion. This recipe is applicable to any measurement technique that is based on the difference between images taken before and after treatment.
Authors: Daniel Pham; Eric Simiele; Dylan Breitkreutz; Dante Capaldi; Bin Han; Murat Surucu; Seyi Oderinde; Lucas Vitzthum; Michael Gensheimer; Hilary Bagshaw; Alex Chin; Lei Xing; D T Chang; Natalyia Kovalchuk Journal: Technol Cancer Res Treat Date: 2022 Jan-Dec
Authors: J Scaife; K Harrison; M Romanchikova; A Parker; M Sutcliffe; S Bond; S Thomas; S Freeman; R Jena; A Bates; N Burnet Journal: Br J Radiol Date: 2014-08-20 Impact factor: 3.039
Authors: L E A Shelley; J E Scaife; M Romanchikova; K Harrison; J R Forman; A M Bates; D J Noble; R Jena; M A Parker; M P F Sutcliffe; S J Thomas; N G Burnet Journal: Radiother Oncol Date: 2017-04-28 Impact factor: 6.280
Authors: Leila E A Shelley; Michael P F Sutcliffe; Simon J Thomas; David J Noble; Marina Romanchikova; Karl Harrison; Amy M Bates; Neil G Burnet; Raj Jena Journal: Phys Imaging Radiat Oncol Date: 2020-04
Authors: Christoph Oehler; Nina Roehner; Marcin Sumila; Jürgen Curschmann; Fabrizio Storelli; Daniel Rudolf Zwahlen; Uwe Schneider Journal: Curr Oncol Date: 2022-08-31 Impact factor: 3.109