Literature DB >> 2412878

A study on the pharmacokinetics in mouse of adenine-9-beta-D-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin.

L Fiume, B Bassi, C Busi, A Mattioli, T Wieland.   

Abstract

In plasma of mice injected with adenine-9-beta-D-arabinofuranoside monophosphate (ara-AMP) coupled to human lactosaminated serum albumin (L-HSA) some of the ara-AMP molecules are enzymatically released, whereas others remain linked to L-HSA. Evidence has been obtained that ara-AMP is not deaminated when it is conjugated to L-HSA, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative.

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Year:  1985        PMID： 2412878     DOI： 10.1007/bf01952078

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Production of antibodies to amanitins as the basis for their radioimmunoassay.

Authors:  L Fiume; C Busi; G Campadelli-Fiume; C Franceschi
Journal:  Experientia       Date:  1975-10-15

2.  Proteins containing reductively aminated disaccharides. Synthesis and chemical characterization.

Authors:  B A Schwartz; G R Gray
Journal:  Arch Biochem Biophys       Date:  1977-06       Impact factor: 4.013

3.  Effect of liver disease on pharmacokinetics and toxicity of 9-beta-D-arabinofuranosyladenine-5-phosphate.

Authors:  J K Preiksaitis; B Lank; P K Ng; L Brox; G A LePage; D L Tyrrell
Journal:  J Infect Dis       Date:  1981-10       Impact factor: 5.226

4.  Hepatocyte targeting of adenine-9-beta-D-arabinofuranoside 5' -monophosphate (ara-AMP) coupled to lactosaminated albumin.

Authors:  L Fiume; C Busi; A Mattioli; P G Balboni; G Barbanti-Brodano
Journal:  FEBS Lett       Date:  1981-07-06       Impact factor: 4.124

Review 5.  Carbohydrate-specific receptors of the liver.

Authors:  G Ashwell; J Harford
Journal:  Annu Rev Biochem       Date:  1982       Impact factor: 23.643

6.  Protein labeling by reductive alkylation.

Authors:  N Jentoft; D G Dearborn
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

7.  Lactosaminated human serum albumin as hepatotropic drug carrier. Rate of uptake by mouse liver.

Authors:  L Fiume; C Busi; A Mattioli
Journal:  FEBS Lett       Date:  1982-09-06       Impact factor: 4.124

8.  Selective inhibition of Ectromelia virus DNA synthesis in hepatocytes by adenine-9-beta-D-arabinofuranoside (ara-A) and adenine-9-beta-D-arabinofuranoside 5'-monophosphate (ara-AMP) conjugated to asialofetuin.

Authors:  L Fiume; A Mattioli; C Busi; P G Balboni; G Barbanti-Brodano; J De Vries; R Altmann; T Wieland
Journal:  FEBS Lett       Date:  1980-07-28       Impact factor: 4.124

9.  Selective penetration and pharmacological activity of lactosaminated albumin conjugates of adenine arabinoside 5-monophosphate (ara-AMP) in mouse liver.

Authors:  L Fiume; A Mattioli; C Busi; C Accorsi
Journal:  Gut       Date:  1984-12       Impact factor: 23.059

10.  Effect of reductive lactosamination on the hepatic uptake of bovine pancreatic ribonuclease A dimer.

Authors:  G Wilson
Journal:  J Biol Chem       Date:  1978-04-10       Impact factor: 5.157
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