Literature DB >> 24127593

Cytosolic reducing power preserves glutamate in retina.

Jianhai Du1, Whitney Cleghorn, Laura Contreras, Jonathan D Linton, Guy C-K Chan, Andrei O Chertov, Takeyori Saheki, Viren Govindaraju, Martin Sadilek, Jorgina Satrústegui, James B Hurley.   

Abstract

Glutamate in neurons is an important excitatory neurotransmitter, but it also is a key metabolite. We investigated how glutamate in a neural tissue is protected from catabolism. Flux analysis using (13)C-labeled fuels revealed that retinas use activities of the malate aspartate shuttle to protect >98% of their glutamate from oxidation in mitochondria. Isolation of glutamate from the oxidative pathway relies on cytosolic NADH/NAD(+), which is influenced by extracellular glucose, lactate, and pyruvate.

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Year:  2013        PMID： 24127593      PMCID： PMC3831988          DOI： 10.1073/pnas.1311193110

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

Review 1.  Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca(2+) signaling in neuronal mitochondria.

Authors:  Jorgina Satrústegui; Laura Contreras; Milagros Ramos; Patricia Marmol; Araceli del Arco; Takeyori Saheki; Beatriz Pardo
Journal:  J Neurosci Res       Date:  2007-11-15       Impact factor: 4.164

Review 2.  The mitochondrial oxoglutarate carrier: from identification to mechanism.

Authors:  Magnus Monné; Daniela Valeria Miniero; Vito Iacobazzi; Faustino Bisaccia; Giuseppe Fiermonte
Journal:  J Bioenerg Biomembr       Date:  2013-02       Impact factor: 2.945

3.  Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

Authors:  Sarah-Maria Fendt; Eric L Bell; Mark A Keibler; Benjamin A Olenchock; Jared R Mayers; Thomas M Wasylenko; Natalie I Vokes; Leonard Guarente; Matthew G Vander Heiden; Gregory Stephanopoulos
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

4.  High-density presynaptic transporters are required for glutamate removal from the first visual synapse.

Authors:  Jun Hasegawa; Takehisa Obara; Kohichi Tanaka; Masao Tachibana
Journal:  Neuron       Date:  2006-04-06       Impact factor: 17.173

5.  Nuclear magnetic resonance and biochemical measurements of glucose utilization in the cone-dominant ground squirrel retina.

Authors:  Barry S Winkler; Catherine A Starnes; Brandon S Twardy; Diane Brault; R Craig Taylor
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-06-19       Impact factor: 4.799

6.  AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway.

Authors:  Irene Llorente-Folch; Ignasi Sahún; Laura Contreras; María José Casarejos; Josep María Grau; Takeyori Saheki; María Angeles Mena; Jorgina Satrústegui; Mara Dierssen; Beatriz Pardo
Journal:  J Neurochem       Date:  2013-02       Impact factor: 5.372

7.  Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia.

Authors:  Y Xu; M S Ola; D A Berkich; T W Gardner; A J Barber; F Palmieri; S M Hutson; K F LaNoue
Journal:  J Neurochem       Date:  2007-04       Impact factor: 5.372

Review 8.  The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.

Authors:  Ralph J DeBerardinis; Julian J Lum; Georgia Hatzivassiliou; Craig B Thompson
Journal:  Cell Metab       Date:  2008-01       Impact factor: 27.287

9.  Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways.

Authors:  Laura Contreras; Jorgina Satrústegui
Journal:  J Biol Chem       Date:  2009-01-07       Impact factor: 5.157

10.  Kinetic flux profiling for quantitation of cellular metabolic fluxes.

Authors:  Jie Yuan; Bryson D Bennett; Joshua D Rabinowitz
Journal:  Nat Protoc       Date:  2008       Impact factor: 13.491
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  34 in total

Review 1.  Probing Metabolism in the Intact Retina Using Stable Isotope Tracers.

Authors:  Jianhai Du; Jonathan D Linton; James B Hurley
Journal:  Methods Enzymol       Date:  2015-06-14       Impact factor: 1.600

2.  Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.

Authors:  Patrick A Carroll; Daniel Diolaiti; Lisa McFerrin; Haiwei Gu; Danijel Djukovic; Jianhai Du; Pei Feng Cheng; Sarah Anderson; Michelle Ulrich; James B Hurley; Daniel Raftery; Donald E Ayer; Robert N Eisenman
Journal:  Cancer Cell       Date:  2015-01-29       Impact factor: 31.743

3.  Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

Authors:  Chendong Yang; Bookyung Ko; Christopher T Hensley; Lei Jiang; Ajla T Wasti; Jiyeon Kim; Jessica Sudderth; Maria Antonietta Calvaruso; Lloyd Lumata; Matthew Mitsche; Jared Rutter; Matthew E Merritt; Ralph J DeBerardinis
Journal:  Mol Cell       Date:  2014-10-21       Impact factor: 17.970

4.  Mitochondria Maintain Distinct Ca2+ Pools in Cone Photoreceptors.

Authors:  Michelle M Giarmarco; Whitney M Cleghorn; Stephanie R Sloat; James B Hurley; Susan E Brockerhoff
Journal:  J Neurosci       Date:  2017-01-23       Impact factor: 6.167

5.  Analysis of Coenzymes and Antioxidants in Tissue and Blood Using 1D 1H NMR Spectroscopy.

Authors:  G A Nagana Gowda; Daniel Raftery
Journal:  Methods Mol Biol       Date:  2019

6.  Proline mediates metabolic communication between retinal pigment epithelial cells and the retina.

Authors:  Michelle Yam; Abbi L Engel; Yekai Wang; Siyan Zhu; Allison Hauer; Rui Zhang; Daniel Lohner; Jiancheng Huang; Marlee Dinterman; Chen Zhao; Jennifer R Chao; Jianhai Du
Journal:  J Biol Chem       Date:  2019-05-19       Impact factor: 5.157

7.  Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.

Authors:  Lijuan Zhang; Jianhai Du; Sally Justus; Chun-Wei Hsu; Luis Bonet-Ponce; Wen-Hsuan Wu; Yi-Ting Tsai; Wei-Pu Wu; Yading Jia; Jimmy K Duong; Vinit B Mahajan; Chyuan-Sheng Lin; Shuang Wang; James B Hurley; Stephen H Tsang
Journal:  J Clin Invest       Date:  2016-11-14       Impact factor: 14.808

8.  Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.

Authors:  Ken J Lindsay; Jianhai Du; Stephanie R Sloat; Laura Contreras; Jonathan D Linton; Sally J Turner; Martin Sadilek; Jorgina Satrústegui; James B Hurley
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-13       Impact factor: 11.205

9.  The retinal pigment epithelium utilizes fatty acids for ketogenesis.

Authors:  Jeffrey Adijanto; Jianhai Du; Cynthia Moffat; Erin L Seifert; James B Hurle; Nancy J Philp
Journal:  J Biol Chem       Date:  2014-07-25       Impact factor: 5.157

10.  Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina.

Authors:  Jianhai Du; Austin Rountree; Whitney M Cleghorn; Laura Contreras; Ken J Lindsay; Martin Sadilek; Haiwei Gu; Danijel Djukovic; Dan Raftery; Jorgina Satrústegui; Mark Kanow; Lawrence Chan; Stephen H Tsang; Ian R Sweet; James B Hurley
Journal:  J Biol Chem       Date:  2015-12-16       Impact factor: 5.157
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