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Literature DB >> 2412607

Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release.

Abstract

Quantitative modeling indicates that, in presynaptic terminals, the intracellular calcium concentration profile during inward calcium current is characterized by discrete peaks of calcium immediately adjacent to the calcium channels. This restriction of intracellular calcium concentration suggests a remarkably well specified intracellular architecture such that calcium, as a second messenger, may regulate particular intracellular domains with a great degree of specificity.

Entities: Chemical

Mesh：

Substances：
Ion Channels
Calcium

Year: 1985 PMID： 2412607 PMCID： PMC1329362 DOI： 10.1016/S0006-3495(85)83804-2

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

39 in total

1. Presynaptic calcium currents and their relation to synaptic transmission: voltage clamp study in squid giant synapse and theoretical model for the calcium gate.

Authors: R Llinás; I Z Steinberg; K Walton
Journal: Proc Natl Acad Sci U S A Date: 1976-08 Impact factor: 11.205

Review 9. Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.

Authors: L S Satin
Journal: Endocrine Date: 2000-12 Impact factor: 3.633

10. Mechanisms of calcium influx into hippocampal spines: heterogeneity among spines, coincidence detection by NMDA receptors, and optical quantal analysis.

Authors: R Yuste; A Majewska; S S Cash; W Denk
Journal: J Neurosci Date: 1999-03-15 Impact factor: 6.167

Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release.

1. Presynaptic calcium currents and their relation to synaptic transmission: voltage clamp study in squid giant synapse and theoretical model for the calcium gate.

2. Calcium diffusion in transient and steady states in muscle.

3. Artificial deciliation causes loss of calcium-dependent responses in Paramecium.

4. Depolarization-release coupling systems in neurons.

5. A theoretical explanation for some effects of calcium on the facilitation of neurotransmitter release.

6. Calcium conductances in Purkinje cell dendrites: their role in development and integration.

Review 7. Calmodulin--an intracellular calcium receptor.

8. Uptake and binding of calcium by axoplasm isolated from giant axons of Loligo and Myxicola.

9. Localization of calcium channels in Paramecium caudatum.

10. Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells.

1. Implications of G-protein-mediated Ca2+ channel inhibition for neurotransmitter release and facilitation.

2. Microdomains of high calcium are not required for exocytosis in RBL-2H3 mucosal mast cells.

3. Contributions of residual calcium to fast synaptic transmission.

4. Measurement of action potential-induced presynaptic calcium domains at a cultured neuromuscular junction.

5. Critical determinants of Ca(2+)-dependent inactivation within an EF-hand motif of L-type Ca(2+) channels.

6. The probability of quantal secretion near a single calcium channel of an active zone.

7. Properties of a model of Ca++-dependent vesicle pool dynamics and short term synaptic depression.

8. Dual responses of CNS mitochondria to elevated calcium.

Review 9. Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.

10. Mechanisms of calcium influx into hippocampal spines: heterogeneity among spines, coincidence detection by NMDA receptors, and optical quantal analysis.