OBJECTIVE: Neo-vascularization is vital for an expansion and metastasis of a tumor and is influenced by a number of mediators. Mast cells are believed to release many pro-angiogenic mediators that may help in tumor expansion and invasion. This study describes the role of mast cells and angiogenesis in oral squamous cell carcinoma (OSCC). STUDY DESIGN: It was a prospective study in which 37 biopsies of well-differentiated OSCC were obtained. Micro-vessels were stained with cluster of differentiation (CD)-34 and mast cells were counted using the Toluidine blue stain. RESULTS: When compared to normal oral mucosal tissue, it was seen that micro-vessel density and mast cell density indeed increases significantly in squamous cell carcinoma; however, they are not correlated to each other. CONCLUSION: This study reports that angiogenesis does increase in OSCC and mast cells also invade the peri-tumor tissue, but they are not directly correlated.
OBJECTIVE: Neo-vascularization is vital for an expansion and metastasis of a tumor and is influenced by a number of mediators. Mast cells are believed to release many pro-angiogenic mediators that may help in tumor expansion and invasion. This study describes the role of mast cells and angiogenesis in oral squamous cell carcinoma (OSCC). STUDY DESIGN: It was a prospective study in which 37 biopsies of well-differentiated OSCC were obtained. Micro-vessels were stained with cluster of differentiation (CD)-34 and mast cells were counted using the Toluidine blue stain. RESULTS: When compared to normal oral mucosal tissue, it was seen that micro-vessel density and mast cell density indeed increases significantly in squamous cell carcinoma; however, they are not correlated to each other. CONCLUSION: This study reports that angiogenesis does increase in OSCC and mast cells also invade the peri-tumor tissue, but they are not directly correlated.
Authors: Mircea Tampa; Madalina Irina Mitran; Cristina Iulia Mitran; Maria Isabela Sarbu; Clara Matei; Ilinca Nicolae; Ana Caruntu; Sandra Milena Tocut; Mircea Ioan Popa; Constantin Caruntu; Simona Roxana Georgescu Journal: J Immunol Res Date: 2018-11-12 Impact factor: 4.818
Authors: Devandir Antonio de Souza Junior; Antonio Carlos Borges; Ana Carolina Santana; Constance Oliver; Maria Célia Jamur Journal: PLoS One Date: 2015-12-03 Impact factor: 3.240