Literature DB >> 24125889

Novel cancer-targeting SPECT/NIRF dual-modality imaging probe (99m)Tc-PC-1007: synthesis and biological evaluation.

Yi Zhang1, Li Xiao, Kosta Popovic, Xiuzhen Xie, Mahendra D Chordia, Leland W K Chung, Mark B Williams, Wei Yue, Dongfeng Pan.   

Abstract

Synthesis, characterization, in vitro and in vivo biological evaluation of a heptamethine cyanine based dual-mode single-photon emission computed tomography (SPECT)/near infrared fluorescence (NIRF) imaging probe (99m)Tc-PC-1007 is described. (99m)Tc-PC-1007 exhibited preferential accumulation in human breast cancer MCF-7 cells. Cancer-specific SPECT/CT and NIRF imaging of (99m)Tc-PC-1007 was performed in a breast cancer xenograft model. The probe uptake ratio of tumor to control (spinal cord) was calculated to be 4.02±0.56 at 6 h post injection (pi) and 8.50±1.41 at 20 h pi (P<0.0001). Pharmacokinetic parameters such as blood clearance and organ distribution were assessed.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  99m-Technetium; Breast cancer; Dual-modality; Heptamethine cyanine dye; Near infrared fluorescence; SPECT

Mesh：

Substances：

Year:  2013        PMID： 24125889      PMCID： PMC4710472          DOI： 10.1016/j.bmcl.2013.09.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  28 in total

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  9 in total

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