OBJECTIVE: To determine the mortality rate and risk factors for in-hospital death among hospitalised human immunodeficiency virus (HIV) negative tuberculosis (TB) patients in poor urban areas in the Philippines. DESIGN: A cross-sectional study was conducted at a national infectious disease hospital in Manila City. The target population was patients aged ≥ 13 years with all forms of HIV-negative TB admitted from October to December 2009. Demographic and clinical information was collected from medical charts, and risk of in-hospital death was measured. RESULTS: Of 407 HIV-negative TB patients, four were excluded due to missing records, and 403 were included in the analysis. The majority were poor urban residents (90%), and 66% were males. Overall, 37.5% of hospitalised patients died in the hospital (151/403), 30% of whom died before the third day of hospitalisation. Risk factor analysis demonstrated that complications of bacterial pneumonia had the greatest effect on in-hospital death (aOR 4.53, 95%CI 2.65-7.72), followed by anorexia (aOR 3.01, 95%CI 1.55-5.84), anaemia (haemoglobin <10 g/dl, aOR 2.35, 95%CI 1.34-4.13) and older age (aged ≥ 50 years, aOR 1.85, 95%CI 1.08-3.17). The presence of haemoptysis (aOR 0.44, 95%CI 0.25-0.80) was associated with improved survival. CONCLUSION: Mortality among hospitalised HIV-negative TB patients was extremely high in poor urban areas in the Philippines.
OBJECTIVE: To determine the mortality rate and risk factors for in-hospital death among hospitalised human immunodeficiency virus (HIV) negative tuberculosis (TB) patients in poor urban areas in the Philippines. DESIGN: A cross-sectional study was conducted at a national infectious disease hospital in Manila City. The target population was patients aged ≥ 13 years with all forms of HIV-negative TB admitted from October to December 2009. Demographic and clinical information was collected from medical charts, and risk of in-hospital death was measured. RESULTS: Of 407 HIV-negative TB patients, four were excluded due to missing records, and 403 were included in the analysis. The majority were poor urban residents (90%), and 66% were males. Overall, 37.5% of hospitalised patients died in the hospital (151/403), 30% of whom died before the third day of hospitalisation. Risk factor analysis demonstrated that complications of bacterial pneumonia had the greatest effect on in-hospital death (aOR 4.53, 95%CI 2.65-7.72), followed by anorexia (aOR 3.01, 95%CI 1.55-5.84), anaemia (haemoglobin <10 g/dl, aOR 2.35, 95%CI 1.34-4.13) and older age (aged ≥ 50 years, aOR 1.85, 95%CI 1.08-3.17). The presence of haemoptysis (aOR 0.44, 95%CI 0.25-0.80) was associated with improved survival. CONCLUSION: Mortality among hospitalised HIV-negative TB patients was extremely high in poor urban areas in the Philippines.
Authors: Bruce J Kirenga; Jonathan Levin; Irene Ayakaka; William Worodria; Nancy Reilly; Francis Mumbowa; Helen Nabanjja; Grace Nyakoojo; Kevin Fennelly; Susan Nakubulwa; Moses Joloba; Alphonse Okwera; Kathleen D Eisenach; Ruth McNerney; Alison M Elliott; Roy D Mugerwa; Peter G Smith; Jerrold J Ellner; Edward C Jones-López Journal: PLoS One Date: 2014-03-07 Impact factor: 3.240
Authors: Laura V White; Nathaniel Lee; Flora P Marin; Naomi R Saludar; Tansy Edwards; Sharon E Cox Journal: PLoS One Date: 2019-05-16 Impact factor: 3.240
Authors: Nathaniel Lee; Laura V White; Flora P Marin; Naomi R Saludar; Marietta B Solante; Rosario J C Tactacan-Abrenica; Rugaiya W Calapis; Motoi Suzuki; Nobuo Saito; Koya Ariyoshi; Christopher M Parry; Tansy Edwards; Sharon E Cox Journal: PLoS One Date: 2019-06-27 Impact factor: 3.240
Authors: Arista Nienaber; Jeannine Baumgartner; Robin C Dolman; Mumin Ozturk; Lizelle Zandberg; Frank E A Hayford; Frank Brombacher; Renee Blaauw; Suraj P Parihar; Cornelius M Smuts; Linda Malan Journal: Nutrients Date: 2020-09-22 Impact factor: 5.717