Literature DB >> 2412230

Interaction of endothelial cell growth factor with heparin: characterization by receptor and antibody recognition.

A B Schreiber, J Kenney, W J Kowalski, R Friesel, T Mehlman, T Maciag.   

Abstract

Endothelial cell growth factor (ECGF) binds specifically in vitro to membrane receptors present on the surface of several cell types, including murine and human endothelial cells and fibroblasts. Monoclonal antibodies prepared against ECGF that inhibit the mitogenic activity of the growth factor prevent receptor occupancy by the ligand. Heparin interacts structurally with ECGF [Maciag, T., Mehlman, T., Friesel, R. & Schreiber, A. B. (1984) Science 225, 932-935], potentiates the mitogenic activity of the polypeptide, restores the biological activity to inactivate ECGF, enhances the affinity of the ligand to cell surface receptors, and modifies antibody recognition of ECGF. These data suggest that the association between heparin and ECGF induces a conformational change in the polypeptide that increases or stabilizes the biological activity of the mitogen.

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Year:  1985        PMID： 2412230      PMCID： PMC391007          DOI： 10.1073/pnas.82.18.6138

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  28 in total

1.  Liberation of immunoreactive somatomedin-C from its binding proteins by proteolytic enzymes and heparin.

Authors:  D R Clemmons; L E Underwood; P G Chatelain; J J Van Wyk
Journal:  J Clin Endocrinol Metab       Date:  1983-02       Impact factor: 5.958

2.  Protamine is an inhibitor of angiogenesis.

Authors:  S Taylor; J Folkman
Journal:  Nature       Date:  1982-05-27       Impact factor: 49.962

3.  Purification, characterization, and biological properties of the eye-derived growth factor from retina: analogies with brain-derived growth factor.

Authors:  D Barritault; J Plouët; J Courty; Y Courtois
Journal:  J Neurosci Res       Date:  1982       Impact factor: 4.164

4.  An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization.

Authors:  T Maciag; J Cerundolo; S Ilsley; P R Kelley; R Forand
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

5.  High and low molecular weight forms of endothelial cell growth factor.

Authors:  T Maciag; G A Hoover; R Weinstein
Journal:  J Biol Chem       Date:  1982-05-25       Impact factor: 5.157

6.  Human platelet-derived growth factor. Purification and resolution into two active protein fractions.

Authors:  T F Deuel; J S Huang; R T Proffitt; J U Baenziger; D Chang; B B Kennedy
Journal:  J Biol Chem       Date:  1981-09-10       Impact factor: 5.157

7.  How to make a hybridoma.

Authors:  E A Lerner
Journal:  Yale J Biol Med       Date:  1981 Sep-Oct

8.  Organizational behavior of human umbilical vein endothelial cells.

Authors:  T Maciag; J Kadish; L Wilkins; M B Stemerman; R Weinstein
Journal:  J Cell Biol       Date:  1982-09       Impact factor: 10.539

9.  Bovine fibroblast growth factor: comparison of brain and pituitary preparations.

Authors:  S K Lemmon; M C Riley; K A Thomas; G A Hoover; T Maciag; R A Bradshaw
Journal:  J Cell Biol       Date:  1982-10       Impact factor: 10.539

10.  Mast cell heparin stimulates migration of capillary endothelial cells in vitro.

Authors:  R G Azizkhan; J C Azizkhan; B R Zetter; J Folkman
Journal:  J Exp Med       Date:  1980-10-01       Impact factor: 14.307
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  47 in total

1.  Heparin-binding growth factors and their receptors.

Authors:  B B Olwin
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

Review 2.  Growth factors and the skeletal system.

Authors:  E Canalis; T L McCarthy; M Centrella
Journal:  J Endocrinol Invest       Date:  1989-09       Impact factor: 4.256

3.  Effects of basic fibroblast growth factor on bone formation in vitro.

Authors:  E Canalis; M Centrella; T McCarthy
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808

4.  Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

Authors:  A Bradbury; R Possenti; E M Shooter; F Tirone
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

5.  The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.

Authors:  Huan Qiao; Yan Liu; Ruth A Veach; Lukasz Wylezinski; Jacek Hawiger
Journal:  J Biol Chem       Date:  2014-06-23       Impact factor: 5.157

6.  Acidic and basic fibroblast growth factors down-regulate collagen gene expression in keloid fibroblasts.

Authors:  E M Tan; S Rouda; S S Greenbaum; J H Moore; J W Fox; S Sollberg
Journal:  Am J Pathol       Date:  1993-02       Impact factor: 4.307

7.  Increase in the relative level of type V collagen during development and ageing of the placenta.

Authors:  M Iwahashi; A Ooshima; R Nakano
Journal:  J Clin Pathol       Date:  1996-11       Impact factor: 3.411

8.  Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).

Authors:  J A Winkles; R Friesel; W H Burgess; R Howk; T Mehlman; R Weinstein; T Maciag
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

9.  Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide.

Authors:  I P Oswald; I Eltoum; T A Wynn; B Schwartz; P Caspar; D Paulin; A Sher; S L James
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

10.  Refinement of the structure of human basic fibroblast growth factor at 1.6 A resolution and analysis of presumed heparin binding sites by selenate substitution.

Authors:  A E Eriksson; L S Cousens; B W Matthews
Journal:  Protein Sci       Date:  1993-08       Impact factor: 6.725
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