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Literature DB >> 24121031

Annexin A5 as a potential marker in tumors.

Boya Peng¹, Chunmei Guo, Hongwei Guan, Shuqing Liu, Ming-Zhong Sun.

Abstract

Annexin A5 (Anxa5) promotes pancreatic adenocarcinoma, sarcoma, tumorigenesis and progression of breast cancer and prostate cancer stem cells. It is involved with metastasis, invasion and development of squamous cell carcinoma, and facilitates nodal progression of bladder cancer and angiogenesis and progression of glioma. Anxa5 de-regulation is associated with drug resistance in nasopharyngeal carcinoma and gastric cancer. Although Anxa5 protein up-regulation promotes cervical cancer progression, it is markedly suppressed in cervical carcinoma cells. Anxa5 is negatively correlated with thyroid cancer malignancy. In this review, we explore the mechanisms of Anxa5 action in tumors. Anxa5 could be a predictive biomarker for tumor development, metastasis and invasion, and be of diagnostic, prognostic and therapeutic significance in cancer.

Entities: Disease Gene

Keywords: Annexin A5; Drug resistance; Malignancy; Tumor

Mesh：

Substances：

Year: 2013 PMID： 24121031 DOI： 10.1016/j.cca.2013.09.048

Source DB: PubMed Journal: Clin Chim Acta ISSN： 0009-8981 Impact factor: 3.786

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Cited

33 in total

Review 1. The IgG and IgM isotypes of anti-annexin A5 antibodies: relevance for primary antiphospholipid syndrome.

Authors: Mirjana Bećarević
Journal: J Thromb Thrombolysis Date: 2016-11 Impact factor: 2.300

2. Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells.

Authors: Berna Uygur; Evgenia Leikina; Kamran Melikov; Rafael Villasmil; Santosh K Verma; Calvin P H Vary; Leonid V Chernomordik
Journal: Mol Cancer Res Date: 2018-12-26 Impact factor: 5.852

3. Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.

Authors: Amber Ilyas; Zehra Hashim; Shamshad Zarina
Journal: Mol Cell Biochem Date: 2015-04-09 Impact factor: 3.396

4. Annexin V expression on CD4⁺ T cells with regulatory function.

Authors: Anna-Lena Bollinger; Thomas Bollinger; Jan Rupp; Kensuke Shima; Natalie Gross; Laura Padayachy; Rachel Chicheportiche; Gisella L Puga Yung; Jörg Dieter Seebach
Journal: Immunology Date: 2019-11-20 Impact factor: 7.397

5. Proteomic Investigation of Malignant Major Salivary Gland Tumors.

Authors: Veronica Seccia; Elena Navari; Elena Donadio; Claudia Boldrini; Federica Ciregia; Maurizio Ronci; Antonio Aceto; Iacopo Dallan; Antonio Lucacchini; Augusto Pietro Casani; Maria Rosa Mazzoni; Laura Giusti
Journal: Head Neck Pathol Date: 2019-05-16

Annexin A5 as a potential marker in tumors.

Review 1. The IgG and IgM isotypes of anti-annexin A5 antibodies: relevance for primary antiphospholipid syndrome.

2. Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells.

3. Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.

4. Annexin V expression on CD4⁺ T cells with regulatory function.

5. Proteomic Investigation of Malignant Major Salivary Gland Tumors.

Review 6. Annexin Animal Models-From Fundamental Principles to Translational Research.

7. Annexin A5 suppression promotes the progression of cervical cancer.

8. Differential effects of MTSS1 on invasion and proliferation in subtypes of non-small cell lung cancer cells.

9. Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) mice.

10. Annexin A5 promotes invasion and chemoresistance to temozolomide in glioblastoma multiforme cells.