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Literature DB >> 24118405

Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption.

Lauren C Milner¹, Renee L Shirley, Laura B Kozell, Nicole A Walter, Lauren C Kruse, Noboru H Komiyama, Seth G N Grant, Kari J Buck.

Abstract

Association studies implicate multiple PDZ domain protein (MPDZ/MUPP1) sequence and/or expression in risk for alcoholism in humans and ethanol withdrawal (EW) in mice, but confirmation has been hindered by the dearth of targeted genetic models. We report the creation of transgenic (MPDZ-TG) and knockout heterozygote (Mpdz(+/-) ) mice, with increased (2.9-fold) and decreased (53%) target expression, respectively. Both models differ in EW compared with wild-type littermates (P ≤ 0.03), providing compelling evidence for an inverse relationship between Mpdz expression and EW severity. Additionally, ethanol consumption is reduced up to 18% (P = 0.006) in Mpdz(+/-) , providing the first evidence implicating Mpdz in ethanol self-administration.

Entities: CellLine Chemical Disease Gene Species

Keywords: Consumption; MPDZ; MUPP1; ethanol; withdrawal

Mesh：

Substances：

Year: 2013 PMID： 24118405 PMCID： PMC3997615 DOI： 10.1111/adb.12087

Source DB: PubMed Journal: Addict Biol ISSN： 1355-6215 Impact factor: 4.280

19 in total

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Journal: Invert Neurosci Date: 2018-11-11