Mustafa Topuz1, Ahmet Celik, Tutku Aslantas, Ayse Kevser Demir, Suna Aydin, Suleyman Aydin. 1. From the *Department of Cardiology, Turhal State Hospital, Tokat, Turkey; †Department of Cardiology, Mersin University Medical Faculty, Mersin, Turkey; ‡Departments of Microbiology, and §Internal Medicine, Turhal State Hospital, Tokat, Turkey; ∥Department of Cardiovascular Surgery, Elazig Education and Research Hospital, Elazig, Turkey; and ¶Department of Biochemistry, Firat University Medical Faculty, Elazig, Turkey.
Abstract
OBJECTIVE: This study investigated the role of plasma adropin levels to show endothelial dysfunction in individuals with type 2 diabetes mellitus and to compare these with flow-mediated dilatation. METHODS: A total of 92 individuals with diagnosed type 2 diabetes mellitus were included and divided into 2 groups according to their brachial flow-mediated dilatation. The endothelial dysfunction group consisted of 46 participants with flow-mediated dilatation change of less than 7%, whereas 46 participants with flow-mediated dilatation change of more than 7% were accepted as the nonendothelial dysfunction group. Venous blood samples were taken from all study participants, and plasma adropin levels were measured using an enzyme-linked immunosorbent assay kit. RESULTS: The mean flow-mediated dilatation values were 13.2% ± 4.9% in the nonendothelial dysfunction group, and 3.5% ± 3.4% in the endothelial dysfunction group. Mean hemoglobin A1c levels were significantly higher in the endothelial dysfunction group than in the nonendothelial dysfunction group (8.7% ± 1.9% vs 7.9% ± 1.6%, respectively; P < 0.038). Mean plasma adropin levels were 3.04 ± 0.79 ng/mL in the endothelial dysfunction group and 4.67 ± 1.43 ng/mL in the nonendothelial dysfunction group; P < 0.001. Plasma adropin levels showed no correlation with body mass index (r = -0.072, P = 0.497) but were positively correlated with flow-mediated dilatation values (r = 0.537, P < 0.001). In the linear regression analysis, adropin and hemoglobin A1c were independent risk factors for endothelial dysfunction in individuals with type 2 diabetes mellitus. CONCLUSION: Adropin is a new marker for use in demonstrating endothelial dysfunction.
OBJECTIVE: This study investigated the role of plasma adropin levels to show endothelial dysfunction in individuals with type 2 diabetes mellitus and to compare these with flow-mediated dilatation. METHODS: A total of 92 individuals with diagnosed type 2 diabetes mellitus were included and divided into 2 groups according to their brachial flow-mediated dilatation. The endothelial dysfunction group consisted of 46 participants with flow-mediated dilatation change of less than 7%, whereas 46 participants with flow-mediated dilatation change of more than 7% were accepted as the nonendothelial dysfunction group. Venous blood samples were taken from all study participants, and plasma adropin levels were measured using an enzyme-linked immunosorbent assay kit. RESULTS: The mean flow-mediated dilatation values were 13.2% ± 4.9% in the nonendothelial dysfunction group, and 3.5% ± 3.4% in the endothelial dysfunction group. Mean hemoglobin A1c levels were significantly higher in the endothelial dysfunction group than in the nonendothelial dysfunction group (8.7% ± 1.9% vs 7.9% ± 1.6%, respectively; P < 0.038). Mean plasma adropin levels were 3.04 ± 0.79 ng/mL in the endothelial dysfunction group and 4.67 ± 1.43 ng/mL in the nonendothelial dysfunction group; P < 0.001. Plasma adropin levels showed no correlation with body mass index (r = -0.072, P = 0.497) but were positively correlated with flow-mediated dilatation values (r = 0.537, P < 0.001). In the linear regression analysis, adropin and hemoglobin A1c were independent risk factors for endothelial dysfunction in individuals with type 2 diabetes mellitus. CONCLUSION:Adropin is a new marker for use in demonstrating endothelial dysfunction.
Authors: T Kume; M Calan; O Yilmaz; G U Kocabas; P Yesil; M Temur; M Bicer; O G Calan Journal: J Endocrinol Invest Date: 2016-03-11 Impact factor: 4.256
Authors: Joseph R Stevens; Monica L Kearney; Marie-Pierre St-Onge; Kimber L Stanhope; Peter J Havel; Jill A Kanaley; John P Thyfault; Edward P Weiss; Andrew A Butler Journal: Obesity (Silver Spring) Date: 2016-08 Impact factor: 5.002