Literature DB >> 24113379

Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4.

Hui Li1, Rong Fan, Mingze Sun, Tao Jiang, Yanhua Gong.   

Abstract

Nspc1 is an identified transcription repressor. However, transiently up-regulated or down-regulated Nspc1 in P19 embryonal carcinoma cells affects expression levels of Oct4, Sox2 and Nanog in a positive correlation. Luciferase activity assays verified that Nspc1 regulates the Oct4 promoter in a dose dependent manner. ChIP assay shows that Nspc1 activates Oct4 by directly binding to the (-1021 to -784) region of Oct4 promoter. Dominant negative analysis indicated the activation is dependent on the retinoid acid response element (RARE). We demonstrated Nspc1 has a positive role in maintaining the pluripotency of P19 cells by directly regulating Oct4.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Embryonal carcinoma cells; Oct4; Polycomb group protein; Transcription regulation

Mesh：

Substances：

Year:  2013        PMID： 24113379     DOI： 10.1016/j.bbrc.2013.09.095

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Oct4-Mediated Inhibition of Lsd1 Activity Promotes the Active and Primed State of Pluripotency Enhancers.

Authors:  Lama AlAbdi; Debapriya Saha; Ming He; Mohd Saleem Dar; Sagar M Utturkar; Putu Ayu Sudyanti; Stephen McCune; Brice H Spears; James A Breedlove; Nadia A Lanman; Humaira Gowher
Journal:  Cell Rep       Date:  2020-02-04       Impact factor: 9.423

2.  lncRNAs combine and crosstalk with NSPc1 in ATRA-induced differentiation of U87 glioma cells.

Authors:  Zhikong Liang; Yuliang Wang; Hui Li; Yi Sun; Yanhua Gong
Journal:  Oncol Lett       Date:  2019-04-15       Impact factor: 2.967

3.  NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma.

Authors:  P-S Hu; Q-S Xia; F Wu; D-K Li; Y-J Qi; Y Hu; Z-Z Wei; S-S Li; N-Y Tian; Q-F Wei; L-J Shen; B Yin; T Jiang; J-G Yuan; B-Q Qiang; W Han; X-Z Peng
Journal:  Oncogene       Date:  2017-04-10       Impact factor: 9.867

4.  [PCGF1 is highly expressed in rectal adenocarcinoma and silencing PCGF1 inhibits proliferation of rectal adenocarcinoma cells in vitro].

Authors:  Y Zeng; R Fan
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2022-09-20

5.  The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

Authors:  Giorgio Oliviero; Nayla Munawar; Ariane Watson; Gundula Streubel; Gwendolyn Manning; Vivian Bardwell; Adrian P Bracken; Gerard Cagney
Journal:  Sci Rep       Date:  2015-12-21       Impact factor: 4.379

Review 6.  Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells.

Authors:  Gregory M Kelly; Mohamed I Gatie
Journal:  Stem Cells Int       Date:  2017-03-08       Impact factor: 5.443

7.  Repression of PCGF1 Decreases the Proliferation of Glioblastoma Cells in Association with Inactivation of c-Myc Signaling Pathway.

Authors:  Rui Yan; Fengmei Cui; Lijin Dong; Yong Liu; Xuewei Chen; Rong Fan
Journal:  Onco Targets Ther       Date:  2020-01-09       Impact factor: 4.147

8.  PCGF1 is a prognostic biomarker and correlates with tumor immunity in gliomas.

Authors:  Jian Xie; Lili Qiao; Guodong Deng; Ning Liang; Ligang Xing; Jiandong Zhang
Journal:  Ann Transl Med       Date:  2022-02

9.  PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment.

Authors:  Guangyu Ji; Wenjuan Zhou; Jingyi Du; Juan Zhou; Dong Wu; Man Zhao; Liping Yang; Aijun Hao
Journal:  Cell Death Dis       Date:  2021-06-19       Impact factor: 8.469
  9 in total

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