Literature DB >> 24112487

Successful surgical repair of acute type A aortic dissection without the use of blood products.

N Papalexopoulou1, R Q Attia, V N Bapat.   

Abstract

We report successful surgical treatment of type A aortic dissection in a Jehovah's Witness without the use of any blood products. An interposition graft replacement of the ascending aorta was carried out. This was under right axillo-atrial cardiopulmonary bypass with antegrade cerebral perfusion via right a subclavian and left carotid cannula for 24 minutes at 28°C. Body temperature was kept at 32°C throughout. Autologous transfusion was deployed using cell salvage and a preoperative haemodilution technique. The patient was given tranexamic acid, desmopressin, recombinant factor VIIa, folic acid and epoetin alfa. Patients who object to transfusion represent a significant challenge, especially those who are at a high risk of coagulopathy associated with inherent aortic dissection leading to perturbed haemodynamics, cardiopulmonary bypass and hypothermic circulatory arrest. Type A aortic dissection repair is possible in patients refusing the use of blood products with blood salvage techniques and synthetic products that can limit the risk of bleeding. Minimal hypothermia is vital to preserve platelet function and avoid coagulopathy. Thus, a combination of normothermic/minimal hypothermia and antegrade cerebral protection with a blood conservation strategy can be deployed for a successful surgical outcome in aortic dissection without transfusion.

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Year:  2013        PMID: 24112487      PMCID: PMC5827279          DOI: 10.1308/003588413X13629960047957

Source DB:  PubMed          Journal:  Ann R Coll Surg Engl        ISSN: 0035-8843            Impact factor:   1.891


  5 in total

1.  Bloodless surgery of acute type A aortic dissection in a Jehovah's Witness patient.

Authors:  Miralem Pasic; Wolfgang Ruisz; Andreas Koster; Roland Hetzer
Journal:  Ann Thorac Surg       Date:  2005-10       Impact factor: 4.330

2.  Aortic dissection and hypothermic arrest in a Jehovah's Witness patient: a case for recombinant factor VIIa?

Authors:  Jenifer Ballen; Michael Raabe; Brian Muirhead
Journal:  Can J Anaesth       Date:  2006-04       Impact factor: 5.063

Review 3.  Contemporary results after surgical repair of type A aortic dissection in patients aged 80 years and older: a systematic review and meta-analysis.

Authors:  Fausto Biancari; Francesco Vasques; Vincenzo Benenati; Tatu Juvonen
Journal:  Eur J Cardiothorac Surg       Date:  2011-05-10       Impact factor: 4.191

4.  How good patient blood management leads to excellent outcomes in Jehovah's witness patients undergoing cardiac surgery.

Authors:  Maximilian Y Emmert; Sacha P Salzberg; Oliver M Theusinger; Christian Felix; Andre Plass; Simon P Hoerstrup; Volkmar Falk; Juerg Gruenenfelder
Journal:  Interact Cardiovasc Thorac Surg       Date:  2010-09-09

5.  Repair of acute type A aortic dissection without the use of blood products.

Authors:  Luis D Berrizbeitia; Philip Wry; Javier Fernandez
Journal:  Heart Lung       Date:  2008 Jul-Aug       Impact factor: 2.210

  5 in total
  4 in total

1.  Randomized controlled trial of moderate hypothermia versus deep hypothermia anesthesia on brain injury during Stanford A aortic dissection surgery.

Authors:  Xufang Sun; Hua Yang; Xinyu Li; Yue Wang; Chuncheng Zhang; Zhimin Song; Zhenxiang Pan
Journal:  Heart Vessels       Date:  2017-08-23       Impact factor: 2.037

2.  Postponed surgery of an acute aortic dissection (type A) in a Jehovah's Witness with significant hemostatic disorders.

Authors:  Andrzej Biskupski; Szymon Waligórski; Krzysztof Mokrzycki; Mirosław Brykczyński
Journal:  Kardiochir Torakochirurgia Pol       Date:  2016-09-30

Review 3.  Review of abdominal solid organ transplantation in Jehovah's Witness patients.

Authors:  Rodrigo S Figueiredo; Rohan G Thakkar; Paul R Ainley; Colin H Wilson
Journal:  World J Transplant       Date:  2019-09-26

Review 4.  Outcomes of cardiac surgery in Jehovah's Witness patients: A review.

Authors:  Aimee-Louise Chambault; Louise J Brown; Sophie Mellor; Amer Harky
Journal:  Perfusion       Date:  2020-12-16       Impact factor: 1.972

  4 in total

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