| Literature DB >> 24110897 |
Angela Tooker, Teresa E Madsen, Allison Yorita, Andrea Crowell, Kedar G Shah, Sarah Felix, Helen S Mayberg, Satinderpall Pannu, Donald G Rainnie, Vanessa Tolosa.
Abstract
We present here a microfabricated, multi-functional neural interface with the ability to selectively apply electrical and chemical stimuli, while simultaneously monitoring both electrical and chemical activity in the brain. Such a comprehensive approach is required to understand and treat neuropsychiatric disorders, such as major depressive disorder (MDD), and to understand the mechanisms underlying treatments, such as pharmaceutical therapies and deep brain stimulation (DBS). The polymer-based, multi-functional neural interface is capable of electrical stimulation and recording, targeted drug delivery, and electrochemical sensing. A variety of different electrode and fluidic channel arrangements are possible with this fabrication process. Preliminary testing has shown the suitability of these neural interfaces for in vivo electrical stimulation and recording, as well as in vitro chemical sensing. Testing of the in vitro drug delivery and combined in vivo functionalities this neural interface are currently underway.Entities:
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Year: 2013 PMID： 24110897 PMCID： PMC4850550 DOI： 10.1109/EMBC.2013.6610710
Source DB: PubMed Journal: Conf Proc IEEE Eng Med Biol Soc ISSN： 1557-170X