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Literature DB >> 24108571

Real-time in situ powder X-ray diffraction monitoring of mechanochemical synthesis of pharmaceutical cocrystals.

Ivan Halasz¹, Andreas Puškarić, Simon A J Kimber, Patrick J Beldon, Ana M Belenguer, Frank Adams, Veijo Honkimäki, Robert E Dinnebier, Bhavnita Patel, William Jones, Vjekoslav Strukil, Tomislav Friščić.

Abstract

Looking in: The penetrating power of high-energy X-rays provides a means to monitor in situ and in real time the course of ball-milling reactions of organic pharmaceutical solids by detecting crystalline phases and assessing the evolution of their particle sizes. Upon switching from neat grinding to liquid-assisted grinding, cocrystal formation is enabled or tremendously accelerated, while the reaction mechanism alters its course.

Entities: Species

Keywords: X-ray diffraction; cocrystals; mechanochemistry; pharmaceutical materials; reaction monitoring

Year: 2013 PMID： 24108571 DOI： 10.1002/anie.201305928

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

13 in total

1. Force-induced tautomerization in a single molecule.

Authors: Janina N Ladenthin; Thomas Frederiksen; Mats Persson; John C Sharp; Sylwester Gawinkowski; Jacek Waluk; Takashi Kumagai
Journal: Nat Chem Date: 2016-07-04 Impact factor: 24.427

Review 2. A guide to direct mechanocatalysis.

Authors: Suhmi Hwang; Sven Grätz; Lars Borchardt
Journal: Chem Commun (Camb) Date: 2022-02-03 Impact factor: 6.222

3. Changing the game of time resolved X-ray diffraction on the mechanochemistry playground by downsizing.

Authors: Giulio I Lampronti; Adam A L Michalchuk; Paolo P Mazzeo; Ana M Belenguer; Jeremy K M Sanders; Alessia Bacchi; Franziska Emmerling
Journal: Nat Commun Date: 2021-10-21 Impact factor: 14.919

4. Challenging the Ostwald rule of stages in mechanochemical cocrystallisation.

Authors: Luzia S Germann; Mihails Arhangelskis; Martin Etter; Robert E Dinnebier; Tomislav Friščić
Journal: Chem Sci Date: 2020-08-12 Impact factor: 9.825

Review 5. Mechanochemistry: A Green Approach in the Preparation of Pharmaceutical Cocrystals.

Authors: Mizraín Solares-Briones; Guadalupe Coyote-Dotor; José C Páez-Franco; Miriam R Zermeño-Ortega; Carmen Myriam de la O Contreras; Daniel Canseco-González; Alcives Avila-Sorrosa; David Morales-Morales; Juan M Germán-Acacio
Journal: Pharmaceutics Date: 2021-05-25 Impact factor: 6.321

Real-time in situ powder X-ray diffraction monitoring of mechanochemical synthesis of pharmaceutical cocrystals.

1. Force-induced tautomerization in a single molecule.

Review 2. A guide to direct mechanocatalysis.

3. Changing the game of time resolved X-ray diffraction on the mechanochemistry playground by downsizing.

4. Challenging the Ostwald rule of stages in mechanochemical cocrystallisation.

Review 5. Mechanochemistry: A Green Approach in the Preparation of Pharmaceutical Cocrystals.

Review 6. Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs.

Review 7. Mechanochemical synthesis of thioureas, ureas and guanidines.

8. Solvation and surface effects on polymorph stabilities at the nanoscale.

9. The effect of milling frequency on a mechanochemical organic reaction monitored by in situ Raman spectroscopy.

10. Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy.