PURPOSE: Relationship between spectral domain optical coherence tomography (SD-OCT) and visual acuity (VA) in neovascular age-related macular degeneration (NVAMD). PROCEDURES: VA and SD-OCTs of 64 treatment-naive eyes with NVAMD were retrospectively collected at baseline and 1 year (n = 30). Retinal and subretinal spaces were manually analyzed. Volume and thickness measurements were correlated with VA. RESULTS: At baseline, lower VA correlated with increased volume of subretinal hyperreflective material (R = 0.4, p < 0.001) and with decreased volume of the photoreceptor layer (PRL, R = -0.4, p < 0.01). At 1 year, lower VA correlated with decreased volume of the retina (R = -0.7, p < 0.001), outer nuclear layer (R = -0.6, p < 0.05) and PRL (R = -0.7, p < 0.001). Decrease in VA after 1 year correlated with a decrease in PRL (R = 0.4, p < 0.05). CONCLUSIONS: Quantitative analysis of SD-OCT revealed correlations between VA and retinal and subretinal morphological changes in NVAMD. MESSAGE: Atrophy of the outer retina is an important correlate for lower VA in NVAMD.
PURPOSE: Relationship between spectral domain optical coherence tomography (SD-OCT) and visual acuity (VA) in neovascular age-related macular degeneration (NVAMD). PROCEDURES: VA and SD-OCTs of 64 treatment-naive eyes with NVAMD were retrospectively collected at baseline and 1 year (n = 30). Retinal and subretinal spaces were manually analyzed. Volume and thickness measurements were correlated with VA. RESULTS: At baseline, lower VA correlated with increased volume of subretinal hyperreflective material (R = 0.4, p < 0.001) and with decreased volume of the photoreceptor layer (PRL, R = -0.4, p < 0.01). At 1 year, lower VA correlated with decreased volume of the retina (R = -0.7, p < 0.001), outer nuclear layer (R = -0.6, p < 0.05) and PRL (R = -0.7, p < 0.001). Decrease in VA after 1 year correlated with a decrease in PRL (R = 0.4, p < 0.05). CONCLUSIONS: Quantitative analysis of SD-OCT revealed correlations between VA and retinal and subretinal morphological changes in NVAMD. MESSAGE: Atrophy of the outer retina is an important correlate for lower VA in NVAMD.
Authors: Alex S Willoughby; Gui-Shuang Ying; Cynthia A Toth; Maureen G Maguire; Russell E Burns; Juan E Grunwald; Ebenezer Daniel; Glenn J Jaffe Journal: Ophthalmology Date: 2015-07-02 Impact factor: 12.079
Authors: Alejandro Gonzalez-De la Rosa; Jose Navarro-Partida; Juan Carlos Altamirano-Vallejo; Ada Gabriela Hernandez-Gamez; Jesus Javier Garcia-Bañuelos; Juan Armendariz-Borunda; Arturo Santos Journal: J Ocul Pharmacol Ther Date: 2019-01-07 Impact factor: 2.671
Authors: Gabriella Moraes; Dun Jack Fu; Marc Wilson; Hagar Khalid; Siegfried K Wagner; Edward Korot; Daniel Ferraz; Livia Faes; Christopher J Kelly; Terry Spitz; Praveen J Patel; Konstantinos Balaskas; Tiarnan D L Keenan; Pearse A Keane; Reena Chopra Journal: Ophthalmology Date: 2020-09-24 Impact factor: 12.079