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Literature DB >> 24103750

Analysis of an intronic promoter within Synj2.

Abstract

Synj2 (synaptojanin 2) encodes an inositol polyphosphate phosphatase that functions in recycling neurotransmitter vesicles and is implicated in spermatogenesis. Transcription of Synj2 is thought to occur from one of two promoters based on analysis of a variable 5' untranslated region. Clustering all known mouse Synj2 transcripts led us to uncover a novel subset of transcripts that appears to derive from a region located within intron 7. We identified two alternate splice variants emanating from use of this promoter. These alternate splice variants manifest developmental stage specificity and somatic versus gametic differences in expression.

Entities: CellLine Chemical Disease Gene Species

Keywords: Inositol polyphosphate phosphatase; Mouse; Non-canonical promoter; Spermatogenesis; Synaptojanin

Mesh：

Substances：

Year: 2013 PMID： 24103750 PMCID： PMC5761313 DOI： 10.1016/j.bbrc.2013.09.115

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

31 in total

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