Literature DB >> 24101058

Substantial health and economic returns from delayed aging may warrant a new focus for medical research.

Dana P Goldman, David Cutler, John W Rowe, Pierre-Carl Michaud, Jeffrey Sullivan, Desi Peneva, S Jay Olshansky.   

Abstract

Recent scientific advances suggest that slowing the aging process (senescence) is now a realistic goal. Yet most medical research remains focused on combating individual diseases. Using the Future Elderly Model--a microsimulation of the future health and spending of older Americans--we compared optimistic "disease specific" scenarios with a hypothetical "delayed aging" scenario in terms of the scenarios' impact on longevity, disability, and major entitlement program costs. Delayed aging could increase life expectancy by an additional 2.2 years, most of which would be spent in good health. The economic value of delayed aging is estimated to be $7.1 trillion over fifty years. In contrast, addressing heart disease and cancer separately would yield diminishing improvements in health and longevity by 2060--mainly due to competing risks. Delayed aging would greatly increase entitlement outlays, especially for Social Security. However, these changes could be offset by increasing the Medicare eligibility age and the normal retirement age for Social Security. Overall, greater investment in research to delay aging appears to be a highly efficient way to forestall disease, extend healthy life, and improve public health.

Entities:  

Keywords:  Financing Health Care; Health Spending; Medical Technology

Mesh:

Year:  2013        PMID: 24101058      PMCID: PMC3938188          DOI: 10.1377/hlthaff.2013.0052

Source DB:  PubMed          Journal:  Health Aff (Millwood)        ISSN: 0278-2715            Impact factor:   6.301


  30 in total

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Authors:  Maggie Vergara; Michael Smith-Wheelock; James M Harper; Robert Sigler; Richard A Miller
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2004-12       Impact factor: 6.053

2.  Consequences of health trends and medical innovation for the future elderly.

Authors:  Dana P Goldman; Baoping Shang; Jayanta Bhattacharya; Alan M Garber; Michael Hurd; Geoffrey F Joyce; Darius N Lakdawalla; Constantijn Panis; Paul G Shekelle
Journal:  Health Aff (Millwood)       Date:  2005       Impact factor: 6.301

3.  New model of health promotion and disease prevention for the 21st century.

Authors:  Robert N Butler; Richard A Miller; Daniel Perry; Bruce A Carnes; T Franklin Williams; Christine Cassel; Jacob Brody; Marie A Bernard; Linda Partridge; Thomas Kirkwood; George M Martin; S Jay Olshansky
Journal:  BMJ       Date:  2008-07-08

4.  Even as mortality fell in most US counties, female mortality nonetheless rose in 42.8 percent of counties from 1992 to 2006.

Authors:  David A Kindig; Erika R Cheng
Journal:  Health Aff (Millwood)       Date:  2013-03       Impact factor: 6.301

5.  Exceptional parental longevity associated with lower risk of Alzheimer's disease and memory decline.

Authors:  Richard B Lipton; Jamie Hirsch; Mindy J Katz; Cuiling Wang; Amy E Sanders; Joe Verghese; Nir Barzilai; Carol A Derby
Journal:  J Am Geriatr Soc       Date:  2010-05-07       Impact factor: 5.562

6.  Reducing health care costs by reducing the need and demand for medical services. The Health Project Consortium.

Authors:  J F Fries; C E Koop; C E Beadle; P P Cooper; M J England; R F Greaves; J J Sokolov; D Wright
Journal:  N Engl J Med       Date:  1993-07-29       Impact factor: 91.245

7.  Aging, natural death, and the compression of morbidity.

Authors:  J F Fries
Journal:  N Engl J Med       Date:  1980-07-17       Impact factor: 91.245

8.  Cancer statistics, 2010.

Authors:  Ahmedin Jemal; Rebecca Siegel; Jiaquan Xu; Elizabeth Ward
Journal:  CA Cancer J Clin       Date:  2010-07-07       Impact factor: 508.702

9.  Are the young becoming more disabled?

Authors:  Darius N Lakdawalla; Jayanta Bhattacharya; Dana P Goldman
Journal:  Health Aff (Millwood)       Date:  2004 Jan-Feb       Impact factor: 6.301

10.  The genetics of extreme longevity: lessons from the new England centenarian study.

Authors:  Paola Sebastiani; Thomas T Perls
Journal:  Front Genet       Date:  2012-11-30       Impact factor: 4.599

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  100 in total

1.  Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society.

Authors:  Janko Nikolich-Žugich; Dana P Goldman; Paul R Cohen; Denis Cortese; Luigi Fontana; Brian K Kennedy; M Jane Mohler; S Jay Olshansky; Thomas Perls; Daniel Perry; Arlan Richardson; Christine Ritchie; Anne M Wertheimer; Richard G A Faragher; Mindy J Fain
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2015-09-29       Impact factor: 6.053

Review 2.  Lifespan and Healthspan: Past, Present, and Promise.

Authors:  Eileen M Crimmins
Journal:  Gerontologist       Date:  2015-11-10

Review 3.  The Economic Promise of Delayed Aging.

Authors:  Dana Goldman
Journal:  Cold Spring Harb Perspect Med       Date:  2015-12-18       Impact factor: 6.915

Review 4.  Healthy aging: The ultimate preventative medicine.

Authors:  Matt Kaeberlein; Peter S Rabinovitch; George M Martin
Journal:  Science       Date:  2015-12-04       Impact factor: 47.728

Review 5.  ComBATing aging-does increased brown adipose tissue activity confer longevity?

Authors:  Justin Darcy; Yu-Hua Tseng
Journal:  Geroscience       Date:  2019-06-22       Impact factor: 7.713

6.  Selling anti-aging research: the perils of mixed messages.

Authors:  Aubrey D N J de Grey
Journal:  Rejuvenation Res       Date:  2013-12       Impact factor: 4.663

7.  Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats.

Authors:  Caitlin S Latimer; Lawrence D Brewer; James L Searcy; Kuey-Chu Chen; Jelena Popović; Susan D Kraner; Olivier Thibault; Eric M Blalock; Philip W Landfield; Nada M Porter
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-29       Impact factor: 11.205

8.  Impact of Aging on Calcium Signaling and Membrane Potential in Endothelium of Resistance Arteries: A Role for Mitochondria.

Authors:  Erik J Behringer; Steven S Segal
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2017-11-09       Impact factor: 6.053

Review 9.  How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.

Authors:  Anatoliy I Yashin; Konstantin G Arbeev; Liubov S Arbeeva; Deqing Wu; Igor Akushevich; Mikhail Kovtun; Arseniy Yashkin; Alexander Kulminski; Irina Culminskaya; Eric Stallard; Miaozhu Li; Svetlana V Ukraintseva
Journal:  Biogerontology       Date:  2015-08-18       Impact factor: 4.277

10.  Quantification of biological aging in young adults.

Authors:  Daniel W Belsky; Avshalom Caspi; Renate Houts; Harvey J Cohen; David L Corcoran; Andrea Danese; HonaLee Harrington; Salomon Israel; Morgan E Levine; Jonathan D Schaefer; Karen Sugden; Ben Williams; Anatoli I Yashin; Richie Poulton; Terrie E Moffitt
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-06       Impact factor: 11.205

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