| Literature DB >> 24099995 |
B Vishnu Nayak1, S Ciftci-Yabanoglu, Surender Singh Jadav, Monika Jagrat, Barij N Sinha, G Ucar, Venkatesan Jayaprakash.
Abstract
Ethyl and phenyl carbamate derivatives of pyrazoline (3a-3h) were synthesized and tested for their MAO inhibitory activity. All the compounds were found to be selective towards MAO-A. Phenyl carbamates (3e-3h) were better than ethyl carbamates (3a-3d) and displayed the best selectivity index. Compound 3f (KiMAO-A; 4.96 ± 0.21 nM) was found to be equally potent as that of standard drug, Moclobemide (KiMAO-A; 5.01 ± 0.13 nM) but with best selectivity index (8.86 × 10(-5)). Molecular docking studies with R &S conformer of 3f revealed S-enantiomer is better than R-enantiomer as reported earlier by other groups. It is proposed that VdW's radii of the substitution (bulkiness) in ring B determine the potency of phenyl carbamates.Entities:
Keywords: Carbamates; Human monoamine oxidase; Inhibitors; MAO; Molecular docking; Pyrazolines; SAR; back-bone; bb; hMAO; human MAO; monoamine oxidase; rMAO; rat MAO; sc; side-chain; structure–activity-relationship
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Year: 2013 PMID： 24099995 DOI： 10.1016/j.ejmech.2013.09.010
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514