Literature DB >> 24099646

Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells.

Christian Celia1, Elena Trapasso, Marcello Locatelli, Michele Navarra, Cinzia Anna Ventura, Joy Wolfram, Maria Carafa, Valeria Maria Morittu, Domenico Britti, Luisa Di Marzio, Donatella Paolino.   

Abstract

Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications.
Copyright © 2013. Published by Elsevier B.V.

Entities:  

Keywords:  Bergamot essential oil (BEO); Cancer; Citrus extracts; Liposomes; Natural products; SH-SY5Y human neuroblastoma cells

Mesh：

Substances：

Year:  2013        PMID： 24099646     DOI： 10.1016/j.colsurfb.2013.09.017

Source DB:  PubMed          Journal:  Colloids Surf B Biointerfaces        ISSN： 0927-7765            Impact factor:   5.268


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