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Literature DB >> 24097858

Test-firing ammunition for spliceosome inhibition in cancer.

Abstract

E7107 is a derivative of the pladienolide family of natural product spliceosome inhibitors, which targets the U2 small nuclear ribonucleoprotein (snRNP) subunit SF3b. The results of a first-in-human trial with E7107 have been reported, representing an important translational step toward the goal of modulating RNA splicing for cancer therapy. Clin Cancer Res; 19(22); 6064-6. ©2013 AACR.

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Year: 2013 PMID： 24097858 PMCID： PMC3839097 DOI： 10.1158/1078-0432.CCR-13-2461

Source DB: PubMed Journal: Clin Cancer Res ISSN： 1078-0432 Impact factor: 12.531

12 in total

1. Molecular architecture of the multiprotein splicing factor SF3b.

Authors: Monika M Golas; Bjoern Sander; Cindy L Will; Reinhard Lührmann; Holger Stark
Journal: Science Date: 2003-05-09 Impact factor: 47.728

2. Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product.

Authors: Makoto Hasegawa; Tatsuhiro Miura; Kouji Kuzuya; Ayu Inoue; Se Won Ki; Sueharu Horinouchi; Tetsuo Yoshida; Tatsuki Kunoh; Koichi Koseki; Koshiki Mino; Ryuzo Sasaki; Minoru Yoshida; Tamio Mizukami
Journal: ACS Chem Biol Date: 2011-01-13 Impact factor: 5.100

3. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

Authors: Daisuke Kaida; Hajime Motoyoshi; Etsu Tashiro; Takayuki Nojima; Masatoshi Hagiwara; Ken Ishigami; Hidenori Watanabe; Takeshi Kitahara; Tatsuhiko Yoshida; Hidenori Nakajima; Tokio Tani; Sueharu Horinouchi; Minoru Yoshida
Journal: Nat Chem Biol Date: 2007-07-22 Impact factor: 15.040

Review 4. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.

Authors: Charles J David; James L Manley
Journal: Genes Dev Date: 2010-11-01 Impact factor: 11.361

5. The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.

Authors: Eric G Folco; Kaitlyn E Coil; Robin Reed
Journal: Genes Dev Date: 2011-03-01 Impact factor: 11.361

Review 6. Alternative splicing: a pivotal step between eukaryotic transcription and translation.

Authors: Alberto R Kornblihtt; Ignacio E Schor; Mariano Alló; Gwendal Dujardin; Ezequiel Petrillo; Manuel J Muñoz
Journal: Nat Rev Mol Cell Biol Date: 2013-02-06 Impact factor: 94.444

7. Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

Authors: Liying Fan; Chandraiah Lagisetti; Carol C Edwards; Thomas R Webb; Philip M Potter
Journal: ACS Chem Biol Date: 2011-03-07 Impact factor: 5.100

Review 8. Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms.

Authors: Mario Cazzola; Marianna Rossi; Luca Malcovati
Journal: Blood Date: 2012-11-16 Impact factor: 22.113

Review 9. Splicing in disease: disruption of the splicing code and the decoding machinery.

Authors: Guey-Shin Wang; Thomas A Cooper
Journal: Nat Rev Genet Date: 2007-08-29 Impact factor: 53.242

Review 10. mRNA splicing variants: exploiting modularity to outwit cancer therapy.

Authors: Scott M Dehm
Journal: Cancer Res Date: 2013-08-22 Impact factor: 12.701

12 in total

Review 1. Allosteric alterations in the androgen receptor and activity in prostate cancer.

Authors: Takuma Uo; Stephen R Plymate; Cynthia C Sprenger
Journal: Endocr Relat Cancer Date: 2017-09 Impact factor: 5.678

2. Expression levels of SF3B3 correlate with prognosis and endocrine resistance in estrogen receptor-positive breast cancer.

Authors: Yesim Gökmen-Polar; Yaseswini Neelamraju; Chirayu P Goswami; Xiaoping Gu; Gouthami Nallamothu; Sarath Chandra Janga; Sunil Badve
Journal: Mod Pathol Date: 2014-11-28 Impact factor: 7.842

3. Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC).

Authors: Weijin Xu; Huixing Huang; Long Yu; Lihuan Cao
Journal: Med Oncol Date: 2015-03-03 Impact factor: 3.064

4. Color-Coded Super-Resolution Small-Molecule Imaging.

Authors: Paolo Beuzer; James J La Clair; Hu Cang
Journal: Chembiochem Date: 2016-04-26 Impact factor: 3.164

Review 5. Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy.

Authors: Maayan Salton; Tom Misteli
Journal: Trends Mol Med Date: 2015-12-14 Impact factor: 11.951

6. Total Synthesis of the Spliceosome Modulator Pladienolide B via Asymmetric Alcohol-Mediated syn- and anti-Diastereoselective Carbonyl Crotylation.

Authors: Minjin Yoo; Michael J Krische
Journal: Angew Chem Int Ed Engl Date: 2021-05-11 Impact factor: 16.823

7. Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia.

Authors: Michael J Smout; Javier Sotillo; Thewarach Laha; Atiroch Papatpremsiri; Gabriel Rinaldi; Rafael N Pimenta; Lai Yue Chan; Michael S Johnson; Lynne Turnbull; Cynthia B Whitchurch; Paul R Giacomin; Corey S Moran; Jonathan Golledge; Norelle Daly; Banchob Sripa; Jason P Mulvenna; Paul J Brindley; Alex Loukas
Journal: PLoS Pathog Date: 2015-10-20 Impact factor: 6.823

8. Prognostic value of SRSF2 mutations in patients with de novo myelodysplastic syndromes: A meta-analysis.

Authors: Xue Zheng; Zhi Zhan; Duolan Naren; Jing Li; Tianyou Yan; Yuping Gong
Journal: PLoS One Date: 2017-09-27 Impact factor: 3.240

9. Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment.

Authors: Maxim Mogilevsky; Odelia Shimshon; Saran Kumar; Adi Mogilevsky; Eli Keshet; Eylon Yavin; Florian Heyd; Rotem Karni
Journal: Nucleic Acids Res Date: 2018-11-30 Impact factor: 16.971

10. Identification of small molecule inhibitors of pre-mRNA splicing.

Authors: Andrea Pawellek; Stuart McElroy; Timur Samatov; Lee Mitchell; Andrew Woodland; Ursula Ryder; David Gray; Reinhard Lührmann; Angus I Lamond
Journal: J Biol Chem Date: 2014-10-03 Impact factor: 5.157